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anti-HMGCR antibody :: Rabbit HMGCR Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127489
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HMGCR, Polyclonal Antibody

 Also Known As   

HMGCR Polyclonal Antibody

 Product Synonym Names    LDLCQ3
 Product Gene Name   

anti-HMGCR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    142910
 3D Structure    ModBase 3D Structure for P04035
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human HMGCR
 Calculated Molecular Weight    95kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-HMGCR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HMGCR antibody

   HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
 Product Categories/Family for anti-HMGCR antibody    Polyclonal
 Applications Tested/Suitable for anti-HMGCR antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-HMGCR antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-HMGCR antibody    Western blot analysis of extracts of various cell lines, using HMGCR antibody.
anti-HMGCR antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC of anti-HMGCR antibody    Immunohistochemistry of paraffin-embedded human kidney using HMGCR antibody at dilution of 1:200 (x400 lens).
anti-HMGCR antibody Immunohistochemistry (IHC (IHC) image
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 Immunofluorescence (IF) of anti-HMGCR antibody    Immunofluorescence analysis of A549 cell using HMGCR antibody. Blue: DAPI for nuclear staining.
anti-HMGCR antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for HMGCR. It may not necessarily be applicable to this product.
 NCBI GI #    123343
 NCBI GeneID    3156
 NCBI Accession #    P04035.1 [Other Products]
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 UniProt Primary Accession #    P04035 [Other Products]
 UniProt Secondary Accession #    Q8N190; B7Z3Y9 [Other Products]
 UniProt Related Accession #    P04035 [Other Products]
 Molecular Weight    888
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 NCBI Official Full Name    3-hydroxy-3-methylglutaryl-coenzyme A reductase
 NCBI Official Synonym Full Names    3-hydroxy-3-methylglutaryl-CoA reductase
 NCBI Official Symbol    HMGCR [Similar Products]
 NCBI Official Synonym Symbols   
LDLCQ3
[Similar Products]
 NCBI Protein Information    3-hydroxy-3-methylglutaryl-Coenzyme A reductase; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH)
 UniProt Protein Name    3-hydroxy-3-methylglutaryl-coenzyme A reductase
 UniProt Gene Name    HMGCR [Similar Products]
 UniProt Synonym Gene Names    HMG-CoA reductase [Similar Products]
 UniProt Entry Name    HMDH_HUMAN
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 NCBI Summary for HMGCR    HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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 UniProt Comments for HMGCR    HMGCR: the rate-limiting enzyme for cholesterol synthesis. Regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by this reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.

Protein type: EC 1.1.1.34; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis; Oxidoreductase; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q13.3-q14

Cellular Component: peroxisomal membrane; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane

Molecular Function: protein binding; hydroxymethylglutaryl-CoA reductase (NADPH) activity; protein homodimerization activity; hydroxymethylglutaryl-CoA reductase activity; coenzyme binding

Biological Process: negative regulation of MAP kinase activity; isoprenoid biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of skeletal muscle development; cellular lipid metabolic process; cholesterol biosynthetic process; positive regulation of stress-activated MAPK cascade; coenzyme A metabolic process; myoblast differentiation; ubiquinone metabolic process; response to ethanol; negative regulation of vasodilation; visual learning; protein tetramerization; response to nutrient; aging
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 Research Articles on HMGCR    1. HMGCR is differentially expressed in colorectal cancer and that positive expression is associated with favourable tumour characteristics and a prolonged survival in unadjusted analysis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HMGCR antibodyPathways associated with anti-HMGCR antibody
 Reference Product  PubMed Publications
 SREBF2 antibody  >26 publications with HMGCR and SREBF2
 HMGCS1 antibody  >17 publications with HMGCR and HMGCS1
 SQLE antibody  >8 publications with HMGCR and SQLE
 INSIG1 antibody  >5 publications with HMGCR and INSIG1
 MVK antibody  >4 publications with HMGCR and MVK
 SC4MOL antibody  >2 publications with HMGCR and SC4MOL
 PPARA antibody  >2 publications with HMGCR and PPARA
 HMGCS2 antibody  >2 publications with HMGCR and HMGCS2
 CREBBP antibody  >1 publications with HMGCR and CREBBP
 UBC antibody  >1 publications with HMGCR and UBC
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
Diseases associated with anti-HMGCR antibodyOrgans/Tissues associated with anti-HMGCR antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >61 publications with HMGCR and Cardiovascular Diseases
 Fatty Liver Antibodies  >49 publications with HMGCR and Fatty Liver
 Dyslipidemias Antibodies  >43 publications with HMGCR and Dyslipidemias
 Hypercholesterolemia Antibodies  >43 publications with HMGCR and Hypercholesterolemia
 Atherosclerosis Antibodies  >42 publications with HMGCR and Atherosclerosis
 Nervous System Diseases Antibodies  >40 publications with HMGCR and Nervous System Diseases
 Liver Diseases Antibodies  >37 publications with HMGCR and Liver Diseases
 Hyperlipidemias Antibodies  >36 publications with HMGCR and Hyperlipidemias
 Inflammation Antibodies  >27 publications with HMGCR and Inflammation
 Heart Diseases Antibodies  >25 publications with HMGCR and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >163 publications with HMGCR and Liver
 Blood Antibodies  >157 publications with HMGCR and Blood
 Heart Antibodies  >32 publications with HMGCR and Heart
 Muscle Antibodies  >32 publications with HMGCR and Muscle
 Brain Antibodies  >32 publications with HMGCR and Brain
 Kidney Antibodies  >25 publications with HMGCR and Kidney
 Vascular Antibodies  >23 publications with HMGCR and Vascular
 Ovary Antibodies  >16 publications with HMGCR and Ovary
 Intestine Antibodies  >11 publications with HMGCR and Intestine
 Nerve Antibodies  >9 publications with HMGCR and Nerve
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