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anti-HP antibody :: Sheep HAPTOGLOBIN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS223298
Testing Data #1
Unit / Price
1 mL  /  $400 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HAPTOGLOBIN (HP), Polyclonal Antibody

 Also Known As   

SHEEP ANTI HUMAN HAPTOGLOBIN:HRP

 Product Gene Name   

anti-HP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    140100
 3D Structure    ModBase 3D Structure for P00738
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Sheep
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 Form/Format    HRP
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.01% Thiomersal
 Immunogen    Native, from serum
Buffer Solution
 Antiserum Preparation    Antisera to Haptoglobin were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-HP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HP antibody

   Sheep anti Human Haptoglobin antibody detects haptoglobin, also known as Hp, an acute phase plasma glycoprotein synthesized by the liver in response to infection or inflammation. Haptoglobin binds haemoglobin released by erythrocytes with high affinity, and functions to block the oxidative activity of haemoglobin and prevent renal damage. The haptoglobin-haemoglobin complex is rapidly removed from the circulation by monocytes and macrophages, via the receptor CD163. The haptoglobin genotype has been demonstrated to be an independent risk factor for cardiovascular disease in multiple epidemiological studies.
 Applications Tested/Suitable for anti-HP antibody   

ELISA (EIA)

 Application Notes for anti-HP antibody    ELISA: Minimum Dilution: 1/100; Maximum Dilution: 1/1000
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 Testing Data #1 of anti-HP antibody    Human Haptoglobin detected with Sheep anti Human Haptoglobin: HRP (MBS223298)
anti-HP antibody Testing Data #1 image
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NCBI/Uniprot data below describe general gene information for HP. It may not necessarily be applicable to this product.
 NCBI GI #    186910296
 NCBI GeneID    3240
 NCBI Accession #    NP_001119574.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001126102.1 [Other Products]
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 UniProt Primary Accession #    P00738 [Other Products]
 UniProt Secondary Accession #    P00737; Q0VAC4; Q0VAC5; Q2PP15; Q3B7J0; Q6LBY9; Q9UC67; B0AZL5 [Other Products]
 UniProt Related Accession #    P00738 [Other Products]
 Molecular Weight    38,452 Da [Similar Products]
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 NCBI Official Full Name    haptoglobin isoform 2 preproprotein
 NCBI Official Synonym Full Names    haptoglobin
 NCBI Official Symbol    HP [Similar Products]
 NCBI Official Synonym Symbols   
BP; HPA1S; HP2ALPHA2
[Similar Products]
 NCBI Protein Information    haptoglobin; binding peptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; zonulin
 UniProt Protein Name    Haptoglobin
 UniProt Synonym Protein Names   
ZonulinCleaved into the following 2 chains:Haptoglobin alpha chain; Haptoglobin beta chain
 Protein Family    Haptoglobin
 UniProt Gene Name    HP [Similar Products]
 UniProt Entry Name    HPT_HUMAN
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 NCBI Summary for HP    This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
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 UniProt Comments for HP    HP: Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes. Defects in HP are the cause of anhaptoglobinemia (AHP). AHP is a condition characterized by the absence of the serum glycoprotein haptoglobin. Serum levels of haptoglobin vary among normal persons: levels are low in the neonatal period and in the elderly, differ by population, and can be influenced by environmental factors, such as infection. Secondary hypohaptoglobinemia can occur as a consequence of hemolysis, during which haptoglobin binds to free hemoglobin. Belongs to the peptidase S1 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: extracellular space; extracellular region

Molecular Function: antioxidant activity; protein binding; hemoglobin binding; catalytic activity

Biological Process: receptor-mediated endocytosis; response to hydrogen peroxide; metabolic process; immune system process; defense response to bacterium; negative regulation of oxidoreductase activity; acute-phase response; defense response

Disease: Anhaptoglobinemia
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 Research Articles on HP    1. Serum zonulin is increased in polycystic ovary syndrome and correlates with insulin resistance and severity of anovulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HP antibodyPathways associated with anti-HP antibody
 Reference Product  PubMed Publications
 CD163 antibody  >60 publications with HP and CD163
 APOE antibody  >30 publications with HP and APOE
 IL6 antibody  >28 publications with HP and IL6
 HBA1 antibody  >26 publications with HP and HBA1
 APOA1 antibody  >13 publications with HP and APOA1
 HBB antibody  >4 publications with HP and HBB
 MIS12 antibody  >2 publications with HP and MIS12
 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram
 Amb2 Integrin Signaling Pathway antibodies  Amb2 Integrin Signaling Pathway Diagram
Diseases associated with anti-HP antibodyOrgans/Tissues associated with anti-HP antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1611 publications with HP and Cardiovascular Diseases
 Inflammation Antibodies  >1117 publications with HP and Inflammation
 Hypersensitivity Antibodies  >648 publications with HP and Hypersensitivity
 Liver Diseases Antibodies  >593 publications with HP and Liver Diseases
 Disease Models, Animal Antibodies  >530 publications with HP and Disease Models, Animal
 Hypertension Antibodies  >482 publications with HP and Hypertension
 Kidney Diseases Antibodies  >470 publications with HP and Kidney Diseases
 Autoimmune Diseases Antibodies  >466 publications with HP and Autoimmune Diseases
 Necrosis Antibodies  >458 publications with HP and Necrosis
 Fibrosis Antibodies  >441 publications with HP and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5506 publications with HP and Blood
 Brain Antibodies  >1267 publications with HP and Brain
 Liver Antibodies  >1212 publications with HP and Liver
 Lung Antibodies  >1135 publications with HP and Lung
 Muscle Antibodies  >727 publications with HP and Muscle
 Kidney Antibodies  >680 publications with HP and Kidney
 Connective Tissue Antibodies  >326 publications with HP and Connective Tissue
 Bone Marrow Antibodies  >220 publications with HP and Bone Marrow
 Adipose Tissue Antibodies  >174 publications with HP and Adipose Tissue
 Ovary Antibodies  >146 publications with HP and Ovary
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