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anti-Cd74 antibody :: Rabbit anti-Rat H-2 class II histocompatibility antigen gamma chain Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1490858
Western Blot (WB)
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

H-2 class II histocompatibility antigen gamma chain (Cd74), Polyclonal Antibody

 Also Known As   

Rabbit anti-rat H-2 class II histocompatibility antigen gamma chain polyclonal Antibody, Biotin conjugated

 Product Synonym Names    Ia antigen-associated invariant chain; Ii; MHC class II-associated invariant chain; CD74; Cd74
 Product Gene Name   

anti-Cd74 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P10247
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Rat
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Biotin
 Immunogen    Recombinant rat H-2 class II histocompatibility antigen gamma chain protein
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-Cd74 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Cd74 antibody

   Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.
 Applications Tested/Suitable for anti-Cd74 antibody   

ELISA (EIA)

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 Western Blot (WB) of anti-Cd74 antibody    western blot All lanes: H-2 class II histocompatibility antigen gamma chain antibody at 2ug/ml+mouse lung tissue secondary Goat polyclonal to rabbit at 1/10000 dilution predicted band size:34kDa observed band size:34kDa
anti-Cd74 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for Cd74. It may not necessarily be applicable to this product.
 NCBI GI #    6978637
 NCBI GeneID    25599
 NCBI Accession #    NP_037201.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013069.2 [Other Products]
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 UniProt Primary Accession #    P10247 [Other Products]
 UniProt Related Accession #    P10247 [Other Products]
 Molecular Weight    24,503 Da [Similar Products]
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 NCBI Official Full Name    H-2 class II histocompatibility antigen gamma chain
 NCBI Official Synonym Full Names    CD74 molecule
 NCBI Official Symbol    Cd74 [Similar Products]
 NCBI Official Synonym Symbols   
INVG34
[Similar Products]
 NCBI Protein Information    H-2 class II histocompatibility antigen gamma chain
 UniProt Protein Name    H-2 class II histocompatibility antigen gamma chain
 UniProt Synonym Protein Names   
Ia antigen-associated invariant chain; Ii; MHC class II-associated invariant chain; CD_antigen: CD74
 Protein Family    H-2 class II histocompatibility antigen
 UniProt Gene Name    Cd74 [Similar Products]
 UniProt Synonym Gene Names    Ii [Similar Products]
 UniProt Entry Name    HG2A_RAT
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 UniProt Comments for Cd74    CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine; Endoplasmic reticulum

Cellular Component: cell surface; endoplasmic reticulum; external side of plasma membrane; Golgi apparatus; integral to membrane; late endosome; lysosome; membrane; MHC class II protein complex; multivesicular body; plasma membrane; vacuole

Molecular Function: beta-amyloid binding; cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; MHC class II protein binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase binding

Biological Process: activation of MAPK activity; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; chaperone cofactor-dependent protein folding; defense response; immunoglobulin mediated immune response; intracellular protein transport; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of mature B cell apoptosis; negative regulation of peptide secretion; negative regulation of T cell differentiation; negative thymic T cell selection; positive regulation of B cell proliferation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of dendritic cell antigen processing and presentation; positive regulation of fibroblast proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; positive regulation of T-helper 2 type immune response; positive thymic T cell selection; prostaglandin biosynthetic process; protein complex assembly; signal transduction
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 Research Articles on Cd74    1. Methylglyoxal induced gene expression of CD74 in the in the diabetic retina.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Cd74 antibodyPathways associated with anti-Cd74 antibody
 Reference Product  PubMed Publications
 RT1-Da antibody  >3 publications with Cd74 and RT1-Da
 RT1-Ba antibody  >1 publications with Cd74 and RT1-Ba
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 MHC Class II Antigen Presentation Pathway antibodies  MHC Class II Antigen Presentation Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
Diseases associated with anti-Cd74 antibodyOrgans/Tissues associated with anti-Cd74 antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >117 publications with Cd74 and Immune System Diseases
 Inflammation Antibodies  >99 publications with Cd74 and Inflammation
 Carcinoma Antibodies  >71 publications with Cd74 and Carcinoma
 Disease Models, Animal Antibodies  >37 publications with Cd74 and Disease Models, Animal
 Lung Neoplasms Antibodies  >32 publications with Cd74 and Lung Neoplasms
 Brain Diseases Antibodies  >22 publications with Cd74 and Brain Diseases
 Necrosis Antibodies  >19 publications with Cd74 and Necrosis
 Carcinoma, Non-Small-Cell Lung Antibodies  >18 publications with Cd74 and Carcinoma, Non-Small-Cell Lung
 Kidney Diseases Antibodies  >16 publications with Cd74 and Kidney Diseases
 Chromosome Aberrations Antibodies  >13 publications with Cd74 and Chromosome Aberrations
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >60 publications with Cd74 and Lung
 Brain Antibodies  >48 publications with Cd74 and Brain
 Kidney Antibodies  >24 publications with Cd74 and Kidney
 Liver Antibodies  >19 publications with Cd74 and Liver
 Stomach Antibodies  >18 publications with Cd74 and Stomach
 Heart Antibodies  >17 publications with Cd74 and Heart
 Muscle Antibodies  >16 publications with Cd74 and Muscle
 Spleen Antibodies  >16 publications with Cd74 and Spleen
 Artery Antibodies  >14 publications with Cd74 and Artery
 Colon Antibodies  >8 publications with Cd74 and Colon
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