NP_006028.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
106,367 Da
NCBI Official Full Name
histone deacetylase 4
NCBI Official Synonym Full Names
histone deacetylase 4
NCBI Official Synonym Symbols
HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A [Similar Products]
NCBI Protein Information
histone deacetylase 4; histone deacetylase A
UniProt Protein Name
Histone deacetylase 4
UniProt Synonym Gene Names
UniProt Entry Name
HDAC4_HUMAN
NCBI Summary for HDAC4
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
UniProt Comments for HDAC4
HDAC4: a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Protein type: Nuclear receptor co-regulator; Hydrolase; EC 3.5.1.98; Deacetylase
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: nucleoplasm; transcriptional repressor complex; cytoplasm; histone deacetylase complex; actomyosin; Z disc; nucleus; cytosol; neuromuscular junction; A band
Molecular Function: potassium ion binding; transcription activator binding; zinc ion binding; histone deacetylase binding; protein deacetylase activity; protein kinase binding; transcription factor binding; NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription corepressor activity
Biological Process: cardiac muscle hypertrophy; positive regulation of transcription, DNA-dependent; response to denervation involved in regulation of muscle adaptation; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; negative regulation of cell proliferation; positive regulation of cell proliferation; negative regulation of osteoblast differentiation; negative regulation of glycolysis; inflammatory response; skeletal development; response to drug; nervous system development; regulation of skeletal muscle fiber development; transcription, DNA-dependent; B cell activation; negative regulation of transcription factor activity; histone deacetylation; osteoblast development; positive regulation of protein sumoylation; chromatin remodeling; B cell differentiation; regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of transcription, DNA-dependent
Research Articles on HDAC4
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Products associated with anti-HDAC4 antibody
Pathways associated with anti-HDAC4 antibody
Diseases associated with anti-HDAC4 antibody
Organs/Tissues associated with anti-HDAC4 antibody
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