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anti-HDAC1 antibody :: Rabbit anti-Human HDAC1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1495517
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HDAC1, Polyclonal Antibody

★Popular Item★
 Also Known As   

HDAC1 Antibody

 Product Synonym Names    Histone deacetylase 1 (EC:3.5.1.98); HD1; HDAC1; RPD3L1
 Product Gene Name   

anti-HDAC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601241
 3D Structure    ModBase 3D Structure for Q13547
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Histone deacetylase 1 protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6298 / sc-6299 / sc-7872
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HDAC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HDAC1 antibody

   Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.
 Applications Tested/Suitable for anti-HDAC1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

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 Immunohistochemistry (IHC) of anti-HDAC1 antibody    Immunohistochemistry of paraffin-embedded human testis using MBS1495517 at dilution 1:100
anti-HDAC1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-HDAC1 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS1495517 at dilution 1:100
anti-HDAC1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-HDAC1 antibody    Immunohistochemistry of paraffin-embedded human melanoma cancer using MBS1495517 at dilution of 1:100
anti-HDAC1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-HDAC1 antibody    Immunohistochemistry of paraffin-embedded human thyroid tissue using MBS1495517 at dilution of 1:100
anti-HDAC1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-HDAC1 antibody    Immunofluorescence staining of Hela cells with MBS1495517 at 1:133,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 degree C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
anti-HDAC1 antibody Immunofluorescence (IF) image
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 Chromatin Immunoprecipitation (ChIP) of anti-HDAC1 antibody    Chromatin Immunoprecipitation MCF7(1.1^106)were cross-linked with formaldehyde, sonicated, and immunoprecipitated with 4ug anti-HDAC1 or a control normal rabbit IgG . The resulting ChIP DNA was quantified using real-time PCR with primers against the P21 promoter.
anti-HDAC1 antibody Chromatin Immunoprecipitation (ChIP) (IP) image
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NCBI/Uniprot data below describe general gene information for HDAC1. It may not necessarily be applicable to this product.
 NCBI GI #    13128860
 NCBI GeneID    3065
 NCBI Accession #    NP_004955.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004964.2 [Other Products]
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 UniProt Primary Accession #    Q13547 [Other Products]
 UniProt Secondary Accession #    Q92534 [Other Products]
 UniProt Related Accession #    Q13547 [Other Products]
 Molecular Weight    55,103 Da
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 NCBI Official Full Name    histone deacetylase 1
 NCBI Official Synonym Full Names    histone deacetylase 1
 NCBI Official Symbol    HDAC1 [Similar Products]
 NCBI Official Synonym Symbols   
HD1; RPD3; GON-10; RPD3L1
[Similar Products]
 NCBI Protein Information    histone deacetylase 1
 UniProt Protein Name    Histone deacetylase 1
 UniProt Gene Name    HDAC1 [Similar Products]
 UniProt Synonym Gene Names    RPD3L1; HD1 [Similar Products]
 UniProt Entry Name    HDAC1_HUMAN
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 NCBI Summary for HDAC1    Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HDAC1    HDAC1: a transcriptional regulator of the histone deacetylase family, subfamily 1. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein type: EC 3.5.1.98; Nuclear receptor co-regulator; Hydrolase

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: chromatin; cytoplasm; cytosol; histone deacetylase complex; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; protein complex; Sin3 complex

Molecular Function: deacetylase activity; enzyme binding; histone deacetylase activity; histone deacetylase binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NF-kappaB binding; nucleosomal DNA binding; protein binding; protein deacetylase activity; protein N-terminus binding; transcription activator binding; transcription factor activity; transcription factor binding

Biological Process: ATP-dependent chromatin remodeling; blood coagulation; chromatin modification; chromatin remodeling; circadian regulation of gene expression; embryonic digit morphogenesis; epidermal cell differentiation; establishment and/or maintenance of chromatin architecture; gene expression; histone deacetylation; mitotic cell cycle; negative regulation of apoptosis; negative regulation of cell cycle; negative regulation of gene expression, epigenetic; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; Notch signaling pathway; odontogenesis of dentine-containing teeth; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid deacetylation; regulation of gene expression, epigenetic; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; viral reproduction
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 Research Articles on HDAC1    1. Overexpression of histone deacetylase 1 was associated with lung adenocarcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HDAC1 antibodyPathways associated with anti-HDAC1 antibody
 Reference Product  PubMed Publications
 DNMT1 antibody  >123 publications with HDAC1 and DNMT1
 SIN3A antibody  >92 publications with HDAC1 and SIN3A
 KDM1A antibody  >23 publications with HDAC1 and KDM1A
 MTA2 antibody  >18 publications with HDAC1 and MTA2
 RCOR1 antibody  >16 publications with HDAC1 and RCOR1
 RBBP4 antibody  >15 publications with HDAC1 and RBBP4
 CHD4 antibody  >14 publications with HDAC1 and CHD4
 RBBP7 antibody  >9 publications with HDAC1 and RBBP7
 CHD3 antibody  >5 publications with HDAC1 and CHD3
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-HDAC1 antibodyOrgans/Tissues associated with anti-HDAC1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >105 publications with HDAC1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >104 publications with HDAC1 and Adenocarcinoma
 Inflammation Antibodies  >81 publications with HDAC1 and Inflammation
 Nervous System Diseases Antibodies  >68 publications with HDAC1 and Nervous System Diseases
 Necrosis Antibodies  >62 publications with HDAC1 and Necrosis
 Disease Models, Animal Antibodies  >59 publications with HDAC1 and Disease Models, Animal
 Liver Diseases Antibodies  >59 publications with HDAC1 and Liver Diseases
 Lung Neoplasms Antibodies  >50 publications with HDAC1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >47 publications with HDAC1 and Carcinoma, Hepatocellular
 Neoplasm Metastasis Antibodies  >46 publications with HDAC1 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >157 publications with HDAC1 and Brain
 Blood Antibodies  >143 publications with HDAC1 and Blood
 Lung Antibodies  >125 publications with HDAC1 and Lung
 Liver Antibodies  >121 publications with HDAC1 and Liver
 Muscle Antibodies  >84 publications with HDAC1 and Muscle
 Prostate Antibodies  >75 publications with HDAC1 and Prostate
 Bone Antibodies  >63 publications with HDAC1 and Bone
 Heart Antibodies  >58 publications with HDAC1 and Heart
 Kidney Antibodies  >52 publications with HDAC1 and Kidney
 Vascular Antibodies  >49 publications with HDAC1 and Vascular
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