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anti-HIST1H2AG antibody :: Rabbit anti-Human HIST1H2AG Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1499967
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HIST1H2AG, Polyclonal Antibody

★Popular Item★
 Also Known As   

HIST1H2AG Antibody

 Product Synonym Names    Histone H2A type 1; H2A.1; HIST1H2AG; H2AFP; HIST1H2AI; H2AFC; HIST1H2AK; H2AFD; HIST1H2AL; H2AFI; HIST1H2AM; H2AFN
 Product Gene Name   

anti-HIST1H2AG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602787
 3D Structure    ModBase 3D Structure for P0C0S8
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Histone H2A type 1 protrin (2-130aa)
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HIST1H2AG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HIST1H2AG antibody

   Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 Applications Tested/Suitable for anti-HIST1H2AG antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

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 Western Blot (WB) of anti-HIST1H2AG antibody    All lanes: HIST1H2AG Antibody at 4ug/ml+HL-60 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 14kDa
Observed band size: 14kDa

anti-HIST1H2AG antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HIST1H2AG antibody    Immunohistochemistry of paraffin-embedded human lung cancer using MBS1499967 at dilution 1:100
anti-HIST1H2AG antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-HIST1H2AG antibody    Immunohistochemistry of paraffin-embedded human testis using MBS1499967 at dilution 1:100
anti-HIST1H2AG antibody Immunohistochemistry (IHC) (IHC) image
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 Chromatin Immunoprecipitation (ChIP) of anti-HIST1H2AG antibody    Chromatin Immunoprecipitation Hela(1.2^106)were cross-linked with formaldehyde, sonicated, and immunoprecipitated with 4ug anti-HIST1H2AG or a control normal rabbit IgG . The resulting ChIP DNA was quantified using real-time PCR with primers against the PGK1 promoter.
anti-HIST1H2AG antibody Chromatin Immunoprecipitation (ChIP) (IP) image
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 Immunofluorescence (IF) of anti-HIST1H2AG antibody    Immunofluorescent analysis of Hela cells using MBS1499967 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-HIST1H2AG antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for HIST1H2AG. It may not necessarily be applicable to this product.
 NCBI GI #    4504239
 NCBI GeneID    8329
 NCBI Accession #    NP_003500.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003509.2 [Other Products]
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 UniProt Primary Accession #    P0C0S8 [Other Products]
 UniProt Secondary Accession #    P02261; Q2M1R2; Q76PA6 [Other Products]
 UniProt Related Accession #    P0C0S8 [Other Products]
 Molecular Weight    14,091 Da
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 NCBI Official Full Name    histone H2A type 1
 NCBI Official Synonym Full Names    histone cluster 1, H2ai
 NCBI Official Symbol    HIST1H2AI [Similar Products]
 NCBI Official Synonym Symbols   
H2A/c; H2AFC
[Similar Products]
 NCBI Protein Information    histone H2A type 1
 UniProt Protein Name    Histone H2A type 1
 UniProt Synonym Protein Names   
Histone H2A/p
 UniProt Gene Name    HIST1H2AG [Similar Products]
 UniProt Synonym Gene Names    H2AFP; H2A.1 [Similar Products]
 UniProt Entry Name    H2A1_HUMAN
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 NCBI Summary for HIST1H2AG    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
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 UniProt Comments for HIST1H2AG    H2A.1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: nuclear chromatin; nucleosome; nucleus

Molecular Function: DNA binding; enzyme binding; protein binding; protein heterodimerization activity

Biological Process: chromatin silencing
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HIST1H2AG antibodyOrgans/Tissues associated with anti-HIST1H2AG antibody
 Products by Pathway  Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram
 HDACs Deacetylate Histones Pathway antibodies  HDACs Deacetylate Histones Pathway Diagram
 RMTs Methylate Histone Arginines Pathway antibodies  RMTs Methylate Histone Arginines Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with HIST1H2AG and Bone
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