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anti-HLA-A antibody :: Rabbit HLA class I (HLA-A) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7600128
Unit / Price
0.1 mg  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HLA class I (HLA-A), Polyclonal Antibody

★Popular Item★
 Also Known As   

HLA class I (HLA-A) Rabbit Polyclonal

 Product Synonym Names    HLA A, HLAA, HLA-A
 Product Gene Name   

anti-HLA-A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS7600128 Technical Datasheet    Technical Datasheet PDF
 OMIM    142800
 3D Structure    ModBase 3D Structure for P04439
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human; Mouse; other species are not tested.
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 Specificity    Please decide specifity by homology.
 Purity/Purification    >=95% as determined by SDS-PAGE
Immunogen Affinity Purified
 Form/Format    Liquid
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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 Immunogen    Major histocompatibility complex, class I, A
 Calculated MW    44 kDa
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 Preparation and Storage    -20C for 24 months (Avoid repeated freeze / thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HLA-A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HLA-A antibody   

ELISA, WB, IHC.

 Application Notes for anti-HLA-A antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Immunohistochemistry IHC of anti-HLA-A antibody    Immunohistochemistry of paraffin-embedded human esophagus using MBS7600128 (HLA class (HLA-A antibody) at dilution of 1:100
anti-HLA-A antibody Immunohistochemistry IHC (IHC) image
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 Western Blot WB of anti-HLA-A antibody    HepG2 cells were subjected to SDS PAGE followed by western blot with MBS7600128(HLA class I(HLA-A antibody) at dilution of 1:1000
anti-HLA-A antibody Western Blot WB (WB) image
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NCBI/Uniprot data below describe general gene information for HLA-A. It may not necessarily be applicable to this product.
 NCBI GI #    24797067
 NCBI GeneID    3105
 NCBI Accession #    NP_002107.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002116.7 [Other Products]
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 UniProt Primary Accession #    P04439 [Other Products]
 UniProt Secondary Accession #    O19619; P06338; P10313; P30444; P30445; P30446; P30514; Q29680; Q29837; Q29899; Q95352 [Other Products]
 UniProt Related Accession #    P01892; P13746; P18462; P30443; P30447; P30453; P30455; P30456; P30457; P30459 [Other Products]
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 NCBI Official Full Name    HLA class I histocompatibility antigen, A-1 alpha chain
 NCBI Official Synonym Full Names    major histocompatibility complex, class I, A
 NCBI Official Symbol    HLA-A [Similar Products]
 NCBI Official Synonym Symbols   
HLAA; Aw-33; Aw-74; HLA-A11; HLA-A33; HLA-DQB1; HLA-DRB1
[Similar Products]
 NCBI Protein Information    HLA class I histocompatibility antigen, A-1 alpha chain
 UniProt Protein Name    HLA class I histocompatibility antigen, A-2 alpha chain
 UniProt Synonym Protein Names   
MHC class I antigen A*2
 Protein Family    HLA class I histocompatibility antigen
 UniProt Gene Name    HLA-A [Similar Products]
 UniProt Synonym Gene Names    HLAA [Similar Products]
 UniProt Entry Name    1A02_HUMAN
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 NCBI Summary for HLA-A    HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HLA-A    HLAA: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family.

Protein type: Membrane protein, integral; Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cell surface; early endosome membrane; endoplasmic reticulum; Golgi apparatus; Golgi medial cisterna; Golgi membrane; integral to plasma membrane; membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane

Molecular Function: beta-2-microglobulin binding; peptide antigen binding; protein binding; receptor binding; T cell receptor binding; TAP binding

Biological Process: antibacterial humoral response; antigen processing and presentation; antigen processing and presentation of endogenous peptide antigen via MHC class I; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; defense response to Gram-positive bacterium; detection of bacterium; immune response; positive regulation of interferon-gamma production; positive regulation of T cell cytokine production; positive regulation of T cell mediated cytotoxicity; protection from natural killer cell mediated cytotoxicity; regulation of defense response to virus by virus; regulation of immune response; viral reproduction

Disease: Severe Cutaneous Adverse Reaction, Susceptibility To
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 Research Articles on HLA-A    1. HLA-A* 02:07 is likely an important genetic risk factor for postmenopausal osteoporosis in the Han Chinese population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HLA-A antibodyOrgans/Tissues associated with anti-HLA-A antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7714 publications with HLA-A and Blood
 Kidney Antibodies  >1070 publications with HLA-A and Kidney
 Bone Antibodies  >1024 publications with HLA-A and Bone
 Bone Marrow Antibodies  >960 publications with HLA-A and Bone Marrow
 Liver Antibodies  >518 publications with HLA-A and Liver
 Skin Antibodies  >477 publications with HLA-A and Skin
 Lung Antibodies  >419 publications with HLA-A and Lung
 Heart Antibodies  >224 publications with HLA-A and Heart
 Lymph Antibodies  >194 publications with HLA-A and Lymph
 Lymph Node Antibodies  >192 publications with HLA-A and Lymph Node
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