NP_001035798.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
32-34 kDa
NCBI Official Full Name
hairy/enhancer-of-split related with YRPW motif protein 1 isoform b
NCBI Official Synonym Full Names
hes related family bHLH transcription factor with YRPW motif 1
NCBI Official Synonym Symbols
CHF2; OAF1; HERP2; HESR1; HRT-1; hHRT1; BHLHb31 [Similar Products]
NCBI Protein Information
hairy/enhancer-of-split related with YRPW motif protein 1
UniProt Protein Name
Hairy/enhancer-of-split related with YRPW motif protein 1
UniProt Synonym Protein Names
Cardiovascular helix-loop-helix factor 2; CHF-2; Class B basic helix-loop-helix protein 31; bHLHb31; HES-related repressor protein 1; Hairy and enhancer of split-related protein 1; HESR-1; Hairy-related transcription factor 1; HRT-1; hHRT1
UniProt Synonym Gene Names
BHLHB31; CHF2; HERP2; HESR1; HRT1; CHF-2; bHLHb31; HESR-1; HRT-1; hHRT1 [Similar Products]
NCBI Summary for HEY1
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for HEY1
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).
Research Articles on HEY1
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Products associated with anti-HEY1 antibody
Pathways associated with anti-HEY1 antibody
Diseases associated with anti-HEY1 antibody
Organs/Tissues associated with anti-HEY1 antibody
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