NP_001207420.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
cadherin-13 isoform 5
NCBI Official Synonym Full Names
cadherin 13
NCBI Official Synonym Symbols
NCBI Protein Information
cadherin-13
UniProt Protein Name
Cadherin-13
UniProt Synonym Protein Names
Heart cadherin; H-cadherin; P105; Truncated cadherin; T-cad; T-cadherin
UniProt Synonym Gene Names
UniProt Entry Name
CAD13_HUMAN
NCBI Summary for CDH13
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]
UniProt Comments for CDH13
CDH13: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor; Cell adhesion
Chromosomal Location of Human Ortholog: 16q23.3
Cellular Component: extracellular space; neuron projection; focal adhesion; cytoplasm; plasma membrane; caveola; external side of plasma membrane
Molecular Function: adiponectin binding; protein homodimerization activity; cadherin binding; low-density lipoprotein binding; calcium ion binding
Biological Process: lamellipodium biogenesis; intercellular junction assembly and maintenance; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; Rac protein signal transduction; positive regulation of calcium-mediated signaling; negative regulation of cell adhesion; keratinocyte proliferation; Rho protein signal transduction; regulation of epidermal growth factor receptor signaling pathway; low density lipoprotein mediated signaling; negative regulation of cell proliferation; localization within membrane; regulation of endocytosis; calcium-dependent cell-cell adhesion; endothelial cell migration; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; sprouting angiogenesis; positive regulation of cell-matrix adhesion; homophilic cell adhesion; positive regulation of cell migration
Product References and Citations for anti-CDH13 antibody
Qian,Z.R., Mod. Pathol. 20 (12), 1269-1277 (2007) Tsou,J.A., Mol. Cancer 6, 70 (2007)
Research Articles on CDH13
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Products associated with anti-CDH13 antibody
Diseases associated with anti-CDH13 antibody
Organs/Tissues associated with anti-CDH13 antibody
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