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anti-HIST1H2BC antibody :: Rabbit HIST1H2BC/HIST1H2BF Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9215123
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HIST1H2BC/HIST1H2BF, Polyclonal Antibody

★Popular Item★
 Also Known As   

HIST1H2BC/HIST1H2BF Antibody (N-term)

 Product Synonym Names    Histone H2B type 1-C/E/F/G/I; Histone H2B1 A; Histone H2Ba; H2B/a; Histone H2Bg; H2B/g; Histone H2Bh; H2B/h; Histone H2Bk; H2B/k; Histone H2Bl; H2B/l; HIST1H2BC; H2BFL
 Product Gene Name   

anti-HIST1H2BC antibody

[Similar Products]
 Antibody/Peptide Pairs    HIST1H2BC/HIST1H2BF peptide (MBS9219451) is used for blocking the activity of HIST1H2BC/HIST1H2BF antibody (MBS9215123)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    1-30
 OMIM    602798
 3D Structure    ModBase 3D Structure for P62807
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human (Predicted Reactivity: Xenopus, Mouse, Bovine, Monkey, Chicken, Zebrafish)
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 Specificity    This HIST1H2BC/HIST1H2BF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST1H2BC/HIST1H2BF.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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 Calculated MW    13906
 Function    Core component of nucleosome.Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
 Cellular location    Nucleus. Chromosome.
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 Preparation and Storage    Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-HIST1H2BC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HIST1H2BC antibody

   Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
 Applications Tested/Suitable for anti-HIST1H2BC antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-HIST1H2BC antibody    WB~~1:1000
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 Western Blot (WB) of anti-HIST1H2BC antibody    HIST1H2BC/HIST1H2BF Antibody (N-term) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the HIST1H2BC/HIST1H2BF antibody detected the HIST1H2BC/HIST1H2BF protein (arrow).
anti-HIST1H2BC antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for HIST1H2BC. It may not necessarily be applicable to this product.
 NCBI GI #    4504257
 NCBI GeneID    8339
 NCBI Accession #    NP_003509.1 [Other Products]
 NCBI Related Accession #    NP_003513.1; NP_003514.2; NP_003516.1; NP_003517.2; NP_066407.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003518.3 [Other Products]
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 UniProt Primary Accession #    P62807 [Other Products]
 UniProt Secondary Accession #    P02278; Q3B872; Q4VB69; Q93078; Q93080 [Other Products]
 UniProt Related Accession #    P62807 [Other Products]
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 NCBI Official Full Name    histone H2B type 1-C/E/F/G/I
 NCBI Official Synonym Full Names    histone cluster 1, H2bg
 NCBI Official Symbol    HIST1H2BG [Similar Products]
 NCBI Official Synonym Symbols   
H2B/a; H2BFA; H2B.1A; dJ221C16.8
[Similar Products]
 NCBI Protein Information    histone H2B type 1-C/E/F/G/I
 UniProt Protein Name    Histone H2B type 1-C/E/F/G/I
 UniProt Synonym Protein Names   
Histone H2B.1 A; Histone H2B.a; H2B/a; Histone H2B.g; H2B/g; Histone H2B.h; H2B/h; Histone H2B.k; H2B/k; Histone H2B.l; H2B/l
 Protein Family    Histone
 UniProt Gene Name    HIST1H2BC [Similar Products]
 UniProt Synonym Gene Names    H2BFL; H2B/a; H2B/g; H2B/h; H2B/k; H2B/l [Similar Products]
 UniProt Entry Name    H2B1C_HUMAN
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 NCBI Summary for HIST1H2BC    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jan 2015]
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 UniProt Comments for HIST1H2BC    H2B1C: a core component of the nucleoosome. The nucleosome, a basic organizational unit of chromosomal DNA, is octrameric, consisting of two molecules each of histones H2B, H2A, H3, H4. The octamer wraps approximately 147 bp of DNA. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: nucleoplasm; extracellular space; nucleosome; nucleus

Molecular Function: DNA binding; protein heterodimerization activity

Biological Process: nucleosome assembly; defense response to Gram-positive bacterium; establishment and/or maintenance of chromatin architecture; innate immune response in mucosa; antibacterial humoral response
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Product References and Citations for anti-HIST1H2BC antibody

   Kim, S.C., et al. Mol. Cell 23(4):607-618(2006)
Beck, H.C., et al. Mol. Cell Proteomics 5(7):1314-1325(2006)
Pavri, R., et al. Cell 125(4):703-717(2006)
Bonenfant, D., et al. Mol. Cell Proteomics 5(3):541-552(2006)
Siuti, N., et al. J. Proteome Res. 5(2):233-239(2006)
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 Research Articles on HIST1H2BC    1. Histone H2B antimicrobial peptides participate in the colonic defense against bacteria and fungi.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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