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anti-HK3 antibody :: Rabbit HK3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2525851
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HK3, Polyclonal Antibody

★Popular Item★
 Also Known As   

HK3 Polyclonal Antibody

 Product Synonym Names    HXK3; HKIII
 Product Gene Name   

anti-HK3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    142570
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    2.5mg/mL (lot specific)
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 Immunogen    Recombinant protein of human HK3
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HK3 antibody

   Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate.
 Applications Tested/Suitable for anti-HK3 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-HK3 antibody    IHC: 1:50-1:200
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 Immunohistochemistry (IHC) of anti-HK3 antibody    Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using HK3 Polyclonal Antibody at dilution 1:40
anti-HK3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-HK3 antibody    Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using HK3 Polyclonal Antibody at dilution 1:40
anti-HK3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HK3. It may not necessarily be applicable to this product.
 NCBI GI #    194097330
 NCBI GeneID    3101
 NCBI Accession #    NP_002106.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002115.2 [Other Products]
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 UniProt Secondary Accession #    Q8N1E7 [Other Products]
 UniProt Related Accession #    P52790 [Other Products]
 Molecular Weight    99,025 Da
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 NCBI Official Full Name    hexokinase-3
 NCBI Official Synonym Full Names    hexokinase 3 (white cell)
 NCBI Official Symbol    HK3 [Similar Products]
 NCBI Official Synonym Symbols   
HXK3; HKIII
[Similar Products]
 NCBI Protein Information    hexokinase-3; ATP:D-hexose 6-phosphotransferase; HK III; hexokinase type III
 UniProt Protein Name    Hexokinase-3
 UniProt Synonym Protein Names   
Hexokinase type III; HK III
 Protein Family    Probable histidine kinase
 UniProt Gene Name    HK3 [Similar Products]
 UniProt Synonym Gene Names    HK III [Similar Products]
 UniProt Entry Name    HXK3_HUMAN
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 NCBI Summary for HK3    Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]
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 UniProt Comments for HK3    HK3: a glycolytic enzyme that catalyzes the reaction ATP + D-hexose = ADP + D-hexose 6-phosphate. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. An allosteric enzyme inhibited by its product glucose-6-phosphate (Glc-6-P). Acts as a ""glucose sensor"" by trapping glucose inside the cell by catalyzing its phosphorylation to produce Glc-6-P. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

Protein type: EC 2.7.1.1; Transferase; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Enzyme, cellular metabolism; Kinase, other; Carbohydrate Metabolism - glycolysis and gluconeogenesis

Chromosomal Location of Human Ortholog: 5q35.2

Cellular Component: protein complex; mitochondrion; cytosol

Molecular Function: hexokinase activity; enzyme binding; mannokinase activity; hormone binding; fructokinase activity; glucokinase activity; ATP binding

Biological Process: hexose metabolic process; glycolysis; hexose transport; carbohydrate metabolic process; glucose 6-phosphate metabolic process; carbohydrate phosphorylation; cell glucose homeostasis; pathogenesis; glucose transport; transmembrane transport
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 Research Articles on HK3    1. Altogether, our data provide an explanation for low HK3 and KLF5 expression in particular AML subtype and establish these genes as novel CEBPA targets during neutrophil differentiation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HK3 antibodyPathways associated with anti-HK3 antibody
 Reference Product  PubMed Publications
 PFKFB2 antibody  >1 publications with HK3 and PFKFB2
 Products by Pathway  Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Butirosin And Neomycin Biosynthesis Pathway antibodies  Butirosin And Neomycin Biosynthesis Pathway Diagram
 Butirosin And Neomycin Biosynthesis Pathway antibodies  Butirosin And Neomycin Biosynthesis Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbohydrate Digestion And Absorption Pathway antibodies  Carbohydrate Digestion And Absorption Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
Diseases associated with anti-HK3 antibodyOrgans/Tissues associated with anti-HK3 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >10 publications with HK3 and Carcinoma
 Hyperplasia Antibodies  >7 publications with HK3 and Hyperplasia
 Skin Neoplasms Antibodies  >4 publications with HK3 and Skin Neoplasms
 Liver Neoplasms Antibodies  >2 publications with HK3 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with HK3 and Carcinoma, Hepatocellular
 Leukemia, Promyelocytic, Acute Antibodies  >2 publications with HK3 and Leukemia, Promyelocytic, Acute
 Liver Diseases Antibodies  >2 publications with HK3 and Liver Diseases
 Neoplasms, Experimental Antibodies  >1 publications with HK3 and Neoplasms, Experimental
 Carcinoma, Squamous Cell Antibodies  >1 publications with HK3 and Carcinoma, Squamous Cell
 Cell Transformation, Neoplastic Antibodies  >1 publications with HK3 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >54 publications with HK3 and Prostate
 Blood Antibodies  >24 publications with HK3 and Blood
 Brain Antibodies  >5 publications with HK3 and Brain
 Skin Antibodies  >5 publications with HK3 and Skin
 Testis Antibodies  >5 publications with HK3 and Testis
 Lung Antibodies  >3 publications with HK3 and Lung
 Muscle Antibodies  >2 publications with HK3 and Muscle
 Connective Tissue Antibodies  >1 publications with HK3 and Connective Tissue
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