NP_005334
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,870 Da
NCBI Official Full Name
GTPase HRas isoform 1
NCBI Official Synonym Full Names
Harvey rat sarcoma viral oncogene homolog
NCBI Official Synonym Symbols
CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1 [Similar Products]
NCBI Protein Information
GTPase HRas
UniProt Protein Name
GTPase HRas
UniProt Synonym Protein Names
H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras
UniProt Synonym Gene Names
UniProt Entry Name
RASH_HUMAN
NCBI Summary for H-Ras
This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for H-Ras
HRas: a small GTPase protein of the Ras family. Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Mutations are implicated in a variety of human tumors.
Protein type: G protein, monomeric; G protein; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: cytoplasm; cytosol; Golgi apparatus; Golgi membrane; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function: GTP binding; GTPase activity; protein binding; protein C-terminus binding
Biological Process: activation of MAPKK activity; axon guidance; blood coagulation; cell cycle arrest; cell proliferation; cell surface receptor linked signal transduction; chemotaxis; endocytosis; ephrin receptor signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; leukocyte migration; MAPKKK cascade; mitotic cell cycle checkpoint; negative regulation of cell proliferation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; organ morphogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of GTPase activity; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of transcription from RNA polymerase II promoter; protein heterooligomerization; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; signal transduction; small GTPase mediated signal transduction; social behavior; stimulatory C-type lectin receptor signaling pathway; synaptic transmission; vascular endothelial growth factor receptor signaling pathway
Disease: Bladder Cancer; Costello Syndrome; Melanocytic Nevus Syndrome, Congenital; Nevus, Epidermal; Schimmelpenning-feuerstein-mims Syndrome; Thyroid Carcinoma, Follicular
Research Articles on H-Ras
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Products associated with anti-H-Ras antibody
Pathways associated with anti-H-Ras antibody
Diseases associated with anti-H-Ras antibody
Organs/Tissues associated with anti-H-Ras antibody
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