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anti-HMGB1 antibody :: Rabbit anti-Human HMG1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS612185 anti-HMGB1 antibody
Unit / Price
0.2 mg  /  $625 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HMG1 (HMGB1), Polyclonal Antibody

 Also Known As   

HMG1 (HMGB1, High Mobility Group, HMG Transcription Factor Box1, Amphoterin, Sulfoglucuronyl Carbohydrate Binding Protein, SBP-1, HMG3)

 Product Synonym Names    Anti -HMG1 (HMGB1, High Mobility Group, HMG Transcription Factor Box1, Amphoterin, Sulfoglucuronyl Carbohydrate Binding Protein, SBP-1, HMG3)
 Product Gene Name   

anti-HMGB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 13; NC_000013.10 (31032877..31191942, complement). Location: 13q12
 OMIM    163905
 3D Structure    ModBase 3D Structure for P09429
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human HMGB1/HMG 1, Mr ~32kD. Species Crossreactivity: Broad species crossreactivity is expected.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide, before the addition of glycerol to 30%.
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 Immunogen    HMGB1/HMG 1 protein purified from porcine thymus glands.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-HMGB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HMGB1 antibody

   HMG-1 (High-Mobility-Group protein, amphoterin) is a highly conserved protein with more than 95% amino acid identity between rodent and human HMG-1. It is a prevalent non-histone chromatin component and a non-sequence specific DNA binding protein. HMG-1 consists of two homologous HMG boxes rich in basic amino acids and an acidic tail at the carboxy-terminus. HMG-1 is involved in the regulation of chromatin structure as well as being involved, either as positive or negative factors with various aspects of DNA replication, transcription, repair, and ligation. HMG-1, identified as a membrane associated protein termed "amphoterin," mediates neurite outgrowth, tumor outgrowth, and metastasis. It participates in plasminogen activation and is recognized as a late mediator of endotoxin lethality in mice.
 Product Categories/Family for anti-HMGB1 antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-HMGB1 antibody   

Western Blot (WB)

 Application Notes for anti-HMGB1 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 1-2ug/ml detects HMGB1/HMG1 from acid extracts of HeLa cells. Acid extracts of HeLa cells were resolved by electrophoresis, transferred to nitrocellulose and probed with H6202-02 (2ug/ml). Proteins were visualized using IgG (HRP) goat anti-rabbit and a chemiluminescence detection system.
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NCBI/Uniprot data below describe general gene information for HMGB1. It may not necessarily be applicable to this product.
 NCBI GI #    4504425
 NCBI GeneID    3146
 NCBI Accession #    NP_002119.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002128.4 [Other Products]
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 UniProt Primary Accession #    P09429 [Other Products]
 UniProt Secondary Accession #    Q14321; Q5T7C3; Q6IBE1; A5D8W9 [Other Products]
 UniProt Related Accession #    P09429 [Other Products]
 Molecular Weight    24,894 Da [Similar Products]
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 NCBI Official Full Name    high mobility group protein B1
 NCBI Official Synonym Full Names    high mobility group box 1
 NCBI Official Symbol    HMGB1 [Similar Products]
 NCBI Official Synonym Symbols   
HMG1; HMG3; SBP-1
[Similar Products]
 NCBI Protein Information    high mobility group protein B1; HMG-1; Amphoterin; high-mobility group box 1; high mobility group protein 1; Sulfoglucuronyl carbohydrate binding protein; high-mobility group (nonhistone chromosomal) protein 1
 UniProt Protein Name    High mobility group protein B1
 UniProt Synonym Protein Names   
High mobility group protein 1
 Protein Family    HMG1/2-like protein
 UniProt Gene Name    HMGB1 [Similar Products]
 UniProt Synonym Gene Names    HMG1; HMG-1 [Similar Products]
 UniProt Entry Name    HMGB1_HUMAN
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 UniProt Comments for HMGB1    HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Belongs to the HMGB family.

