NP_005468.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
NCBI Official Synonym Full Names
hyperpolarization activated cyclic nucleotide gated potassium channel 4
NCBI Official Synonym Symbols
NCBI Protein Information
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
UniProt Protein Name
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
UniProt Entry Name
HCN4_HUMAN
NCBI Summary for HCN4
This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]
UniProt Comments for HCN4
HCN4: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli. Defects in HCN4 are a cause of sick sinus syndrome type 2 (SSS2); also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors, in which case it is considered to be a congenital disorder. Defects in HCN4 are the cause of Brugada syndrome type 8 (BRGDA8). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the potassium channel HCN family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, cation
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; terminal button; intrinsic to plasma membrane
Molecular Function: identical protein binding; voltage-gated potassium channel activity; intracellular cAMP activated cation channel activity; voltage-gated sodium channel activity; cAMP binding
Biological Process: synaptic transmission; regulation of membrane potential; muscle contraction; regulation of heart rate; in utero embryonic development; blood circulation; cation transport
Disease: Sick Sinus Syndrome 2, Autosomal Dominant; Brugada Syndrome 8
Research Articles on HCN4
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Products associated with anti-HCN4 antibody
Pathways associated with anti-HCN4 antibody
Diseases associated with anti-HCN4 antibody
Organs/Tissues associated with anti-HCN4 antibody
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