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Rabbit HIV1 protease Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS536030 anti-HIV1 protease antibody
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HIV1 protease, Polyclonal Antibody

★Popular Item★
 Also Known As   

HIV1 protease antibody

 Product Synonym Names    Polyclonal HIV1 protease; Anti-HIV1 protease; HIV 1 protease; HIV-1 protease
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q13285
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Binds to recombinant Protease (HIV -1). Not tested for sterility or endotoxin content.
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 Specificity    Human, Mouse, Rat; other species not tested. Please decide the specificity by homology.
 Purity/Purification    > 95% pure
 Form/Format    Supplied as a purified IgG in PBS buffer, >95% pure by SDS-PAGE analysis, with no preservatives added.
 Concentration    1.0mg/ml (lot specific)
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 Biological Significance    HIV-1 protease (HIV PR) is a retroviral aspartyl protease that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV PR cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. Without effective HIV PR, HIV virions remain uninfectious. Thus, mutation of HIV PR?s active site or inhibition of its activity disrupts HIV?s ability to replicate and infect additional cells, making HIV PR inhibition the subject of much pharmaceutical research.
 Immunogen    Full length recombinant Protease (HIV-1) expressed in E.coli Expression System
    
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 Preparation and Storage    Upon receipt store at -70 degree C
Shipping: Ships on dry ice.
 Other Notes    Small volumes of anti-HIV1 protease antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HIV1 protease antibody

   Rabbit polyclonal HIV1 protease antibody
 Product Categories/Family for anti-HIV1 protease antibody    Infectious Disease; Purified Polyclonal Antibodies
 Applications Tested/Suitable for anti-HIV1 protease antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-HIV1 protease antibody    If protein concentration is 1mg/ml, suggested starting dilutions are:
ELISA and Western Blot 1:500-1:1,000

Optimal dilutions must be determined by end user.
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NCBI/Uniprot data below describe general gene information for HIV1 protease. It may not necessarily be applicable to this product.
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 UniProt Primary Accession #    Q13285 [Other Products]
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 UniProt Comments for HIV1 protease    Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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