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anti-HMGCS1 antibody :: Rabbit HMGCS1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7600163
Unit / Price
0.1 mg  /  $265 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HMGCS1, Polyclonal Antibody

★Popular Item★
 Also Known As   

HMGCS1 Rabbit Polyclonal

 Product Synonym Names    HMG CoA synthase, HMGCS, HMGCS1, 3-hydroxy-3-methylglutaryl coenzyme A synthase, Hydroxymethylglutaryl-CoA synthase, cytoplasmic
 Product Gene Name   

anti-HMGCS1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    142940
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Human, Mouse ,Rat; other speCIes are not tested. Please decide the specificity by homology
 Purity/Purification    >=95% as determined by SDS-PAGE
Immunogen Affinity Purified
 Form/Format    Liquid
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 Immunogen    3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
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 Preparation and Storage    PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HMGCS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HMGCS1 antibody

   HMGCSl(Hydroxymethylglutaryl-CoA synthase, cytoplasmic) is also named as HMGCS and belongs to the HMG-CoA synthase family. The gene encodes a 520 amino acid protein which catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA into 3-hydroxy-3-methylglutaryl CoA and participates in the mevalonate pathway but its end product is cholesterol(PMID:20346956). The human and hamster enzymes are distinguished by differential inhibition by magnesium ion(PMID:2870496).
 Applications Tested/Suitable for anti-HMGCS1 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

 Application Notes for anti-HMGCS1 antibody    WB: 1:1000-1:1OOOO
IP: 1:500-1:5000
IF: 1:10-1:100
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 Immunofluorescent of anti-HMGCS1 antibody    Immunofluorescent analysis of HepG2 cells, using HMGCSI antibody MBS7600163 at 1 :25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
anti-HMGCS1 antibody Immunofluorescent image
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 Immunoprecipitation of anti-HMGCS1 antibody    IP Result of anti-HMGCSI (IP: HMGCSI antibody, 3ug; Detection: HMGCS 1 antibody 1: 1000) with mouse liver tissue lysate 4000ug.
anti-HMGCS1 antibody Immunoprecipitation (IP) image
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 Western Blot of anti-HMGCS1 antibody    A431 cells were subjected to SDS PAGE followed by western blot with MBS7600163(HMGCS 1 antibody) at dilution of 1 :500
anti-HMGCS1 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for HMGCS1. It may not necessarily be applicable to this product.
 NCBI GI #    1023300945
 NCBI GeneID    3157
 NCBI Accession #    NP_001311152.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001324223.1 [Other Products]
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 UniProt Secondary Accession #    B2RDL8 [Other Products]
 UniProt Related Accession #    Q01581 [Other Products]
 Molecular Weight    57kDa
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 NCBI Official Full Name    hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2
 NCBI Official Synonym Full Names    3-hydroxy-3-methylglutaryl-CoA synthase 1
 NCBI Official Symbol    HMGCS1 [Similar Products]
 NCBI Official Synonym Symbols   
HMGCS
[Similar Products]
 NCBI Protein Information    hydroxymethylglutaryl-CoA synthase, cytoplasmic
 UniProt Protein Name    Hydroxymethylglutaryl-CoA synthase, cytoplasmic
 UniProt Synonym Protein Names   
3-hydroxy-3-methylglutaryl coenzyme A synthase
 Protein Family    Hydroxymethylglutaryl-CoA synthase
 UniProt Gene Name    HMGCS1 [Similar Products]
 UniProt Synonym Gene Names    HMGCS; HMG-CoA synthase [Similar Products]
 UniProt Entry Name    HMCS1_HUMAN
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 UniProt Comments for HMGCS1    HMGCS1: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the HMG-CoA synthase family.

Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase; EC 2.3.3.10; Lipid Metabolism - synthesis and degradation of ketone bodies; Carbohydrate Metabolism - butanoate

Chromosomal Location of Human Ortholog: 5p14-p13

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane

Molecular Function: drug binding; hydroxymethylglutaryl-CoA synthase activity; isomerase activity; organic acid binding; protein homodimerization activity

Biological Process: brain development; cholesterol biosynthetic process; isoprenoid biosynthetic process; lipid metabolic process; liver development; male gonad development; response to drug; response to lipoprotein stimulus; response to low light intensity; response to purine; response to tellurium ion; response to vitamin E
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 Research Articles on HMGCS1    1. The authors report high-resolution crystal structures of the human cytosolic (hHMGCS1) and mitochondrial (hHMGCS2) isoforms in binary product complexes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HMGCS1 antibodyDiseases associated with anti-HMGCS1 antibody
 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >8 publications with HMGCS1 and Liver Diseases
 Fatty Liver Antibodies  >8 publications with HMGCS1 and Fatty Liver
 Inflammation Antibodies  >5 publications with HMGCS1 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >4 publications with HMGCS1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >4 publications with HMGCS1 and Liver Neoplasms
 Hepatitis Antibodies  >4 publications with HMGCS1 and Hepatitis
 Cardiovascular Diseases Antibodies  >4 publications with HMGCS1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >4 publications with HMGCS1 and Disease Models, Animal
 Weight Loss Antibodies  >3 publications with HMGCS1 and Weight Loss
 Mental Disorders Antibodies  >3 publications with HMGCS1 and Mental Disorders
Organs/Tissues associated with anti-HMGCS1 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >23 publications with HMGCS1 and Liver
 Blood Antibodies  >13 publications with HMGCS1 and Blood
 Ovary Antibodies  >4 publications with HMGCS1 and Ovary
 Lung Antibodies  >3 publications with HMGCS1 and Lung
 Bone Antibodies  >3 publications with HMGCS1 and Bone
 Brain Antibodies  >3 publications with HMGCS1 and Brain
 Nerve Antibodies  >2 publications with HMGCS1 and Nerve
 Heart Antibodies  >2 publications with HMGCS1 and Heart
 Connective Tissue Antibodies  >2 publications with HMGCS1 and Connective Tissue
 Mammary Gland Antibodies  >1 publications with HMGCS1 and Mammary Gland
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