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anti-GRN antibody :: Goat Granulin/GRN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422188
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Granulin/GRN, Polyclonal Antibody

 Also Known As   

Goat anti-Granulin/GRN Antibody

 Product Synonym Names    Goat Anti-Progranulin aa248-259 / Granulin-3 Antibody; GRN; granulin; GEP; GP88; PCDGF; PEPI; PGRN; PC cell-derived growth factor; acrogranin; granulin-epithelin; proepithelin; progranulin; GRN antibody; granulin antibody; GEP antibody; GP88 antibody; PCDGF antibody; PEPI antibody; PGRN antibody; PC cell-derived growth factor antibody; acrogranin antibody; granulin-epithelin antibody; proepithelin antibody; progranulin antibody; Granulin; Granulin / GRN
 Product Gene Name   

anti-GRN antibody

[Similar Products]
 Antibody/Peptide Pairs    Granulin / GRN peptide (MBS428398) is used for blocking the activity of Granulin/GRN antibody (MBS422188)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QSKCLSKENA TTD
 OMIM    138945
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence QSKCLSKENATTD, from the internal region of the protein sequence according to NP_002078.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-GRN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-GRN antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-GRN antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx. 60kDa band observed in lysates of A549 and HeLa (calculated MW of 63.5kDa according to NP_002078.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-GRN antibody    (1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-GRN antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GRN. It may not necessarily be applicable to this product.
 NCBI GI #    4504151
 NCBI GeneID    2896
 NCBI Accession #    NP_002078.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002087.3 [Other Products]
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 UniProt Secondary Accession #    P23781; P23782; P23783; P23784; Q53HQ8; Q53Y88; Q540U8; Q9BWE7; Q9H8S1; Q9UCH0; D3DX55 [Other Products]
 UniProt Related Accession #    P28799 [Other Products]
 Molecular Weight    44,132 Da
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 NCBI Official Full Name    granulins
 NCBI Official Synonym Full Names    granulin
 NCBI Official Symbol    GRN [Similar Products]
 NCBI Official Synonym Symbols   
GEP; GP88; PEPI; PGRN; CLN11; PCDGF
[Similar Products]
 NCBI Protein Information    granulins
 UniProt Protein Name    Granulins
 UniProt Synonym Protein Names   
Proepithelin; PEPI
 Protein Family    Granulin
 UniProt Gene Name    GRN [Similar Products]
 UniProt Synonym Gene Names    PEPI; GP88; Glycoprotein 88 [Similar Products]
 UniProt Entry Name    GRN_HUMAN
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 NCBI Summary for GRN    Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GRN    GRN: Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Defects in GRN are the cause of ubiquitin-positive frontotemporal dementia (UP-FTD); also known as tau- negative frontotemporal dementia linked to chromosome 17. Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease. Defects in GRN are the cause of neuronal ceroid lipofuscinosis type 11 (CLN11). A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material. Belongs to the granulin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: cytosol; extracellular space; intracellular membrane-bound organelle

Molecular Function: cytokine activity; growth factor activity; protein binding

Biological Process: male mating behavior; response to estradiol stimulus; signal transduction; synaptic vesicle endocytosis

Disease: Ceroid Lipofuscinosis, Neuronal, 11; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related
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 Research Articles on GRN    1. The study demonstrates increased PGRN expression at local sites of inflammation and association between PGRN levels, disease activity, and functional impairment in patients with Rheumatoid Arthritis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Goat anti-Granulin/GRN Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS2543482  Mouse anti Human Granulin/GRN/Progranulin Monoclonal Antibody  MBS422188  Goat anti-Granulin/GRN Antibody
Products associated with anti-GRN antibodyPathways associated with anti-GRN antibody
 Reference Product  PubMed Publications
 TARDBP antibody  >27 publications with GRN and TARDBP
 SLPI antibody  >8 publications with GRN and SLPI
 SORT1 antibody  >7 publications with GRN and SORT1
 CCND1 antibody  >2 publications with GRN and CCND1
 AKT1 antibody  >1 publications with GRN and AKT1
 MMP13 antibody  >1 publications with GRN and MMP13
 CCNT1 antibody  >1 publications with GRN and CCNT1
 Products by Pathway  Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with anti-GRN antibodyOrgans/Tissues associated with anti-GRN antibody
 Disease Name  Pubmed Publications
 Dementia Antibodies  >445 publications with GRN and Dementia
 Brain Diseases Antibodies  >417 publications with GRN and Brain Diseases
 Frontotemporal Lobar Degeneration Antibodies  >363 publications with GRN and Frontotemporal Lobar Degeneration
 Frontotemporal Dementia Antibodies  >326 publications with GRN and Frontotemporal Dementia
 Inflammation Antibodies  >90 publications with GRN and Inflammation
 Necrosis Antibodies  >51 publications with GRN and Necrosis
 Nerve Degeneration Antibodies  >44 publications with GRN and Nerve Degeneration
 Memory Disorders Antibodies  >29 publications with GRN and Memory Disorders
 Cognition Disorders Antibodies  >27 publications with GRN and Cognition Disorders
 Breast Neoplasms Antibodies  >25 publications with GRN and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >322 publications with GRN and Brain
 Blood Antibodies  >197 publications with GRN and Blood
 Nerve Antibodies  >79 publications with GRN and Nerve
 Vascular Antibodies  >43 publications with GRN and Vascular
 Embryonic Tissue Antibodies  >41 publications with GRN and Embryonic Tissue
 Liver Antibodies  >40 publications with GRN and Liver
 Bone Antibodies  >36 publications with GRN and Bone
 Muscle Antibodies  >32 publications with GRN and Muscle
 Heart Antibodies  >28 publications with GRN and Heart
 Lung Antibodies  >22 publications with GRN and Lung
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