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anti-HAX1 antibody :: Rabbit HAX1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS769997 (SPECIAL PROMOTIONAL PRICING for a limited time)
Unit / Price
0.1 mg  /  $180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HAX1, Polyclonal Antibody

★Popular Item★
 Also Known As   

HAX1 Rabbit Polyclonal

 Product Synonym Names    FLJ17042, FLJ18492, FLJ93803, HAX 1, HAX1, HCLS1 associated protein X 1, HCLSBP1, HS1 associating protein X 1, HS1 binding protein 1, HS1BP1, HSP1BP 1, SCN3
 Product Gene Name   

anti-HAX1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605998
 3D Structure    ModBase 3D Structure for O00165
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Human, Mouse; other species are not tested. Please decide the specificity by homology
 Purity/Purification    >=95% as determined by SDS-PAGE
Immunogen Affinity Purified
 Form/Format    Liquid
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 Immunogen    HCLS1 associated protein X-1
 Buffer    PBS with 0.02% sodium azide and 50% glycerol pH 7.3
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 Preparation and Storage    -20 degree C for 24 months (Avoid repeated freeze/thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HAX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HAX1 antibody

   HAX1, also named as HS1BP1, is a 32 kDa protein that is ubiquitously expressed. Hax1 has beendemonstrated to be a negative regulator of apoptosis in many immune cell types. Furthermore, Hax1has been shown to have additional roles in regulating cell motility and adhesion, and isoverexpressed in many types of cancer. Kristina and Cavnar demonstrate in their paper validation oftwo research antibodies including Proteintech’s anti-Hax1 (11266-1-AP). They have evidence thatthe rabbit anti-Hax1 (11266-1-AP, Proteintech Group Inc.) results in a more robust and consistentdetection of Hax1.
 Applications Tested/Suitable for anti-HAX1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

 Application Notes for anti-HAX1 antibody    WB : 1:200-1:1000
IP : 1:200-1:1000
IHC : 1:20-1:200
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 Immunohistochemistry of anti-HAX1 antibody    Immunohistochemistry of paraffin-embedded human lymphoma using MBS769997 (HAX1 antibody) at dilution of 1:50
anti-HAX1 antibody Immunohistochemistry (IHC) image
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 IP of anti-HAX1 antibody    IP Result of anti-HAX1 (IP: MBS769997, 3ug; Detection: MBS769997 (1:300) with mouse brain tissue lysate 6000ug.
anti-HAX1 antibody IP image
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 SDS-PAGE of anti-HAX1 antibody    HeLa cells were subjected to SDS PAGE followed by western blot with MBS769997 (HAX1 Antibody) at dilution of 1:300
anti-HAX1 antibody SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for HAX1. It may not necessarily be applicable to this product.
 NCBI GI #    66363694
 NCBI GeneID    10456
 NCBI Accession #    NP_001018238.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001018837.1 [Other Products]
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 UniProt Primary Accession #    O00165 [Other Products]
 UniProt Secondary Accession #    Q5VYD5; Q5VYD7; Q96AU4; Q9BS80; A8W4W9; A8W4X0; B4DUJ7 [Other Products]
 UniProt Related Accession #    O00165 [Other Products]
 Molecular Weight    32 kDa
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 NCBI Official Full Name    HCLS1-associated protein X-1 isoform b
 NCBI Official Synonym Full Names    HCLS1 associated protein X-1
 NCBI Official Symbol    HAX1 [Similar Products]
 NCBI Official Synonym Symbols   
SCN3; HS1BP1; HCLSBP1
[Similar Products]
 NCBI Protein Information    HCLS1-associated protein X-1
 UniProt Protein Name    HCLS1-associated protein X-1
 UniProt Synonym Protein Names   
HS1-associating protein X-1; HAX-1; HS1-binding protein 1; HSP1BP-1
 Protein Family    HCLS1-associated protein
 UniProt Gene Name    HAX1 [Similar Products]
 UniProt Synonym Gene Names    HS1BP1; HAX-1; HSP1BP-1 [Similar Products]
 UniProt Entry Name    HAX1_HUMAN
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 NCBI Summary for HAX1    The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HAX1    HAX1: Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools. Defects in HAX1 are the cause of neutropenia severe congenital autosomal recessive type 3 (SCN3); also known as Kostmann disease. A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. Some patients affected by severe congenital neutropenia type 3 have neurological manifestations such as psychomotor retardation and seizures. The clinical phenotype due to HAX1 deficiency appears to depend on the localization of the mutations and their influence on the transcript variants. Mutations affecting exclusively isoform 1 are associated with isolated congenital neutropenia, whereas mutations affecting both isoform 1 and isoform 5 are associated with additional neurologic symptoms. Belongs to the HAX1 family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Endoplasmic reticulum; Vesicle; Mitochondrial

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: actin cytoskeleton; cytoplasmic membrane-bound vesicle; endoplasmic reticulum; lamellipodium; mitochondrial intermembrane space; mitochondrial outer membrane; mitochondrion; nuclear envelope; nuclear membrane; sarcoplasmic reticulum; transcription factor complex

Molecular Function: interleukin-1 binding; protein binding; protein N-terminus binding

Biological Process: mitochondrion organization and biogenesis; negative regulation of apoptosis; positive regulation of granulocyte differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of transcription from RNA polymerase II promoter; regulation of actin filament polymerization; regulation of apoptosis

Disease: Neutropenia, Severe Congenital, 3, Autosomal Recessive
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 Research Articles on HAX1    1. HAX-1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HAX1 antibodyDiseases associated with anti-HAX1 antibody
 Reference Product  PubMed Publications
 HTRA2 antibody  >5 publications with HAX1 and HTRA2
 CTTN antibody  >3 publications with HAX1 and CTTN
 GRB7 antibody  >2 publications with HAX1 and GRB7
 PKD2 antibody  >2 publications with HAX1 and PKD2
 BCL2 antibody  >1 publications with HAX1 and BCL2
 ABCB11 antibody  >1 publications with HAX1 and ABCB11
 Disease Name  Pubmed Publications
 Neutropenia, Severe Congenital, Autosomal Recessive 3 Antibodies  >23 publications with HAX1 and Neutropenia, Severe Congenital, Autosomal Recessive 3
 Cell Transformation, Neoplastic Antibodies  >10 publications with HAX1 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >8 publications with HAX1 and Neoplasm Metastasis
 Heart Diseases Antibodies  >5 publications with HAX1 and Heart Diseases
 Disease Models, Animal Antibodies  >3 publications with HAX1 and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >3 publications with HAX1 and Neurobehavioral Manifestations
 Fever Antibodies  >2 publications with HAX1 and Fever
 Carcinoma, Hepatocellular Antibodies  >2 publications with HAX1 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >2 publications with HAX1 and Liver Diseases
 Skin Neoplasms Antibodies  >2 publications with HAX1 and Skin Neoplasms
Organs/Tissues associated with anti-HAX1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >46 publications with HAX1 and Blood
 Bone Antibodies  >25 publications with HAX1 and Bone
 Bone Marrow Antibodies  >25 publications with HAX1 and Bone Marrow
 Muscle Antibodies  >11 publications with HAX1 and Muscle
 Heart Antibodies  >11 publications with HAX1 and Heart
 Skin Antibodies  >10 publications with HAX1 and Skin
 Liver Antibodies  >7 publications with HAX1 and Liver
 Brain Antibodies  >7 publications with HAX1 and Brain
 Lymph Node Antibodies  >5 publications with HAX1 and Lymph Node
 Lymph Antibodies  >5 publications with HAX1 and Lymph
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