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anti-HBG1 antibody :: Rabbit anti-Human HBG1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS642015
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HBG1, Polyclonal Antibody

★Popular Item★
 Also Known As   

HBG1, ID (HBG1, Hemoglobin subunit gamma-1, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain)

 Product Synonym Names    Anti -HBG1, ID (HBG1, Hemoglobin subunit gamma-1, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain)
 Product Gene Name   

anti-HBG1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (5269502..5271087, complement). Location: 11p15.5
 OMIM    142200
 3D Structure    ModBase 3D Structure for P69891
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human HBG1
 Purity/Purification    Purified by Protein A and peptide affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
 Concentration    0.5 mg/ml (lot specific)
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 Immunogen    KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 56-85 in the central region of human HBG1.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-HBG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HBG1 antibody

   The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
 Product Categories/Family for anti-HBG1 antibody    Antibodies; Abs to Hemoglobin
 Applications Tested/Suitable for anti-HBG1 antibody   

Western Blot (WB), ELISA

 Application Notes for anti-HBG1 antibody    Suitable for use in Western Blot and ELISA. Other applications not tested.
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.
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 Western Blot of anti-HBG1 antibody    Western Blot analysis of HBG 1 (arrow) on 293 ceillysates (2ug/lane) using MBS642015
Lane 1: nontransfected
Lane 2: transiently transfected with the HBG 1 gene.
anti-HBG1 antibody Western Blot (WB) image
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 Western Blot of anti-HBG1 antibody    Western Blot analysis in K562 cell line Iysates (35ug/lane) using MBS642015.
This demonstrates the HBG 1 antibody detected the HBG 1 protein (arrow).
anti-HBG1 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for HBG1. It may not necessarily be applicable to this product.
 NCBI GI #    28302131
 NCBI GeneID    3047
 NCBI Accession #    NP_000550.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000559.2 [Other Products]
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 UniProt Primary Accession #    P69891 [Other Products]
 UniProt Secondary Accession #    P02096; P62027; Q549G1; Q8TDA1; Q96FH7 [Other Products]
 UniProt Related Accession #    P69891 [Other Products]
 Molecular Weight    16,140 Da [Similar Products]
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 NCBI Official Full Name    hemoglobin subunit gamma-1
 NCBI Official Synonym Full Names    hemoglobin, gamma A
 NCBI Official Symbol    HBG1 [Similar Products]
 NCBI Official Synonym Symbols   
HBGA; HBGR; HSGGL1; PRO2979
[Similar Products]
 NCBI Protein Information    hemoglobin subunit gamma-1; hb F Agamma; gamma globin; A-gamma globin; gamma-1-globin; gamma A hemoglobin; hemoglobin gamma-1 chain; hemoglobin gamma-a chain; hemoglobin, gamma, regulator of
 UniProt Protein Name    Hemoglobin subunit gamma-1
 UniProt Synonym Protein Names   
Gamma-1-globin; Hb F Agamma; Hemoglobin gamma-1 chain; Hemoglobin gamma-A chain
 Protein Family    Hemoglobin
 UniProt Gene Name    HBG1 [Similar Products]
 UniProt Entry Name    HBG1_HUMAN
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 NCBI Summary for HBG1    The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HBG1    HBG1: Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. Belongs to the globin family.

Protein type: Carrier

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: hemoglobin complex; cytosol

Molecular Function: iron ion binding; heme binding; oxygen binding; oxygen transporter activity

Biological Process: oxygen transport; blood coagulation

Disease: Fetal Hemoglobin Quantitative Trait Locus 1
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 Research Articles on HBG1    1. the stimulation of GPCRs supports the postulated connection between cAMP/PKA and NO/cGMP pathways in activation of gamma-globin expression, via JUN and p38 MAPK signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HBG1 antibodyDiseases associated with anti-HBG1 antibody
 Reference Product  PubMed Publications
 HBG2 antibody  >17 publications with HBG1 and HBG2
 HBA2 antibody  >3 publications with HBG1 and HBA2
 HBA1 antibody  >2 publications with HBG1 and HBA1
 HBE1 antibody  >2 publications with HBG1 and HBE1
 BCL11A antibody  >2 publications with HBG1 and BCL11A
 KLF1 antibody  >1 publications with HBG1 and KLF1
 HBS1L antibody  >1 publications with HBG1 and HBS1L
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1 publications with HBG1 and Nervous System Diseases
 Neoplasms Antibodies  >1 publications with HBG1 and Neoplasms
Organs/Tissues associated with anti-HBG1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with HBG1 and Blood
 Vascular Antibodies  >1 publications with HBG1 and Vascular
 Bone Antibodies  >1 publications with HBG1 and Bone
 Ovary Antibodies  >1 publications with HBG1 and Ovary
 Embryonic Tissue Antibodies  >1 publications with HBG1 and Embryonic Tissue
 Heart Antibodies  >1 publications with HBG1 and Heart
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