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anti-HIST1H1D antibody :: Rabbit anti-Human HIST1H1D Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9205124
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HIST1H1D, Polyclonal Antibody

★Popular Item★
 Also Known As   

HIST1H1D Antibody (Center)

 Product Synonym Names    Histone H13; Histone H1c; Histone H1s-2; HIST1H1D; H1F3
 Product Gene Name   

anti-HIST1H1D antibody

[Similar Products]
 Antibody/Peptide Pairs    HIST1H1D peptide (MBS9220157) is used for blocking the activity of HIST1H1D antibody (MBS9205124)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    135-164
 OMIM    142210
 3D Structure    ModBase 3D Structure for P16402
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Clone Number    RB33733
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This HIST1H1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 amino acids from the Central region of human HIST1H1D.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Function    Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
 Cellular Location    Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in euchromatin. According to PubMed:10997781 is associated with inactive chromatin
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-HIST1H1D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HIST1H1D antibody

   Histones are basic nuclear proteins responsible for
nucleosome structure of the chromosomal fiber in eukaryotes. Two
molecules of each of the four core histones (H2A, H2B, H3, and H4)
form an octamer, around which approximately 146 bp of DNA is
wrapped in repeating units, called nucleosomes. The linker histone,
H1, interacts with linker DNA between nucleosomes and functions in
the compaction of chromatin into higher order structures. This gene
is intronless and encodes a member of the histone H1 family.
Transcripts from this gene lack polyA tails but instead contain a
palindromic termination element. This gene is found in the large
histone gene cluster on chromosome 6.
 Applications Tested/Suitable for anti-HIST1H1D antibody   

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-HIST1H1D antibody    WB~~1:1000
IHC-P~~1:10~50
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 Western Blot (WB) of anti-HIST1H1D antibody    HIST1H1D Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the HIST1H1D antibody detected the HIST1H1D protein (arrow).
anti-HIST1H1D antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HIST1H1D antibody    HIST1H1D Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HIST1H1D Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
anti-HIST1H1D antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HIST1H1D. It may not necessarily be applicable to this product.
 NCBI GI #    4885377
 NCBI GeneID    3007
 NCBI Accession #    NP_005311.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005320.2 [Other Products]
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 UniProt Primary Accession #    P16402 [Other Products]
 UniProt Secondary Accession #    Q2M2I2; B2R751 [Other Products]
 UniProt Related Accession #    P16402 [Other Products]
 Molecular Weight    22350
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 NCBI Official Full Name    histone H1.3
 NCBI Official Synonym Full Names    histone cluster 1, H1d
 NCBI Official Symbol    HIST1H1D [Similar Products]
 NCBI Official Synonym Symbols   
H1D; H1.3; H1F3; H1s-2
[Similar Products]
 NCBI Protein Information    histone H1.3
 UniProt Protein Name    Histone H1.3
 UniProt Synonym Protein Names   
Histone H1c; Histone H1s-2
 UniProt Gene Name    HIST1H1D [Similar Products]
 UniProt Synonym Gene Names    H1F3 [Similar Products]
 UniProt Entry Name    H13_HUMAN
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 NCBI Summary for HIST1H1D    Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HIST1H1D    H1D: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: nuclear chromatin; nucleosome

Molecular Function: chromatin DNA binding

Biological Process: nucleosome assembly; nucleosome positioning
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Product References and Citations for anti-HIST1H1D antibody

   Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)
Soranzo, N., et al. PLoS Genet. 5 (4), E1000445 (2009) :
Sovio, U., et al. PLoS Genet. 5 (3), E1000409 (2009) :
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Lettre, G., et al. Nat. Genet. 40(5):584-591(2008)
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 Research Articles on HIST1H1D    1. Integration with apoptotic intermediates (via C-terminal tail interactions) may constitute a more generalized function of linker histone isoforms in apoptotic cascades.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HIST1H1D antibodyDiseases associated with anti-HIST1H1D antibody
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 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with HIST1H1D and Breast Neoplasms
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