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anti-GPX1 antibody :: Goat Glutathione Peroxidase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421332
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glutathione Peroxidase 1 (GPX1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-Glutathione Peroxidase 1 (isoform1) Antibody

 Product Synonym Names    glutathione peroxidase 1; HGNC: 4553; GPX1; GSHPX1; MGC14399; MGC88245; glutathione peroxidase 1 antibody; HGNC: 4553 antibody; GPX1 antibody; GSHPX1 antibody; MGC14399 antibody; MGC88245 antibody; Glutathione Peroxidase 1; Glutathione Peroxidase 1 (isoform1)
 Product Gene Name   

anti-GPX1 antibody

[Similar Products]
 Antibody/Peptide Pairs    Glutathione Peroxidase 1 peptide (MBS425574) is used for blocking the activity of Glutathione Peroxidase 1 antibody (MBS421332)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    REALPAPSDD ATA
 OMIM    138320
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human, Pig; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-REALPAPSDDATA, from the internal region of the protein sequence according to NP_000572.2.
 Epitope    Internal region
 Note    This antibody is expected to recognise isoform 1 (NP_000572.2) only.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GPX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GPX1 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-GPX1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Cerebral Cortex shows staining of microglia. Recommended concentration, 3-5ug/ml. Frozen sections of Porcin Kidney shows staining of cytoplasm in PCT epithelial cells. Recommended concentration, 20ug/ml.
Western Blot: Approx 22kDa band observed in Human Liver and Kidney lysates (calculated MW of 22.1kDa according to NP_000572.2). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-GPX1 antibody    (1ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-GPX1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-GPX1 antibody    (3.8ug/ml) staining of paraffin embedded Human Cerebral Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-GPX1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-GPX1 antibody    (20ug/ml) staining of PFA-perfused cryosection of Porcin Kidney. Microwave antigen retrieval with citrate buffer pH 3, CY3-staining. Data obtained from Dr. Hrvoje Brzica, University of Zagreb, Croatia
anti-GPX1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for GPX1. It may not necessarily be applicable to this product.
 NCBI GI #    41406084
 NCBI GeneID    2876
 NCBI Accession #    NP_000572.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000581.2 [Other Products]
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 UniProt Secondary Accession #    Q7Z5H1; Q9BW12; E9PAS1 [Other Products]
 UniProt Related Accession #    P07203 [Other Products]
 Molecular Weight    10,289 Da
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 NCBI Official Full Name    glutathione peroxidase 1 isoform 1
 NCBI Official Synonym Full Names    glutathione peroxidase 1
 NCBI Official Symbol    GPX1 [Similar Products]
 NCBI Official Synonym Symbols   
GPXD; GSHPX1
[Similar Products]
 NCBI Protein Information    glutathione peroxidase 1
 UniProt Protein Name    Glutathione peroxidase 1
 UniProt Synonym Protein Names   
Cellular glutathione peroxidase
 Protein Family    Glutathione peroxidase
 UniProt Gene Name    GPX1 [Similar Products]
 UniProt Synonym Gene Names    GPx-1; GSHPx-1 [Similar Products]
 UniProt Entry Name    GPX1_HUMAN
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 NCBI Summary for GPX1    This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide, and is one of the most important antioxidant enzymes in humans. This protein is one of only a few proteins known in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. In addition, this protein is characterized in a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine (ALA) repeats in this sequence. The allele with five ALA repeats is significantly associated with breast cancer risk. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GPX1    GPX1: Protects the hemoglobin in erythrocytes from oxidative breakdown. Homotetramer. Interacts with MIEN1. Belongs to the glutathione peroxidase family.

Protein type: EC 1.11.1.9; Lipid Metabolism - arachidonic acid; Other Amino Acids Metabolism - glutathione; Oxidoreductase

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion

Molecular Function: glutathione peroxidase activity; SH3 domain binding

Biological Process: angiogenesis involved in wound healing; blood vessel endothelial cell migration; cell redox homeostasis; endothelial cell development; fat cell differentiation; glutathione metabolic process; heart contraction; hydrogen peroxide catabolic process; induction of apoptosis by oxidative stress; interaction with symbiont; lipoxygenase pathway; myoblast proliferation; negative regulation of caspase activity; negative regulation of inflammatory response to antigenic stimulus; positive regulation of protein kinase B signaling cascade; protein amino acid oxidation; purine nucleotide catabolic process; regulation of gene expression, epigenetic; regulation of mammary gland epithelial cell proliferation; regulation of neuron apoptosis; response to gamma radiation; response to hydrogen peroxide; response to hydroperoxide; response to reactive oxygen species; response to selenium ion; response to symbiotic bacterium; response to xenobiotic stimulus; sensory perception of sound; skeletal muscle fiber development; skeletal muscle regeneration; thermoregulation; triacylglycerol metabolic process; UV protection; vasodilation

Disease: Glutathione Peroxidase Deficiency
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 Research Articles on GPX1    1. MIF -173CC and GPX1 594TT and high-fat diet are the risk factors for ulcerative colitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GPX1 antibodyPathways associated with anti-GPX1 antibody
 Reference Product  PubMed Publications
 SOD1 antibody  >212 publications with GPX1 and SOD1
 SOD2 antibody  >160 publications with GPX1 and SOD2
 GSTP1 antibody  >37 publications with GPX1 and GSTP1
 GSTM1 antibody  >32 publications with GPX1 and GSTM1
 GSTT1 antibody  >25 publications with GPX1 and GSTT1
 TP53 antibody  >11 publications with GPX1 and TP53
 GSS antibody  >8 publications with GPX1 and GSS
 GSTO1 antibody  >5 publications with GPX1 and GSTO1
 GSTA4 antibody  >4 publications with GPX1 and GSTA4
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
Diseases associated with anti-GPX1 antibodyOrgans/Tissues associated with anti-GPX1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >122 publications with GPX1 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >103 publications with GPX1 and Nervous System Diseases
 Inflammation Antibodies  >102 publications with GPX1 and Inflammation
 Liver Diseases Antibodies  >71 publications with GPX1 and Liver Diseases
 Heart Diseases Antibodies  >54 publications with GPX1 and Heart Diseases
 Necrosis Antibodies  >54 publications with GPX1 and Necrosis
 Breast Neoplasms Antibodies  >33 publications with GPX1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >33 publications with GPX1 and Lung Neoplasms
 Obesity Antibodies  >27 publications with GPX1 and Obesity
 Hyperglycemia Antibodies  >27 publications with GPX1 and Hyperglycemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >327 publications with GPX1 and Blood
 Liver Antibodies  >252 publications with GPX1 and Liver
 Muscle Antibodies  >121 publications with GPX1 and Muscle
 Brain Antibodies  >106 publications with GPX1 and Brain
 Heart Antibodies  >96 publications with GPX1 and Heart
 Lung Antibodies  >89 publications with GPX1 and Lung
 Kidney Antibodies  >87 publications with GPX1 and Kidney
 Vascular Antibodies  >85 publications with GPX1 and Vascular
 Intestine Antibodies  >45 publications with GPX1 and Intestine
 Prostate Antibodies  >38 publications with GPX1 and Prostate
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