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anti-HMGB1 antibody :: Rabbit HMGB1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS415947
Western Blot (WB)
Unit / Price
0.1 mL  /  $230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HMGB1, Polyclonal Antibody

 Also Known As   

Anti-HMGB1 Antibody

 Product Gene Name   

anti-HMGB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    163905
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat, Mouse
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 Purity/Purification    Affinity purified
 Form/Format    Liquid
 Concentration    100ug/100ul (lot specific)
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 Storage Buffer    PBS, pH 7.4 with 0.02% Sodium Azide
 Immunogen    Synthetic peptide conjugated to KLH
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 Preparation and Storage    This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
 Other Notes    Small volumes of anti-HMGB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HMGB1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-HMGB1 antibody    Peptide ELISA titer: 1:160,000
Western blot analysis: 1:200-1000
Optimal dilutions/concentrations should be determined by the end user.
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 Western Blot (WB) of anti-HMGB1 antibody    anti-HMGB1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for HMGB1. It may not necessarily be applicable to this product.
 NCBI GI #    118918424
 NCBI GeneID    3146
 NCBI Accession #    NP_002119.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002128 [Other Products]
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 UniProt Secondary Accession #    Q14321; Q5T7C3; Q6IBE1; A5D8W9 [Other Products]
 UniProt Related Accession #    P09429 [Other Products]
 Molecular Weight    24,894 Da
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 NCBI Official Full Name    Homo sapiens high mobility group box 1 (HMGB1), mRNA
 NCBI Official Synonym Full Names    high mobility group box 1
 NCBI Official Symbol    HMGB1 [Similar Products]
 NCBI Official Synonym Symbols   
HMG1; HMG3; SBP-1
[Similar Products]
 NCBI Protein Information    high mobility group protein B1; Amphoterin; HMG-1; Sulfoglucuronyl carbohydrate binding protein; high mobility group protein 1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1
 UniProt Protein Name    High mobility group protein B1
 UniProt Synonym Protein Names   
High mobility group protein 1; HMG-1
 Protein Family    High mobility group protein
 UniProt Gene Name    HMGB1 [Similar Products]
 UniProt Entry Name    HMGB1_HUMAN
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 UniProt Comments for HMGB1    HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Belongs to the HMGB family.

Protein type: DNA repair, damage; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 13q12

Cellular Component: nucleoplasm; extracellular space; cell surface; transcriptional repressor complex; extracellular region; condensed chromosome; nucleus

Molecular Function: RAGE receptor binding; protein binding; double-stranded DNA binding; cytokine activity; damaged DNA binding; chromatin binding; transcription factor activity; DNA bending activity; transcription factor binding; single-stranded DNA binding; chemoattractant activity

Biological Process: negative regulation of transcriptional preinitiation complex assembly; V(D)J recombination; DNA topological change; apoptosis; positive regulation of apoptosis; positive regulation of caspase activity; base-excision repair, DNA ligation; negative regulation of transcription from RNA polymerase II promoter; DNA recombination; regulation of transcription from RNA polymerase II promoter; chromatin remodeling; myeloid dendritic cell activation; inflammatory response to antigenic stimulus; positive chemotaxis; dendritic cell chemotaxis; innate immune response; DNA ligation during DNA repair; positive regulation of transcription from RNA polymerase II promoter; DNA fragmentation during apoptosis; neurite development; cell structure disassembly during apoptosis; positive regulation of DNA binding
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Product References and Citations for anti-HMGB1 antibody

   (1) Ge,H. and Roeder,R.G. The high mobility group protein HMG1 can reversibly inhibit class II gene transcription by interaction with the TATA-binding protein.J. Biol. Chem. 1994, 269 (25), 17136-17140
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 Research Articles on HMGB1    1. In blunt chest trauma, plasma HMGB1 levels were significantly higher in patients with post traumatic stress disorder compared with patients with non-PTSD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HMGB1 antibodyPathways associated with anti-HMGB1 antibody
 Reference Product  PubMed Publications
 TNF antibody  >467 publications with HMGB1 and TNF
 TLR4 antibody  >358 publications with HMGB1 and TLR4
 TP53 antibody  >8 publications with HMGB1 and TP53
 AGER antibody  >4 publications with HMGB1 and AGER
 DIF antibody  >2 publications with HMGB1 and DIF
 PLAT antibody  >1 publications with HMGB1 and PLAT
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of DNA Fragmentation Factor Pathway antibodies  Activation Of DNA Fragmentation Factor Pathway Diagram
 Advanced Glycosylation Endproduct Receptor Signaling Pathway antibodies  Advanced Glycosylation Endproduct Receptor Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Induced DNA Fragmentation Pathway antibodies  Apoptosis Induced DNA Fragmentation Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
Diseases associated with anti-HMGB1 antibodyOrgans/Tissues associated with anti-HMGB1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1359 publications with HMGB1 and Inflammation
 Necrosis Antibodies  >757 publications with HMGB1 and Necrosis
 Sepsis Antibodies  >497 publications with HMGB1 and Sepsis
 Cardiovascular Diseases Antibodies  >410 publications with HMGB1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >385 publications with HMGB1 and Disease Models, Animal
 Lung Diseases Antibodies  >226 publications with HMGB1 and Lung Diseases
 Liver Diseases Antibodies  >176 publications with HMGB1 and Liver Diseases
 Heart Diseases Antibodies  >128 publications with HMGB1 and Heart Diseases
 Myocardial Ischemia Antibodies  >107 publications with HMGB1 and Myocardial Ischemia
 Kidney Diseases Antibodies  >87 publications with HMGB1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1121 publications with HMGB1 and Blood
 Liver Antibodies  >417 publications with HMGB1 and Liver
 Lung Antibodies  >385 publications with HMGB1 and Lung
 Brain Antibodies  >315 publications with HMGB1 and Brain
 Vascular Antibodies  >296 publications with HMGB1 and Vascular
 Muscle Antibodies  >180 publications with HMGB1 and Muscle
 Heart Antibodies  >168 publications with HMGB1 and Heart
 Kidney Antibodies  >158 publications with HMGB1 and Kidney
 Bone Antibodies  >132 publications with HMGB1 and Bone
 Thymus Antibodies  >104 publications with HMGB1 and Thymus
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