Protein type: DNA repair, damage; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: nucleoplasm; extracellular space; cell surface; transcriptional repressor complex; extracellular region; condensed chromosome; nucleus

Molecular Function: RAGE receptor binding; protein binding; double-stranded DNA binding; damaged DNA binding; cytokine activity; chromatin binding; transcription factor activity; transcription factor binding; DNA bending activity; single-stranded DNA binding; chemoattractant activity

Biological Process: negative regulation of transcriptional preinitiation complex assembly; V(D)J recombination; DNA topological change; apoptosis; positive regulation of apoptosis; positive regulation of caspase activity; base-excision repair, DNA ligation; negative regulation of transcription from RNA polymerase II promoter; DNA recombination; chromatin remodeling; regulation of transcription from RNA polymerase II promoter; myeloid dendritic cell activation; inflammatory response to antigenic stimulus; positive chemotaxis; innate immune response; DNA ligation during DNA repair; dendritic cell chemotaxis; positive regulation of transcription from RNA polymerase II promoter; DNA fragmentation during apoptosis; neurite development; positive regulation of DNA binding; cell structure disassembly during apoptosis
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 Research Articles on HMGB1    1. study provides first observations on the association of HMGB1 with psoriasis vulgaris (PV), and showed the elevated HMGB1 serum levels and altered HMGB1 distribution in lesional skin in patients
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to HMG1 (HMGB1, High Mobility Group, HMG Transcription Factor Box1, Amphoterin,
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 MBS2051038  FITC-Linked Polyclonal Antibody to High Mobility Group Protein 17 (HMG17)  MBS242377  Rabbit Polyclonal (IgG) to Pig HMG1 / HMGB1
 MBS9218925  HMG1L10 Antibody (N-term) Blocking peptide  MBS2007018  Polyclonal Antibody to High Mobility Group Protein 1 (HMG1)
Products associated with anti-HMGB1 antibodyPathways associated with anti-HMGB1 antibody
 Reference Product  PubMed Publications
 TNF antibody  >357 publications with HMGB1 and TNF
 TLR4 antibody  >256 publications with HMGB1 and TLR4
 TP53 antibody  >6 publications with HMGB1 and TP53
 DIF antibody  >2 publications with HMGB1 and DIF
 AGER antibody  >2 publications with HMGB1 and AGER
 PLAT antibody  >1 publications with HMGB1 and PLAT
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of DNA Fragmentation Factor Pathway antibodies  Activation Of DNA Fragmentation Factor Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Induced DNA Fragmentation Pathway antibodies  Apoptosis Induced DNA Fragmentation Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
Diseases associated with anti-HMGB1 antibodyOrgans/Tissues associated with anti-HMGB1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1036 publications with HMGB1 and Inflammation
 Necrosis Antibodies  >600 publications with HMGB1 and Necrosis
 Sepsis Antibodies  >418 publications with HMGB1 and Sepsis
 Neoplasms Antibodies  >398 publications with HMGB1 and Neoplasms
 Disease Models, Animal Antibodies  >296 publications with HMGB1 and Disease Models, Animal
 Lung Diseases Antibodies  >169 publications with HMGB1 and Lung Diseases
 Liver Diseases Antibodies  >123 publications with HMGB1 and Liver Diseases
 Heart Diseases Antibodies  >89 publications with HMGB1 and Heart Diseases
 Myocardial Ischemia Antibodies  >72 publications with HMGB1 and Myocardial Ischemia
 Atherosclerosis Antibodies  >67 publications with HMGB1 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >894 publications with HMGB1 and Blood
 Liver Antibodies  >320 publications with HMGB1 and Liver
 Lung Antibodies  >289 publications with HMGB1 and Lung
 Brain Antibodies  >232 publications with HMGB1 and Brain
 Vascular Antibodies  >231 publications with HMGB1 and Vascular
 Muscle Antibodies  >135 publications with HMGB1 and Muscle
 Heart Antibodies  >121 publications with HMGB1 and Heart
 Kidney Antibodies  >114 publications with HMGB1 and Kidney
 Bone Antibodies  >96 publications with HMGB1 and Bone
 Nerve Antibodies  >95 publications with HMGB1 and Nerve
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