NP_002118.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
HLA class I histocompatibility antigen, alpha chain G
NCBI Official Synonym Full Names
major histocompatibility complex, class I, G
NCBI Official Synonym Symbols
NCBI Protein Information
HLA class I histocompatibility antigen, alpha chain G
UniProt Protein Name
HLA class I histocompatibility antigen, alpha chain G
UniProt Synonym Protein Names
HLA G antigen; MHC class I antigen G
UniProt Synonym Gene Names
UniProt Entry Name
HLAG_HUMAN
NCBI Summary for HLA-G
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
UniProt Comments for HLA-G
HLA-G: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells. Belongs to the MHC class I family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: early endosome membrane; Golgi membrane; membrane; MHC class I protein complex; phagocytic vesicle membrane; plasma membrane
Molecular Function: antigen binding; peptide antigen binding; protein homodimerization activity; receptor binding
Biological Process: antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; antigen processing and presentation of peptide antigen via MHC class I; cellular defense response; cytokine and chemokine mediated signaling pathway; immune response-inhibiting cell surface receptor signaling pathway; negative regulation of immune response; negative regulation of T cell proliferation; positive regulation of interleukin-12 production; positive regulation of regulatory T cell differentiation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction; regulation of immune response
Disease: Asthma, Susceptibility To
Research Articles on HLA-G
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Products associated with anti-HLA-G antibody
Pathways associated with anti-HLA-G antibody
Diseases associated with anti-HLA-G antibody
Organs/Tissues associated with anti-HLA-G antibody
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