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anti-C1R antibody :: Rabbit HIC2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9207189
Western Blot (WB)
Unit / Price
0.1 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HIC2 (C1R), Polyclonal Antibody

★Popular Item★
 Also Known As   

HIC2 Antibody

 Product Synonym Names    Complement C1r subcomponent; Complement component 1 subcomponent r; Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain; C1R
 Product Gene Name   

anti-C1R antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    421-480
 OMIM    216950
 3D Structure    ModBase 3D Structure for P00736
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Purity/Purification    Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
 Concentration    1mg/ml (lot specific)
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 Cellular Location    Secreted
    
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 Preparation and Storage    Store at -20 degree C.Stable for 12 months from date of receipt
 Other Notes    Small volumes of anti-C1R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-C1R antibody

   C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
 Product Categories/Family for anti-C1R antibody    Immunology
 Applications Tested/Suitable for anti-C1R antibody   

Western Blot (WB)

 Application Notes for anti-C1R antibody    WB~~ 1:1000
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 Western Blot (WB) of anti-C1R antibody    Anti-HIC2 Antibody at 1:1000 dilution + HeLa whole cell lysates

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution

Predicted band size : 66 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
anti-C1R antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for C1R. It may not necessarily be applicable to this product.
 NCBI GI #    66347875
 NCBI GeneID    715
 NCBI Accession #    NP_001724.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001733.4 [Other Products]
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 UniProt Primary Accession #    P00736 [Other Products]
 UniProt Secondary Accession #    Q68D77; Q8J012; A6NJQ8 [Other Products]
 UniProt Related Accession #    P00736 [Other Products]
 Molecular Weight    66,64 KDa
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 NCBI Official Full Name    complement C1r subcomponent
 NCBI Official Synonym Full Names    complement component 1, r subcomponent
 NCBI Official Symbol    C1R [Similar Products]
 NCBI Protein Information    complement C1r subcomponent
 UniProt Protein Name    Complement C1r subcomponent
 UniProt Synonym Protein Names   
Complement component 1 subcomponent r
 Protein Family    Complement C1r subcomponent
 UniProt Gene Name    C1R [Similar Products]
 UniProt Entry Name    C1R_HUMAN
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 UniProt Comments for C1R    C1R: C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system. Belongs to the peptidase S1 family.

Protein type: Protease; EC 3.4.21.41

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: extracellular region

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity; calcium ion binding

Biological Process: innate immune response; immune response; proteolysis; complement activation, classical pathway; complement activation

Disease: Complement Component C1r/c1s Deficiency
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Product References and Citations for anti-C1R antibody

   Leytus S.P.,et al.Biochemistry 25:4855-4863(1986).
Journet A.,et al.Biochem. J. 240:783-787(1986).
Nakagawa M.,et al.Ann. Hum. Genet. 67:207-215(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Scherer S.E.,et al.Nature 440:346-351(2006).
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 Research Articles on C1R    1. C1r specificity is well suited to its cleavage targets and that efficient cleavage of C1s is achieved through both active site and exosite contributions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-C1R antibodyDiseases associated with anti-C1R antibody
 Products by Pathway  Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 COMPLEMENT COMPONENT C1r/C1s DEFICIENCY Antibodies  >66 publications with C1R and COMPLEMENT COMPONENT C1r/C1s DEFICIENCY
 Cardiovascular Diseases Antibodies  >56 publications with C1R and Cardiovascular Diseases
 Inflammation Antibodies  >47 publications with C1R and Inflammation
 Nervous System Diseases Antibodies  >24 publications with C1R and Nervous System Diseases
 Kidney Diseases Antibodies  >18 publications with C1R and Kidney Diseases
 Necrosis Antibodies  >18 publications with C1R and Necrosis
 Liver Diseases Antibodies  >15 publications with C1R and Liver Diseases
 Edema Antibodies  >13 publications with C1R and Edema
 Disease Models, Animal Antibodies  >12 publications with C1R and Disease Models, Animal
 Heart Diseases Antibodies  >10 publications with C1R and Heart Diseases
Organs/Tissues associated with anti-C1R antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >255 publications with C1R and Blood
 Bone Antibodies  >59 publications with C1R and Bone
 Liver Antibodies  >43 publications with C1R and Liver
 Skin Antibodies  >31 publications with C1R and Skin
 Vascular Antibodies  >31 publications with C1R and Vascular
 Brain Antibodies  >29 publications with C1R and Brain
 Kidney Antibodies  >26 publications with C1R and Kidney
 Embryonic Tissue Antibodies  >24 publications with C1R and Embryonic Tissue
 Lung Antibodies  >19 publications with C1R and Lung
 Muscle Antibodies  >17 publications with C1R and Muscle
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