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anti-HER2 antibody :: Rabbit HER2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9407916
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HER2, Polyclonal Antibody

★Popular Item★
 Also Known As   

HER2 (Ab-1248) Antibody

 Product Synonym Names    C-erbB-2; ErbB2
 Product Gene Name   

anti-HER2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137215
 3D Structure    ModBase 3D Structure for P04626
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    The antibody detects endogenous level of total HER2 protein.
 Purity/Purification    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
 Form/Format    Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Peptide-KLH
 Immunogen Description    Peptide sequence around aa. 1246~1250 (P-E-Y-L-G) derived from Human HER2.
 Target Name    HER2
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 Preparation and Storage    Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.
 Other Notes    Small volumes of anti-HER2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HER2 antibody

   Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-a and amphiregulin.
 Product Categories/Family for anti-HER2 antibody    Total protein Ab
 Applications Tested/Suitable for anti-HER2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-HER2 antibody    Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200
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 Western Blot (WB) of anti-HER2 antibody    Western blot analysis of extracts from MCF and SKOV3 cells using HER2(Ab-1248) Antibody.
anti-HER2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HER2 antibody    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HER2(Ab-1248) Antibody (left) or the same antibody preincubated with blocking peptide(right).
anti-HER2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-HER2 antibody    Immunofluorescence staining of methanol-fixed MCF7 cells using HER2(Ab-1248) Antibody.
anti-HER2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for HER2. It may not necessarily be applicable to this product.
 NCBI GI #    54792098
 NCBI GeneID    2064
 NCBI Accession #    NP_001005862.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001005862.2 [Other Products]
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 UniProt Primary Accession #    P04626 [Other Products]
 UniProt Secondary Accession #    Q14256; Q6LDV1; Q9UMK4; B2RZG3; B4DHN3; X5D2V5 [Other Products]
 UniProt Related Accession #    P04626 [Other Products]
 Molecular Weight    97,253 Da
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 NCBI Official Full Name    receptor tyrosine-protein kinase erbB-2 isoform b
 NCBI Official Synonym Full Names    erb-b2 receptor tyrosine kinase 2
 NCBI Official Symbol    ERBB2 [Similar Products]
 NCBI Official Synonym Symbols   
NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu
[Similar Products]
 NCBI Protein Information    receptor tyrosine-protein kinase erbB-2
 UniProt Protein Name    Receptor tyrosine-protein kinase erbB-2
 UniProt Synonym Protein Names   
Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD_antigen: CD340
 UniProt Gene Name    ERBB2 [Similar Products]
 UniProt Synonym Gene Names    HER2; MLN19; NEU; NGL; MLN 19 [Similar Products]
 UniProt Entry Name    ERBB2_HUMAN
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 NCBI Summary for HER2    This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HER2    HER2: a proto-oncogenic receptor tyrosine kinase of the EGFR family. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. Not activated by EGF, TGF- alpha and amphiregulin. Amplified in breast cancer. Overexpression induces constitutive activity, and the gene is amplified or overexpressed in up to 30% of breast cancers, correlating with poor survival. The antibody Herceptin is approved for treatment of metastatic breast cancer with HER2 amplification/overexpression. Somatic mutations seen in 4% of lung cancers and also in breast, gastric, ovarian cancer and glioblastoma. One SNP shows predisposition to breast and gastric cancer. Inhibitors: Herceptin, lapatinib, PKI-166, EKB-569, CI-1033.

Protein type: Oncoprotein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Kinase, protein; TK group; EGFR family

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: perinuclear region of cytoplasm; basolateral plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; endosome membrane; cytoplasmic vesicle; nucleus; receptor complex

Molecular Function: protein dimerization activity; protein C-terminus binding; identical protein binding; protein binding; transmembrane receptor activity; ErbB-3 class receptor binding; protein heterodimerization activity; growth factor binding; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; protein phosphatase binding; ATP binding

Biological Process: myelination; axon guidance; phosphoinositide 3-kinase cascade; positive regulation of cell adhesion; peptidyl-tyrosine phosphorylation; wound healing; positive regulation of translation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; heart development; motor axon guidance; signal transduction; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase I promoter; positive regulation of MAP kinase activity; cell surface receptor linked signal transduction; oligodendrocyte differentiation; neuromuscular junction development; negative regulation of immature T cell proliferation in the thymus; epidermal growth factor receptor signaling pathway; regulation of microtubule-based process; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; transcription, DNA-dependent; regulation of angiogenesis; positive regulation of cell growth; peripheral nervous system development; cell proliferation; innate immune response; positive regulation of transcription from RNA polymerase III promoter; positive regulation of protein amino acid phosphorylation; positive regulation of epithelial cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Gastric Cancer; Lung Cancer; Glioma Susceptibility 1
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 Research Articles on HER2    1. PTPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination barcodes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HER2 antibodyPathways associated with anti-HER2 antibody
 Reference Product  PubMed Publications
 EGFR antibody  >3111 publications with HER2 and EGFR
 ERBB3 antibody  >862 publications with HER2 and ERBB3
 SRC antibody  >415 publications with HER2 and SRC
 CTNNB1 antibody  >193 publications with HER2 and CTNNB1
 GRB2 antibody  >109 publications with HER2 and GRB2
 ERBB2IP antibody  >45 publications with HER2 and ERBB2IP
 SHC1 antibody  >36 publications with HER2 and SHC1
 PTPN11 antibody  >14 publications with HER2 and PTPN11
 UBC antibody  >6 publications with HER2 and UBC
 HSP90AA1 antibody  >1 publications with HER2 and HSP90AA1
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
Diseases associated with anti-HER2 antibodyOrgans/Tissues associated with anti-HER2 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >7012 publications with HER2 and Carcinoma
 Adenocarcinoma Antibodies  >3713 publications with HER2 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >3104 publications with HER2 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >1768 publications with HER2 and Neoplasms, Experimental
 Disease Progression Antibodies  >1751 publications with HER2 and Disease Progression
 Gastrointestinal Neoplasms Antibodies  >1429 publications with HER2 and Gastrointestinal Neoplasms
 Lymphatic Metastasis Antibodies  >1410 publications with HER2 and Lymphatic Metastasis
 Carcinogenesis Antibodies  >1371 publications with HER2 and Carcinogenesis
 Lung Neoplasms Antibodies  >1263 publications with HER2 and Lung Neoplasms
 Ovarian Neoplasms Antibodies  >1091 publications with HER2 and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2309 publications with HER2 and Blood
 Lymph Node Antibodies  >2067 publications with HER2 and Lymph Node
 Lung Antibodies  >1485 publications with HER2 and Lung
 Stomach Antibodies  >862 publications with HER2 and Stomach
 Brain Antibodies  >693 publications with HER2 and Brain
 Liver Antibodies  >623 publications with HER2 and Liver
 Prostate Antibodies  >518 publications with HER2 and Prostate
 Bone Antibodies  >505 publications with HER2 and Bone
 Mammary Gland Antibodies  >479 publications with HER2 and Mammary Gland
 Heart Antibodies  >452 publications with HER2 and Heart
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