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anti-H3F3B antibody :: Rabbit H3F3B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2527155
Testing Data
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

H3F3B, Polyclonal Antibody

★Popular Item★
 Also Known As   

H3F3B Antibody

 Product Synonym Names    H3.3B; H3F3A
 Product Gene Name   

anti-H3F3B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601058
 3D Structure    ModBase 3D Structure for BC001124
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
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 Immunogen    Fusion protein of H3F3B
 Calculated Molecular Weight    15kd
 Observed Molecular Weight    17kd
 Buffer    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-H3F3B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-H3F3B antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-H3F3B antibody    WB: 1:200-1:1000
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 Testing Data of anti-H3F3B antibody    HeLa cells were subjected to SDS-PAGE followed by Western Blot with H3F3B antibody at dilution of 1:300
anti-H3F3B antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for H3F3B. It may not necessarily be applicable to this product.
 NCBI GI #    4885385
 NCBI GeneID    3021
 NCBI Accession #    NP_005315.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005324.4 [Other Products]
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 UniProt Primary Accession #    BC001124 [Other Products]
 UniProt Secondary Accession #    P06351; P33155; Q5VV55; Q5VV56; Q66I33; Q9V3W4 [Other Products]
 UniProt Related Accession #    P84243 [Other Products]
 Molecular Weight    15,328 Da
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 NCBI Official Full Name    histone H3.3
 NCBI Official Synonym Full Names    H3 histone, family 3B (H3.3B)
 NCBI Official Symbol    H3F3B [Similar Products]
 NCBI Official Synonym Symbols   
H3.3B
[Similar Products]
 NCBI Protein Information    histone H3.3
 UniProt Protein Name    Histone H3.3
 UniProt Gene Name    H3F3A [Similar Products]
 UniProt Synonym Gene Names    H3.3A; H3F3 [Similar Products]
 UniProt Entry Name    H33_HUMAN
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 NCBI Summary for H3F3B    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a member of the histone H3 family. Pseudogenes of this gene have been identified on the X chromosome, and on chromosomes 5, 13 and 17. [provided by RefSeq, Jan 2015]
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 UniProt Comments for H3F3B    H3F3A: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Interacts with HIRA, a chaperone required for its incorporation into nucleosomes. Belongs to the histone H3 family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1q42.12

Cellular Component: nucleoplasm; nuclear chromosome; protein complex; extracellular region; nucleosome; nucleus

Molecular Function: protein binding; nucleosomal DNA binding; protein heterodimerization activity

Biological Process: chromatin silencing at rDNA; nucleosome assembly; DNA replication-independent nucleosome assembly; negative regulation of gene expression, epigenetic; gene expression; blood coagulation; regulation of gene expression, epigenetic; positive regulation of cell growth; DNA methylation on cytosine
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 Research Articles on H3F3B    1. A remarkable picture of tumor type specificity for histone H3.3 driver alterations emerges, indicating that histone H3.3 residues, mutations and genes have distinct functions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-H3F3B antibodyDiseases associated with anti-H3F3B antibody
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Condensation Of Prophase Chromosomes Pathway antibodies  Condensation Of Prophase Chromosomes Pathway Diagram
 DNA Methylation Pathway antibodies  DNA Methylation Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Prostatic Diseases Antibodies  >2 publications with H3F3B and Prostatic Diseases
 Ovarian Diseases Antibodies  >1 publications with H3F3B and Ovarian Diseases
 Adenocarcinoma Antibodies  >1 publications with H3F3B and Adenocarcinoma
 Infertility, Male Antibodies  >1 publications with H3F3B and Infertility, Male
 Giant Cell Tumor of Bone Antibodies  >1 publications with H3F3B and Giant Cell Tumor of Bone
Organs/Tissues associated with anti-H3F3B antibody
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >3 publications with H3F3B and Testis
 Prostate Antibodies  >2 publications with H3F3B and Prostate
 Blood Antibodies  >2 publications with H3F3B and Blood
 Brain Antibodies  >2 publications with H3F3B and Brain
 Adipose Tissue Antibodies  >1 publications with H3F3B and Adipose Tissue
 Vascular Antibodies  >1 publications with H3F3B and Vascular
 Ascites Antibodies  >1 publications with H3F3B and Ascites
 Bone Antibodies  >1 publications with H3F3B and Bone
 Embryonic Tissue Antibodies  >1 publications with H3F3B and Embryonic Tissue
 Lung Antibodies  >1 publications with H3F3B and Lung
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