Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow GAD1 rightarrow Polyclonal GAD1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • JAK2 (jak2b) Antibody
 • Helicobacter pylori, OMP Antibody
 • C3 - C3b - C3c Antibody
 • Histone H3 Antibody
 • IL-1beta (IL1B2) Recombinant Protein
 • Rat IgG2b Isotype Control Isotype Control
 • SERPINA1 Antibody
 • Total Adiponectin (ADPN) ELISA Kit
 • SIRT6 Antibody
 • microtubule-associated protein 1 light chain 3 beta (MAP1LC3... ELISA Kit
 • polo-like kinase 4 Antibody
 • Glia Maturation Factor-gamma (GMF-gamma) Protein
 • Complement C5 (C5) Recombinant Protein
 • SORBS1-ponsin Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-GAD1 antibody :: Rabbit anti-Human, Rat Glutamate decarboxylase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1492729
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutamate decarboxylase 1 (GAD1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Glutamate decarboxylase 1 polyclonal Antibody(GAD1)

 Product Synonym Names    67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform; GAD1; GAD; GAD67
 Product Gene Name   

anti-GAD1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    603513
 3D Structure    ModBase 3D Structure for Q99259
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
Section Bar
 Purity/Purification    Antigen Affinity Purified
Section Bar
 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Glutamate decarboxylase 1 protein (1-200aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-7512 / sc-7513 / sc-5602
Section Bar
 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-GAD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-GAD1 antibody

   Catalyzes the production of GABA.
 Applications Tested/Suitable for anti-GAD1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-GAD1 antibody    Recommended dilution: WB:1:500-2000
IHC:1:20-1:200
Section Bar
 Western Blot (WB) of anti-GAD1 antibody    All lanes: Glutamate decarboxylase 1 antibody at 10ug/ml+rat brain tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 67,26,48 kDa
Observed band size: 67 kDa

anti-GAD1 antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-GAD1 antibody    Immunohistochemistry of paraffin-embedded human breast cancer using MBS1492729 at dilution 1:100
anti-GAD1 antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for GAD1. It may not necessarily be applicable to this product.
 NCBI GI #    58331246
 NCBI GeneID    2571
 NCBI Accession #    NP_000808.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000817.2 [Other Products]
Section Bar
 UniProt Primary Accession #    Q99259 [Other Products]
 UniProt Secondary Accession #    Q49AK1; Q53TQ7; Q9BU91; Q9UHH4 [Other Products]
 UniProt Related Accession #    Q99259 [Other Products]
 Molecular Weight    47,440 Da
Table BarTOPTable Bar
 NCBI Official Full Name    glutamate decarboxylase 1 isoform GAD67
 NCBI Official Synonym Full Names    glutamate decarboxylase 1
 NCBI Official Symbol    GAD1 [Similar Products]
 NCBI Official Synonym Symbols   
GAD; SCP; CPSQ1
[Similar Products]
 NCBI Protein Information    glutamate decarboxylase 1
 UniProt Protein Name    Glutamate decarboxylase 1
 UniProt Synonym Protein Names   
67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform
 Protein Family    Glutamate decarboxylase
 UniProt Gene Name    GAD1 [Similar Products]
 UniProt Synonym Gene Names    GAD; GAD67; GAD-67 [Similar Products]
 UniProt Entry Name    DCE1_HUMAN
Section Bar
 NCBI Summary for GAD1    This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for GAD1    GAD67: Catalyzes the production of GABA. Homodimer. Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. Belongs to the group II decarboxylase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Other Amino Acids Metabolism - taurine and hypotaurine; Carbohydrate Metabolism - butanoate; Mitochondrial; Amino Acid Metabolism - alanine, aspartate and glutamate; Lyase; EC 4.1.1.15; Other Amino Acids Metabolism - beta-alanine

Chromosomal Location of Human Ortholog: 2q31

Cellular Component: intracellular; plasma membrane; presynaptic active zone; vesicle membrane

Molecular Function: glutamate binding; glutamate decarboxylase activity; protein binding; protein heterodimerization activity; protein N-terminus binding; pyridoxal phosphate binding

Biological Process: gamma-aminobutyric acid biosynthetic process; glutamate catabolic process; glutamate decarboxylation to succinate; neurotransmitter biosynthetic process; neurotransmitter secretion; protein-pyridoxal-5-phosphate linkage; response to drug; synaptic transmission

Disease: Cerebral Palsy, Spastic Quadriplegic, 1
Table BarTOPTable Bar
 Research Articles on GAD1    1. The GAD65-independent mechanism for targeting of GAD67 to synaptic vesicles in neurons is not functional in islet beta-cells.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-GAD1 antibodyPathways associated with anti-GAD1 antibody
 Reference Product  PubMed Publications
 RELN antibody  >10 publications with GAD1 and RELN
 SLC32A1 antibody  >2 publications with GAD1 and SLC32A1
 GLUL antibody  >2 publications with GAD1 and GLUL
 GLS antibody  >1 publications with GAD1 and GLS
 ABAT antibody  >1 publications with GAD1 and ABAT
 Products by Pathway  Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA Synthesis Pathway antibodies  GABA Synthesis Pathway Diagram
 GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies  GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram
Diseases associated with anti-GAD1 antibodyOrgans/Tissues associated with anti-GAD1 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >65 publications with GAD1 and Mental Disorders
 Schizophrenia Antibodies  >50 publications with GAD1 and Schizophrenia
 Nervous System Diseases Antibodies  >30 publications with GAD1 and Nervous System Diseases
 Brain Diseases Antibodies  >24 publications with GAD1 and Brain Diseases
 Disease Models, Animal Antibodies  >18 publications with GAD1 and Disease Models, Animal
 Anxiety Disorders Antibodies  >9 publications with GAD1 and Anxiety Disorders
 Seizures Antibodies  >9 publications with GAD1 and Seizures
 Depressive Disorder Antibodies  >8 publications with GAD1 and Depressive Disorder
 Autistic Disorder Antibodies  >6 publications with GAD1 and Autistic Disorder
 Cognition Disorders Antibodies  >5 publications with GAD1 and Cognition Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >117 publications with GAD1 and Brain
 Eye Antibodies  >3 publications with GAD1 and Eye
 Embryonic Tissue Antibodies  >2 publications with GAD1 and Embryonic Tissue
 Muscle Antibodies  >2 publications with GAD1 and Muscle
 Kidney Antibodies  >2 publications with GAD1 and Kidney
 Bone Antibodies  >1 publications with GAD1 and Bone
 Liver Antibodies  >1 publications with GAD1 and Liver
 Thymus Antibodies  >1 publications with GAD1 and Thymus
 Uncharacterized Tissue Antibodies  >1 publications with GAD1 and Uncharacterized Tissue
 Intestine Antibodies  >1 publications with GAD1 and Intestine
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions