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anti-gro2 antibody :: Rabbit Groucho 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS616829 anti-gro2 antibody
Unit / Price
0.05 mg  /  $350 +1 FREE 8GB USB
 
 Product Name   

Groucho 2 (gro2), Polyclonal Antibody

 Also Known As   

Groucho 2 (TLE2, ESG2, Transcription Factor)

 Product Synonym Names    Anti -Groucho 2 (TLE2, ESG2, Transcription Factor)
 Product Gene Name   

anti-gro2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 18; NC_007129.5 (20007518..20036903)
 3D Structure    ModBase 3D Structure for O13166
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rodent
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 Specificity    Recognizes human Groucho 2 / TLE2 / ESG2 transcription factor.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS pH 7.2. No preservatives added.
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 Immunogen    Synthetic peptide corresponding to aa220-235, KEPSGPYESDEDKSDY from human Groucho 2, coupled with BSA.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-gro2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-gro2 antibody

   Groucho2 (TLE2) (Transducin-Like Enhancer Protein 2, ESG2) is a member of the Groucho family of transcriptional corepressors. It inhibits the transcriptional activation mediated by b-catenin and TCF family members in Wnt signaling.
 Product Categories/Family for anti-gro2 antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-gro2 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-gro2 antibody    Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry: 1:200-1:1000
Western Blot: 1:200-1:1000
ELISA: 1:200-1:1000
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NCBI/Uniprot data below describe general gene information for gro2. It may not necessarily be applicable to this product.
 NCBI GI #    18858771
 NCBI GeneID    30206
 NCBI Accession #    NP_571087.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_131012.1 [Other Products]
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 UniProt Primary Accession #    O13166 [Other Products]
 UniProt Related Accession #    O13166; Q1LXH1 [Other Products]
 Molecular Weight    82,460 Da [Similar Products]
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 NCBI Official Full Name    protein groucho-2
 NCBI Official Synonym Full Names    groucho 2
 NCBI Official Symbol    gro2 [Similar Products]
 NCBI Official Synonym Symbols   
zfgro2; GROUCHO2
[Similar Products]
 NCBI Protein Information    protein groucho-2; groucho-related Grg2
 UniProt Protein Name    Protein groucho-2
 UniProt Synonym Protein Names   
Groucho-related Grg2
 Protein Family    Protein groucho
 UniProt Gene Name    gro2 [Similar Products]
 UniProt Synonym Gene Names    grg2; groucho2 [Similar Products]
 UniProt Entry Name    TLE2_DANRE
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 UniProt Comments for gro2    Function: Transcriptional corepressor that binds to a number of transcription factors

Subunit structure: Interacts with the WRPW motif of ripply1. Ref.2

Subcellular location: Nucleus

Probable.

Tissue specificity: Expressed ubiquitously during gastrulation. Expressed in the entire presomitic mesoderm, including the tailbud, throughout somitogenesis. Also expressed diffusely within whole somites in young stages. In older stages, expression is restricted to boundaries between somites. Also expressed in a dynamic manner within the neural plate. Ref.1

Developmental stage: Expressed both maternally and zygotically. Expression decreases from the midblastula stages onwards before increasing again at the start of gastrulation. Ref.1

Sequence similarities: Belongs to the WD repeat Groucho/TLE family.Contains 7 WD repeats.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-gro2 antibodyOrgans/Tissues associated with anti-gro2 antibody
 Products by Pathway  Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Canonical Wnt - Zebrafish Pathway antibodies  Canonical Wnt - Zebrafish Pathway Diagram
 Noncanonical Wnt Pathway antibodies  Noncanonical Wnt Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with gro2 and Kidney
 Muscle Antibodies  >1 publications with gro2 and Muscle
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