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anti-HMG1 antibody :: Rabbit HMG1 / HMGB1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242933
Unit / Price
0.05 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HMG1 / HMGB1, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal (IgG) to Human HMG1 / HMGB1

 Product Synonym Names    Anti-HMG1 / HMGB1 Antibody (aa131-180) IHC-plus; HMGB1; Amphoterin; High mobility group protein B1; High mobility group box 1; High mobility group protein 1; HMG1; HMG3; SBP-1; High-mobility group box 1; HMG-1; Human HMG1; HMGB1
 Product Gene Name   

anti-HMG1 antibody

[Similar Products]
 Product Synonym Gene Name    HMGB1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    163905
 3D Structure    ModBase 3D Structure for P09429
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    HMGB1 Antibody detects endogenous levels of total HMGB1 protein.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human HMGB1 (aa131-180).
 Immunogen    HMG1 / HMGB1 antibody was raised against synthetic peptide from human HMGB1 (aa131-180).
 Antigen Modification    aa131-180
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-HMG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HMG1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-HMG1 antibody    ELISA (1:20000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)
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 Immunohistochemistry (IHC) of anti-HMG1 antibody    Anti-HMGB1 antibody IHC of human, uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-HMG1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-HMG1 antibody    Western blot of extracts from Jurkat/HepG2/COLO205/293 cells, using HMGB1 Antibody. The lane on the right is treated with the synthesized peptide.
anti-HMG1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for HMG1. It may not necessarily be applicable to this product.
 NCBI GI #    4504425
 NCBI GeneID    3146
 NCBI Accession #    NP_002119.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002128.4 [Other Products]
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 UniProt Primary Accession #    P09429 [Other Products]
 UniProt Secondary Accession #    Q14321; Q5T7C3; Q6IBE1; A5D8W9 [Other Products]
 UniProt Related Accession #    P09429 [Other Products]
 Molecular Weight    24,894 Da
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 NCBI Official Full Name    high mobility group protein B1
 NCBI Official Synonym Full Names    high mobility group box 1
 NCBI Official Symbol    HMGB1 [Similar Products]
 NCBI Official Synonym Symbols   
HMG1; HMG3; SBP-1
[Similar Products]
 NCBI Protein Information    high mobility group protein B1; HMG-1; Amphoterin; high-mobility group box 1; high mobility group protein 1; Sulfoglucuronyl carbohydrate binding protein; high-mobility group (nonhistone chromosomal) protein 1
 UniProt Protein Name    High mobility group protein B1
 UniProt Synonym Protein Names   
High mobility group protein 1; HMG-1
 Protein Family    High mobility group protein
 UniProt Gene Name    HMGB1 [Similar Products]
 UniProt Synonym Gene Names    HMG1; HMG-1 [Similar Products]
 UniProt Entry Name    HMGB1_HUMAN
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 UniProt Comments for HMG1    HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Belongs to the HMGB family.

Protein type: DNA repair, damage; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: nucleoplasm; extracellular space; cell surface; transcriptional repressor complex; extracellular region; condensed chromosome; nucleus

Molecular Function: RAGE receptor binding; protein binding; double-stranded DNA binding; cytokine activity; damaged DNA binding; chromatin binding; transcription factor binding; DNA bending activity; transcription factor activity; single-stranded DNA binding; chemoattractant activity

Biological Process: negative regulation of transcriptional preinitiation complex assembly; DNA topological change; V(D)J recombination; positive regulation of apoptosis; apoptosis; positive regulation of caspase activity; base-excision repair, DNA ligation; negative regulation of transcription from RNA polymerase II promoter; DNA recombination; chromatin remodeling; regulation of transcription from RNA polymerase II promoter; myeloid dendritic cell activation; inflammatory response to antigenic stimulus; positive chemotaxis; DNA ligation during DNA repair; innate immune response; dendritic cell chemotaxis; positive regulation of transcription from RNA polymerase II promoter; DNA fragmentation during apoptosis; neurite development; positive regulation of DNA binding; cell structure disassembly during apoptosis
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 Research Articles on HMG1    1. Nrf-2 translocation could play a part in induction of Nrf-2-HO-1-HMGB1 axis regulation in myocardial reperfusion injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HMG1 antibodyPathways associated with anti-HMG1 antibody
 Reference Product  PubMed Publications
 TNF antibody  >449 publications with HMG1 and TNF
 TLR4 antibody  >342 publications with HMG1 and TLR4
 TP53 antibody  >8 publications with HMG1 and TP53
 AGER antibody  >4 publications with HMG1 and AGER
 DIF antibody  >2 publications with HMG1 and DIF
 PLAT antibody  >1 publications with HMG1 and PLAT
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of DNA Fragmentation Factor Pathway antibodies  Activation Of DNA Fragmentation Factor Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Induced DNA Fragmentation Pathway antibodies  Apoptosis Induced DNA Fragmentation Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
Diseases associated with anti-HMG1 antibodyOrgans/Tissues associated with anti-HMG1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1295 publications with HMG1 and Inflammation
 Necrosis Antibodies  >728 publications with HMG1 and Necrosis
 Sepsis Antibodies  >484 publications with HMG1 and Sepsis
 Disease Models, Animal Antibodies  >376 publications with HMG1 and Disease Models, Animal
 Lung Diseases Antibodies  >210 publications with HMG1 and Lung Diseases
 Lung Injury Antibodies  >189 publications with HMG1 and Lung Injury
 Liver Diseases Antibodies  >171 publications with HMG1 and Liver Diseases
 Heart Diseases Antibodies  >126 publications with HMG1 and Heart Diseases
 Myocardial Ischemia Antibodies  >103 publications with HMG1 and Myocardial Ischemia
 Kidney Diseases Antibodies  >83 publications with HMG1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1089 publications with HMG1 and Blood
 Liver Antibodies  >403 publications with HMG1 and Liver
 Lung Antibodies  >359 publications with HMG1 and Lung
 Brain Antibodies  >299 publications with HMG1 and Brain
 Vascular Antibodies  >285 publications with HMG1 and Vascular
 Muscle Antibodies  >172 publications with HMG1 and Muscle
 Heart Antibodies  >158 publications with HMG1 and Heart
 Kidney Antibodies  >153 publications with HMG1 and Kidney
 Bone Antibodies  >124 publications with HMG1 and Bone
 Thymus Antibodies  >104 publications with HMG1 and Thymus
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