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anti-HINT1 antibody :: Rabbit HINT1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151397
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HINT1, Polyclonal Antibody

 Also Known As   

HINT1 Antibody

 Product Synonym Names    HINT1; HINT; NMAN; PKCI-1; PRKCNH1; HINT; PKCI1; Histidine triad nucleotide-binding protein 1; Protein kinase C inhibitor 1; histidine triad nucleotide binding protein 1
 Product Gene Name   

anti-HINT1 antibody

[Similar Products]
 Antibody/Peptide Pairs    HINT1 peptide (MBS152660) is used for blocking the activity of HINT1 antibody (MBS151397)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 601314
 3D Structure    ModBase 3D Structure for P49773
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    HINT1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    HINT1 antibody was raised against a 17 amino acid synthetic peptide near the center of the human HINT1.
 Buffer    HINT1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    HINT1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-HINT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HINT1 antibody

   HINT1 Antibody: Histidine triad nucleotide-binding protein 1 (HINT1) is a member of the histidine triad (HIT) protein family, a group of small nucleotide-binding and -hydrolyzing proteins. HINT1 interacts with several diverse proteins and has been suggested to have tumor suppressive activities. HINT1 catalyzes the hydrolysis of adenosine 5'-monophoramidate substrates such as AMP-morpholidate, but its enzymatic function does not appear to play a role in its tumor suppression. Recent experiments demonstrate that HINT1 forms a complex with POSH and JNK in vivo, inhibiting AP-1 activity and the phosphorylation of c-Jun, and this action could contribute to the tumor suppressor activity of HINT1. Other studies raise the possibility of HINT1 as a candidate gene for schizophrenia.
 Applications Tested/Suitable for anti-HINT1 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

 Application Notes for anti-HINT1 antibody    HINT1 antibody can be used for detection of HINT1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 2.5 mug/mL.
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 Western Blot (WB) of anti-HINT1 antibody    Western blot analysis of HINT1 in Jurkat lysate with HINT1 antibody at (A) 1 and (B) 2 μg/mL.
anti-HINT1 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-HINT1 antibody    Immunocytochemistry of HINT1 in Jurkat cells with HINT1 antibody at 2.5 μg/mL.
anti-HINT1 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for HINT1. It may not necessarily be applicable to this product.
 NCBI GI #    4885413
 NCBI GeneID    3094
 NCBI Accession #    NP_005331 [Other Products]
 NCBI GenBank Nucleotide #    NM_005340.6 [Other Products]
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 UniProt Primary Accession #    P49773 [Other Products]
 UniProt Secondary Accession #    Q9H5W8 [Other Products]
 UniProt Related Accession #    P49773 [Other Products]
 Molecular Weight    13,802 Da
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 NCBI Official Full Name    histidine triad nucleotide-binding protein 1
 NCBI Official Synonym Full Names    histidine triad nucleotide binding protein 1
 NCBI Official Symbol    HINT1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    histidine triad nucleotide-binding protein 1; protein kinase C inhibitor 1; adenosine 5'-monophosphoramidase; protein kinase C-interacting protein 1
 UniProt Protein Name    Histidine triad nucleotide-binding protein 1
 UniProt Synonym Protein Names   
Adenosine 5'-monophosphoramidase; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1; PKCI-1
 Protein Family    Adenylylsulfatase
 UniProt Gene Name    HINT1 [Similar Products]
 UniProt Synonym Gene Names    HINT; PKCI1; PRKCNH1; PKCI-1 [Similar Products]
 UniProt Entry Name    HINT1_HUMAN
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 NCBI Summary for HINT1    The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]
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 UniProt Comments for HINT1    HINT1: Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha- acetyl lysine methyl ester and AMP-NH2. Belongs to the HINT family.

Protein type: Hydrolase; Cytoskeletal; EC 3.-.-.-

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: cytoskeleton; cytoplasm; histone deacetylase complex; plasma membrane; nucleus

Molecular Function: protein kinase C binding; hydrolase activity; nucleotide binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; purine ribonucleotide catabolic process; signal transduction

Disease: Neuromyotonia And Axonal Neuropathy, Autosomal Recessive
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 Research Articles on HINT1    1. Study gives suggestive evidence that HINT1 rs3852209 may be related to smoking status in Chinese men.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HINT1 antibodyDiseases associated with anti-HINT1 antibody
 Reference Product  PubMed Publications
 SRC antibody  >5 publications with HINT1 and SRC
 SP1 antibody  >2 publications with HINT1 and SP1
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >14 publications with HINT1 and Schizophrenia
 Nervous System Diseases Antibodies  >11 publications with HINT1 and Nervous System Diseases
 Pain Antibodies  >9 publications with HINT1 and Pain
 Brain Diseases Antibodies  >5 publications with HINT1 and Brain Diseases
 Liver Neoplasms Antibodies  >5 publications with HINT1 and Liver Neoplasms
 Gastrointestinal Diseases Antibodies  >4 publications with HINT1 and Gastrointestinal Diseases
 Cardiovascular Diseases Antibodies  >3 publications with HINT1 and Cardiovascular Diseases
 Inherited Peripheral Neuropathy Antibodies  >3 publications with HINT1 and Inherited Peripheral Neuropathy
 Neoplasms, Experimental Antibodies  >3 publications with HINT1 and Neoplasms, Experimental
 Inflammation Antibodies  >2 publications with HINT1 and Inflammation
Organs/Tissues associated with anti-HINT1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >24 publications with HINT1 and Brain
 Liver Antibodies  >11 publications with HINT1 and Liver
 Blood Antibodies  >6 publications with HINT1 and Blood
 Skin Antibodies  >3 publications with HINT1 and Skin
 Embryonic Tissue Antibodies  >3 publications with HINT1 and Embryonic Tissue
 Bone Antibodies  >3 publications with HINT1 and Bone
 Muscle Antibodies  >3 publications with HINT1 and Muscle
 Kidney Antibodies  >3 publications with HINT1 and Kidney
 Eye Antibodies  >2 publications with HINT1 and Eye
 Lung Antibodies  >2 publications with HINT1 and Lung
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