O75487
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
glypican 4
NCBI Official Synonym Full Names
glypican 4
NCBI Official Synonym Symbols
NCBI Protein Information
glypican-4; OTTHUMP00000024052; dJ900E8.1 (glypican 4); glypican proteoglycan 4
UniProt Protein Name
Glypican-4
UniProt Synonym Protein Names
K-glypican
UniProt Entry Name
GPC4_HUMAN
NCBI Summary for GPC4
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome. [provided by RefSeq]
UniProt Comments for GPC4
GPC4: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system. Belongs to the glypican family.
Protein type: Motility/polarity/chemotaxis; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: Xq26.1
Cellular Component: lysosomal lumen; extracellular space; proteinaceous extracellular matrix; Golgi lumen; integral to plasma membrane; plasma membrane; nucleus; external side of plasma membrane
Molecular Function: heparan sulfate proteoglycan binding
Biological Process: chondroitin sulfate metabolic process; cell proliferation; phototransduction, visible light; glycosaminoglycan biosynthetic process; glycosaminoglycan catabolic process; anatomical structure morphogenesis; glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis; retinoid metabolic process
Disease: Simpson-golabi-behmel Syndrome, Type 1; Wilms Tumor 1
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Products associated with anti-GPC4 antibody
Pathways associated with anti-GPC4 antibody
Diseases associated with anti-GPC4 antibody
Organs/Tissues associated with anti-GPC4 antibody
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