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anti-HK2 antibody :: Rabbit anti-Human HK2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7052049
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HK2, Polyclonal Antibody

★Popular Item★
 Also Known As   

HK2 Antibody

 Product Synonym Names    Hexokinase-2; Hexokinase type II; HK II; Muscle form hexokinase; HK2
 Product Gene Name   

anti-HK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    Z46376 mRNA
 3D Structure    ModBase 3D Structure for P52789
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Hexokinase-2 protein (334-526AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HK2 antibody

   cytosol, membrane, mitochondrial outer membrane, fructokinase activity, glucokinase activity, hexokinase activity, mannokinase activity, apoptotic mitochondrial changes, canonical glycolysis, cellular glucose homeostasis
 Applications Tested/Suitable for anti-HK2 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-HK2 antibody    WB: 1:500-1:5000
IF: 1:50-1:200
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 Western Blot (WB) of anti-HK2 antibody    Western Blot
Positive WB detected in: U87 whole cell lysate
All lanes: HK2 antibody at 4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
predicted band size: 103 kDa
observed band size: 103 kDa

anti-HK2 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-HK2 antibody    Immunofluorescent analysis of PC3 cells using MBS7052049 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-HK2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for HK2. It may not necessarily be applicable to this product.
 NCBI GI #    15553127
 NCBI GeneID    3099
 NCBI Accession #    NP_000180.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000189.4 [Other Products]
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 UniProt Primary Accession #    P52789 [Other Products]
 UniProt Secondary Accession #    Q8WU87; Q9UN82; D6W5J2 [Other Products]
 UniProt Related Accession #    P52789 [Other Products]
 Molecular Weight    102,380 Da
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 NCBI Official Full Name    hexokinase-2
 NCBI Official Synonym Full Names    hexokinase 2
 NCBI Official Symbol    HK2 [Similar Products]
 NCBI Official Synonym Symbols   
HKII; HXK2
[Similar Products]
 NCBI Protein Information    hexokinase-2
 UniProt Protein Name    Hexokinase-2
 UniProt Synonym Protein Names   
Hexokinase type II; HK II; Muscle form hexokinase
 Protein Family    Probable histidine kinase
 UniProt Gene Name    HK2 [Similar Products]
 UniProt Synonym Gene Names    HK II [Similar Products]
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 NCBI Summary for HK2    Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009]
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 UniProt Comments for HK2    HK2: a glycolytic enzyme that catalyzes the reaction ATP + D-hexose = ADP + D-hexose 6-phosphate. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. An allosteric enzyme inhibited by its product glucose-6-phosphate (Glc-6-P). The predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle. Acts as a ""glucose sensor"" by trapping glucose inside the cell by catalyzing its phosphorylation to produce Glc-6-P. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase). Genetic variations of HK2 do not appear to contribute to NIDDM.

Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: cytosol; membrane; mitochondrial outer membrane

Molecular Function: fructokinase activity; glucokinase activity; hexokinase activity; mannokinase activity; protein binding

Biological Process: apoptotic mitochondrial changes; cell glucose homeostasis; glucose transport; glycolysis
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 Research Articles on HK2    1. miR-181b directly inhibits the expression level of hexokinase 2 (HK2), a key enzyme that catalyzes the first step of glycolysis, through targeting its 3'-untranslated region.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HK2 antibodyPathways associated with anti-HK2 antibody
 Reference Product  PubMed Publications
 GPI antibody  >4 publications with HK2 and GPI
 PFKM antibody  >2 publications with HK2 and PFKM
 PFKL antibody  >1 publications with HK2 and PFKL
 C12orf5 antibody  >1 publications with HK2 and C12orf5
 PFKP antibody  >1 publications with HK2 and PFKP
 Products by Pathway  Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Butirosin And Neomycin Biosynthesis Pathway antibodies  Butirosin And Neomycin Biosynthesis Pathway Diagram
 Butirosin And Neomycin Biosynthesis Pathway antibodies  Butirosin And Neomycin Biosynthesis Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
Diseases associated with anti-HK2 antibodyOrgans/Tissues associated with anti-HK2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >210 publications with HK2 and Neoplasms
 Kidney Diseases Antibodies  >42 publications with HK2 and Kidney Diseases
 Hyperplasia Antibodies  >39 publications with HK2 and Hyperplasia
 Fibrosis Antibodies  >28 publications with HK2 and Fibrosis
 Breast Neoplasms Antibodies  >22 publications with HK2 and Breast Neoplasms
 Death Antibodies  >20 publications with HK2 and Death
 Cardiovascular Diseases Antibodies  >15 publications with HK2 and Cardiovascular Diseases
 Drug Toxicity Antibodies  >12 publications with HK2 and Drug Toxicity
 Neoplasms, Experimental Antibodies  >10 publications with HK2 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >9 publications with HK2 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >237 publications with HK2 and Prostate
 Blood Antibodies  >125 publications with HK2 and Blood
 Kidney Antibodies  >98 publications with HK2 and Kidney
 Muscle Antibodies  >27 publications with HK2 and Muscle
 Brain Antibodies  >21 publications with HK2 and Brain
 Liver Antibodies  >21 publications with HK2 and Liver
 Heart Antibodies  >16 publications with HK2 and Heart
 Embryonic Tissue Antibodies  >14 publications with HK2 and Embryonic Tissue
 Bone Antibodies  >12 publications with HK2 and Bone
 Lung Antibodies  >11 publications with HK2 and Lung
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