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anti-HMGCS2 antibody :: Rabbit anti-Human HMGCS2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS628162 anti-HMGCS2 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HMGCS2, Polyclonal Antibody

 Also Known As   

HMGCS2, CT (3-hydroxy-3-methylglutaryl Coenzyme A Synthase 2, Hydroxymethylglutaryl-CoA Synthase Mitochondrial, HMG-CoA Synthase)

 Product Synonym Names    Anti -HMGCS2, CT (3-hydroxy-3-methylglutaryl Coenzyme A Synthase 2, Hydroxymethylglutaryl-CoA Synthase Mitochondrial, HMG-CoA Synthase)
 Product Gene Name   

anti-HMGCS2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (120290619..120311555, complement). Location: 1p13-p12
 OMIM    600234
 3D Structure    ModBase 3D Structure for P54868
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human HMGCS2.
 Purity/Purification    Purified
Purified by ammonium sulfate precipitation.
 Form/Format    Supplied as a liquid in PBS, 0.35% sodium azide.
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 Immunogen    Synthetic peptide selected from the C-terminal region of human HMGCS2 (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-HMGCS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HMGCS2 antibody

   HMGCS2 belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting.
 Product Categories/Family for anti-HMGCS2 antibody    Antibodies; Abs to Coenzyme A
 Applications Tested/Suitable for anti-HMGCS2 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-HMGCS2 antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
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NCBI/Uniprot data below describe general gene information for HMGCS2. It may not necessarily be applicable to this product.
 NCBI GI #    260656028
 NCBI GeneID    3158
 NCBI Accession #    NP_001159579.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001166107.1 [Other Products]
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 UniProt Primary Accession #    P54868 [Other Products]
 UniProt Secondary Accession #    Q5SZU2; Q6IBF4; B7Z8R3; D3Y5K6 [Other Products]
 UniProt Related Accession #    P54868 [Other Products]
 Molecular Weight    56,635 Da [Similar Products]
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 NCBI Official Full Name    hydroxymethylglutaryl-CoA synthase, mitochondrial isoform 2
 NCBI Official Synonym Full Names    3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
 NCBI Official Symbol    HMGCS2 [Similar Products]
 NCBI Protein Information    hydroxymethylglutaryl-CoA synthase, mitochondrial; HMG-CoA synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)
 UniProt Protein Name    Hydroxymethylglutaryl-CoA synthase, mitochondrial
 UniProt Synonym Protein Names   
3-hydroxy-3-methylglutaryl coenzyme A synthase
 UniProt Gene Name    HMGCS2 [Similar Products]
 UniProt Synonym Gene Names    HMG-CoA synthase [Similar Products]
 UniProt Entry Name    HMCS2_HUMAN
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 NCBI Summary for HMGCS2    The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
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 UniProt Comments for HMGCS2    HMGCS2: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Defects in HMGCS2 are the cause of HMG-CoA synthase deficiency (HMGCS deficiency); also known as deficiency of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2. Affected individuals present with severe hypoketotic hypoglycemia, mild hepatomegaly, or fatty liver, and a nondiagnostic pattern of urinary organic acids with increase of medium and short chain dicarboxylic acids. Belongs to the HMG-CoA synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Carbohydrate Metabolism - butanoate; Transferase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Lipid Metabolism - synthesis and degradation of ketone bodies; Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 2.3.3.10

Chromosomal Location of Human Ortholog: 1p13-p12

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial inner membrane

Molecular Function: hydroxymethylglutaryl-CoA synthase activity

Biological Process: isoprenoid biosynthetic process; ketone body biosynthetic process; ketone body metabolic process; cellular lipid metabolic process; cholesterol biosynthetic process

Disease: 3-hydroxy-3-methylglutaryl-coa Synthase 2 Deficiency
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 Research Articles on HMGCS2    1. An alternative transcript of HMGCS2 carrying a deletion of exon 4, and two alternative transcripts of HMGCL with deletions of exons 5 and 6, and exons 5, 6 and 7, respectively, were detected.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HMGCS2 antibodyPathways associated with anti-HMGCS2 antibody
 Reference Product  PubMed Publications
 ACAT1 antibody  >5 publications with HMGCS2 and ACAT1
 HMGCL antibody  >4 publications with HMGCS2 and HMGCL
 PPARA antibody  >4 publications with HMGCS2 and PPARA
 MYC antibody  >2 publications with HMGCS2 and MYC
 ACAA2 antibody  >1 publications with HMGCS2 and ACAA2
 ACAT2 antibody  >1 publications with HMGCS2 and ACAT2
 Products by Pathway  Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Ketone Body Metabolism Pathway antibodies  Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
 PPAR Signaling Pathway antibodies  PPAR Signaling Pathway Diagram
Diseases associated with anti-HMGCS2 antibodyOrgans/Tissues associated with anti-HMGCS2 antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >13 publications with HMGCS2 and Fatty Liver
 Neoplasms Antibodies  >3 publications with HMGCS2 and Neoplasms
 Liver Diseases Antibodies  >2 publications with HMGCS2 and Liver Diseases
 Prenatal Exposure Delayed Effects Antibodies  >2 publications with HMGCS2 and Prenatal Exposure Delayed Effects
 Kidney Diseases Antibodies  >2 publications with HMGCS2 and Kidney Diseases
 Breast Neoplasms Antibodies  >2 publications with HMGCS2 and Breast Neoplasms
 Nervous System Diseases Antibodies  >2 publications with HMGCS2 and Nervous System Diseases
 Mitochondrial Diseases Antibodies  >2 publications with HMGCS2 and Mitochondrial Diseases
 Brain Diseases Antibodies  >2 publications with HMGCS2 and Brain Diseases
 Hypertension Antibodies  >2 publications with HMGCS2 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >24 publications with HMGCS2 and Liver
 Muscle Antibodies  >4 publications with HMGCS2 and Muscle
 Heart Antibodies  >3 publications with HMGCS2 and Heart
 Lung Antibodies  >3 publications with HMGCS2 and Lung
 Kidney Antibodies  >3 publications with HMGCS2 and Kidney
 Intestine Antibodies  >3 publications with HMGCS2 and Intestine
 Brain Antibodies  >2 publications with HMGCS2 and Brain
 Pancreas Antibodies  >1 publications with HMGCS2 and Pancreas
 Mammary Gland Antibodies  >1 publications with HMGCS2 and Mammary Gland
 Prostate Antibodies  >1 publications with HMGCS2 and Prostate
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