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anti-HCK antibody :: Rabbit anti-Human HCK Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9211135
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HCK, Polyclonal Antibody

 Also Known As   

HCK Antibody (N-term)

 Product Synonym Names    Tyrosine-protein kinase HCK; Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck; HCK
 Product Gene Name   

anti-HCK antibody

[Similar Products]
 Antibody/Peptide Pairs    HCK peptide (MBS9227188) is used for blocking the activity of HCK antibody (MBS9211135)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    1-30
 OMIM    142370
 3D Structure    ModBase 3D Structure for P08631
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This HCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HCK.
 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.45 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-HCK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HCK antibody

   HCK is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.
 Product Categories/Family for anti-HCK antibody    Immunology; Signal Transduction
 Applications Tested/Suitable for anti-HCK antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-HCK antibody    WB~~1:1000
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 Western Blot (WB) of anti-HCK antibody    HCK Antibody (E8) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the HCK antibody detected the HCK protein (arrow).
anti-HCK antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for HCK. It may not necessarily be applicable to this product.
 NCBI GI #    287326139
 NCBI GeneID    3055
 NCBI Accession #    NP_001165600.1 [Other Products]
 NCBI Related Accession #    NP_001165601.1; NP_001165602.1; NP_001165604.1; NP_002101.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001172129.1 [Other Products]
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 UniProt Primary Accession #    P08631 [Other Products]
 UniProt Secondary Accession #    Q29RX1; Q2VPE2; Q504R5; Q5T7K1; Q5T7K2; Q96CC0; Q9H5Y5; Q9NUA4; A8K1I1; B4DQB6; E1P5M2 [Other Products]
 UniProt Related Accession #    P08631 [Other Products]
 Molecular Weight    59600
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 NCBI Official Full Name    tyrosine-protein kinase HCK isoform b
 NCBI Official Synonym Full Names    HCK proto-oncogene, Src family tyrosine kinase
 NCBI Official Symbol    HCK [Similar Products]
 NCBI Official Synonym Symbols   
JTK9; p59Hck; p61Hck
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase HCK
 UniProt Protein Name    Tyrosine-protein kinase HCK
 UniProt Synonym Protein Names   
Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    HCK [Similar Products]
 UniProt Entry Name    HCK_HUMAN
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 NCBI Summary for HCK    The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]
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 UniProt Comments for HCK    Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.

Protein type: Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; Oncoprotein; EC 2.7.10.2; TK group; Src family

Chromosomal Location of Human Ortholog: 20q11-q12

Cellular Component: Golgi apparatus; transport vesicle; extrinsic to internal side of plasma membrane; focal adhesion; cell projection; lysosome; actin filament; caveola; cytosol; nucleus

Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: respiratory burst after phagocytosis; peptidyl-tyrosine phosphorylation; viral reproduction; protein amino acid autophosphorylation; regulation of phagocytosis; protein amino acid phosphorylation; regulation of cell shape; leukocyte migration during immune response; regulation of transcription factor activity; leukocyte degranulation; positive regulation of cell proliferation; lipopolysaccharide-mediated signaling pathway; mesoderm development; cell differentiation; innate immune response-activating signal transduction; inflammatory response; cell adhesion; integrin-mediated signaling pathway; cytokine and chemokine mediated signaling pathway; regulation of defense response to virus by virus; positive regulation of actin filament polymerization; regulation of inflammatory response; innate immune response; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
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Product References and Citations for anti-HCK antibody

   Komuro, I., et al., J. Exp. Med. 198(3):443-453 (2003).
Lake, J.A., et al., J. Clin. Virol. 26(2):143-152 (2003).
Stanglmaier, M., et al., Leukemia 17(2):283-289 (2003).
Lerner, E.C., et al., Nat. Struct. Biol. 9(5):365-369 (2002).
Chang, A.H., et al., Eur. J. Immunol. 31(8):2382-2387 (2001).
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 Research Articles on HCK    1. Interaction with the Src homology (SH3-SH2) region of the Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-HCK antibodyOrgans/Tissues associated with anti-HCK antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >38 publications with HCK and Inflammation
 Necrosis Antibodies  >29 publications with HCK and Necrosis
 Carcinoma Antibodies  >24 publications with HCK and Carcinoma
 Death Antibodies  >13 publications with HCK and Death
 Lung Diseases Antibodies  >11 publications with HCK and Lung Diseases
 Kidney Diseases Antibodies  >9 publications with HCK and Kidney Diseases
 Vascular Diseases Antibodies  >8 publications with HCK and Vascular Diseases
 Neoplasms, Experimental Antibodies  >7 publications with HCK and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >7 publications with HCK and Cardiovascular Diseases
 Brain Diseases Antibodies  >7 publications with HCK and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >208 publications with HCK and Blood
 Lung Antibodies  >22 publications with HCK and Lung
 Kidney Antibodies  >16 publications with HCK and Kidney
 Spleen Antibodies  >15 publications with HCK and Spleen
 Eye Antibodies  >15 publications with HCK and Eye
 Brain Antibodies  >10 publications with HCK and Brain
 Prostate Antibodies  >9 publications with HCK and Prostate
 Testis Antibodies  >6 publications with HCK and Testis
 Ovary Antibodies  >5 publications with HCK and Ovary
 Embryonic Tissue Antibodies  >4 publications with HCK and Embryonic Tissue
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