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anti-HCFC1 antibody :: Rabbit HCFC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS128001
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HCFC1, Polyclonal Antibody

 Also Known As   

HCFC1 Polyclonal Antibody

 Product Synonym Names    CFF; HCF1; HFC1; MRX3; VCAF; HCF-1
 Product Gene Name   

anti-HCFC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 309541
 3D Structure    ModBase 3D Structure for P51610
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human HCFC1
 Calculated Molecular Weight    209kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-HCFC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HCFC1 antibody

   This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
 Product Categories/Family for anti-HCFC1 antibody    Polyclonal
 Applications Tested/Suitable for anti-HCFC1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-HCFC1 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-HCFC1 antibody    Western blot analysis of extracts of various cell lines, using HCFC1 antibody at 1:500 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 90s.
anti-HCFC1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for HCFC1. It may not necessarily be applicable to this product.
 NCBI GI #    160332311
 NCBI GeneID    3054
 NCBI Accession #    P51610.2 [Other Products]
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 UniProt Primary Accession #    P51610 [Other Products]
 UniProt Secondary Accession #    Q6P4G5 [Other Products]
 UniProt Related Accession #    P51610; AAB27583 [Other Products]
 Molecular Weight    2035
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 NCBI Official Full Name    Host cell factor 1
 NCBI Official Synonym Full Names    host cell factor C1
 NCBI Official Symbol    HCFC1 [Similar Products]
 NCBI Official Synonym Symbols   
CFF; HCF; HCF1; HFC1; MRX3; VCAF; HCF-1; PPP1R89
[Similar Products]
 NCBI Protein Information    host cell factor 1; VP16-accessory protein; protein phosphatase 1, regulatory subunit 89
 UniProt Protein Name    Host cell factor 1
 UniProt Synonym Protein Names   
C1 factor; CFF; VCAF; VP16 accessory proteinCleaved into the following 12 chains:HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6
 Protein Family    Host cell factor
 UniProt Gene Name    HCFC1 [Similar Products]
 UniProt Synonym Gene Names    HCF1; HFC1; HCF; HCF-1 [Similar Products]
 UniProt Entry Name    HCFC1_HUMAN
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 NCBI Summary for HCFC1    This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HCFC1    HCFC1: Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: nucleoplasm; membrane; cell soma; mitochondrion; cytoplasm; nucleus; histone acetyltransferase complex

Molecular Function: identical protein binding; protein binding; transcription coactivator activity; chromatin binding; histone acetyltransferase activity (H4-K16 specific); transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; establishment and/or maintenance of chromatin architecture; protein stabilization; regulation of transcription, DNA-dependent; organelle organization and biogenesis; reactivation of latent virus; positive regulation of cell cycle; regulation of protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cell cycle

Disease: Methylmalonic Acidemia And Homocysteinemia, Cblx Type
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 Research Articles on HCFC1    1. study reports the tetratricopeptide-repeat domain of O-GlcNAc transferase binds the carboxyl-terminal portion of an HCF-1 proteolytic repeat such that the cleavage region lies in the glycosyltransferase active site above uridine diphosphate-GlcNAc; protein glycosylation and HCF-1 cleavage occur in the same active site
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HCFC1 antibodyPathways associated with anti-HCFC1 antibody
 Reference Product  PubMed Publications
 POU2F1 antibody  >388 publications with HCFC1 and POU2F1
 CREB3 antibody  >10 publications with HCFC1 and CREB3
 BAP1 antibody  >8 publications with HCFC1 and BAP1
 OGT antibody  >7 publications with HCFC1 and OGT
 WDR5 antibody  >4 publications with HCFC1 and WDR5
 RBBP5 antibody  >2 publications with HCFC1 and RBBP5
 ASH2L antibody  >2 publications with HCFC1 and ASH2L
 SETD1A antibody  >2 publications with HCFC1 and SETD1A
 MYST1 antibody  >1 publications with HCFC1 and MYST1
 CREBZF antibody  >1 publications with HCFC1 and CREBZF
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Mitochondrial Gene Expression Pathway antibodies  Mitochondrial Gene Expression Pathway Diagram
 Mitochondrial Biogenesis Pathway antibodies  Mitochondrial Biogenesis Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
 Transcriptional Activation Of Mitochondrial Biogenesis Pathway antibodies  Transcriptional Activation Of Mitochondrial Biogenesis Pathway Diagram
Diseases associated with anti-HCFC1 antibodyOrgans/Tissues associated with anti-HCFC1 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >11 publications with HCFC1 and Necrosis
 Nervous System Diseases Antibodies  >9 publications with HCFC1 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >7 publications with HCFC1 and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >7 publications with HCFC1 and Adenocarcinoma
 Inflammation Antibodies  >6 publications with HCFC1 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >5 publications with HCFC1 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >4 publications with HCFC1 and Breast Neoplasms
 Kidney Diseases Antibodies  >4 publications with HCFC1 and Kidney Diseases
 Lung Diseases Antibodies  >3 publications with HCFC1 and Lung Diseases
 Liver Diseases Antibodies  >3 publications with HCFC1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >101 publications with HCFC1 and Blood
 Liver Antibodies  >25 publications with HCFC1 and Liver
 Brain Antibodies  >22 publications with HCFC1 and Brain
 Kidney Antibodies  >15 publications with HCFC1 and Kidney
 Embryonic Tissue Antibodies  >11 publications with HCFC1 and Embryonic Tissue
 Lung Antibodies  >11 publications with HCFC1 and Lung
 Muscle Antibodies  >9 publications with HCFC1 and Muscle
 Vascular Antibodies  >8 publications with HCFC1 and Vascular
 Thymus Antibodies  >8 publications with HCFC1 and Thymus
 Bone Antibodies  >7 publications with HCFC1 and Bone
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