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anti-HLA-DPA1 antibody :: Rabbit anti-Human HLA-DPA1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2529717
SDS-PAGE
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HLA-DPA1, Polyclonal Antibody

★Popular Item★
 Also Known As   

HLA-DPA1 Antibody

 Product Synonym Names    DP(W3), DP (W4), HLA DP1A, HLA DPA1, HLA SB alpha chain, HLADP, HLADPA1
 Product Gene Name   

anti-HLA-DPA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    142880
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen affinity purification
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 Immunogen    Fusion protein of HLA-DPA1
 Calculated Molecular Weight    60aa; 29kd
 Observed Molecular Weight    33kDa
 Buffer    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-168096 / sc-168097
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HLA-DPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HLA-DPA1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-HLA-DPA1 antibody    WB: 1:500-1:5000
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 SDS-PAGE of anti-HLA-DPA1 antibody    Raji cells were subjected to SDS PAGE followed by western blot with HLA-DPAI Antibody at dilution of 1:1000
anti-HLA-DPA1 antibody SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for HLA-DPA1. It may not necessarily be applicable to this product.
 NCBI GI #    335883187
 NCBI GeneID    3113
 NCBI Accession #    NP_001229454.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001242525.1 [Other Products]
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 UniProt Secondary Accession #    O19722; O46883; P01905; P79554; Q2Q060; Q2Q061; Q5EY03; Q5STP1; Q6DQK4; A9YWH7; B9UKH4 [Other Products]
 UniProt Related Accession #    P20036 [Other Products]
 Molecular Weight    29,381 Da
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 NCBI Official Full Name    HLA class II histocompatibility antigen, DP alpha 1 chain
 NCBI Official Synonym Full Names    major histocompatibility complex, class II, DP alpha 1
 NCBI Official Symbol    HLA-DPA1 [Similar Products]
 NCBI Official Synonym Symbols   
PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DP1A
[Similar Products]
 NCBI Protein Information    HLA class II histocompatibility antigen, DP alpha 1 chain; HLA-SB alpha chain; MHC class II DP3-alpha; MHC class II HLA-DPA1 antigen; MHC class II antigen; Primed lymphocyte test-1
 UniProt Protein Name    HLA class II histocompatibility antigen, DP alpha 1 chain
 UniProt Synonym Protein Names   
DP(W3); DP(W4); HLA-SB alpha chain; MHC class II DP3-alpha; MHC class II DPA1
 Protein Family    HLA class II histocompatibility antigen
 UniProt Gene Name    HLA-DPA1 [Similar Products]
 UniProt Synonym Gene Names    HLA-DP1A; HLASB [Similar Products]
 UniProt Entry Name    DPA1_HUMAN
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 NCBI Summary for HLA-DPA1    HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HLA-DPA1    HLA-DPA1: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading. Belongs to the MHC class II family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; cell surface; integral to plasma membrane; lysosomal membrane; plasma membrane; endosome membrane; trans-Golgi network membrane; MHC class II protein complex

Molecular Function: MHC class II receptor activity; peptide antigen binding

Biological Process: positive regulation of interferon-gamma production; cytokine and chemokine mediated signaling pathway; T cell costimulation; antigen processing and presentation of exogenous peptide antigen via MHC class II; positive regulation of T cell proliferation; immune response; positive regulation of T cell activation; T cell receptor signaling pathway
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 Research Articles on HLA-DPA1    1. The study suggests that HLA-DPA1/B1 loci are candidate susceptibility regions that have some marker single nucleotide polymorphisms for both chronic hepatitis C virus infection and F protein generation in the Han Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HLA-DPA1 antibodyDiseases associated with anti-HLA-DPA1 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Hepatitis B, Chronic Antibodies  >17 publications with HLA-DPA1 and Hepatitis B, Chronic
 Lung Diseases Antibodies  >6 publications with HLA-DPA1 and Lung Diseases
 Nervous System Diseases Antibodies  >5 publications with HLA-DPA1 and Nervous System Diseases
 Fibrosis Antibodies  >3 publications with HLA-DPA1 and Fibrosis
 Skin Diseases Antibodies  >3 publications with HLA-DPA1 and Skin Diseases
 Heart Diseases Antibodies  >2 publications with HLA-DPA1 and Heart Diseases
 Kidney Diseases Antibodies  >2 publications with HLA-DPA1 and Kidney Diseases
 Inflammation Antibodies  >2 publications with HLA-DPA1 and Inflammation
 Adenocarcinoma Antibodies  >2 publications with HLA-DPA1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >2 publications with HLA-DPA1 and Neoplasms, Experimental
Organs/Tissues associated with anti-HLA-DPA1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >28 publications with HLA-DPA1 and Blood
 Liver Antibodies  >12 publications with HLA-DPA1 and Liver
 Bone Antibodies  >7 publications with HLA-DPA1 and Bone
 Bone Marrow Antibodies  >7 publications with HLA-DPA1 and Bone Marrow
 Lung Antibodies  >4 publications with HLA-DPA1 and Lung
 Heart Antibodies  >2 publications with HLA-DPA1 and Heart
 Vascular Antibodies  >2 publications with HLA-DPA1 and Vascular
 Spleen Antibodies  >1 publications with HLA-DPA1 and Spleen
 Kidney Antibodies  >1 publications with HLA-DPA1 and Kidney
 Mammary Gland Antibodies  >1 publications with HLA-DPA1 and Mammary Gland
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