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anti-HMMR antibody :: Rabbit HMMR / CD168 / RHAMM Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS243539
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HMMR / CD168 / RHAMM, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human HMMR / CD168 / RHAMM

 Product Synonym Names    Anti-HMMR / CD168 / RHAMM Antibody (N-Terminus) IHC-plus; HMMR; CD168; CD168 antigen; RHAMM; IHABP; Human HMMR; CD168; RHAMM
 Product Gene Name   

anti-HMMR antibody

[Similar Products]
 Product Synonym Gene Name    CD168; RHAMM [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600936
 3D Structure    ModBase 3D Structure for O75330
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Human HMMR / RHAMM.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    A 18 amino acid peptide near the amino terminus of human RHAMM
 Immunogen Type    Synthetic peptide
 Antigen Modification    N-Terminus
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-HMMR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HMMR antibody

   The receptor for hyaluronan mediated motility has been reported to mediate migration, transformation, and metastatic spread of murine fibroblasts. In human, it is expressed as an intracellular protein in breast cancer cells. No correlation between the level of HMMR mRNA and protein expression with known metastatic/malignant potential of the tumor cell lines was observed.
 Applications Tested/Suitable for anti-HMMR antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-HMMR antibody    IHC-P (5 ug/ml), WB (0.5 - 1 ug/ml)
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 Immunohistochemistry (IHC) of anti-HMMR antibody    Anti-HMMR / RHAMM antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-HMMR antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-HMMR antibody    Immunofluorescence of RHAMM in human stomach tissue with RHAM antibody at 20 ug/ml.
anti-HMMR antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-HMMR antibody    Western blot analysis of RHAMM in rat stomach tissue lysate with RHAMM antibody at 1 ug/ml.
anti-HMMR antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for HMMR. It may not necessarily be applicable to this product.
 NCBI GI #    217416394
 NCBI GeneID    3161
 NCBI Accession #    NP_036616.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_012484.2 [Other Products]
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 UniProt Primary Accession #    O75330 [Other Products]
 UniProt Secondary Accession #    Q32N02; Q92767; A8K3G2; B4E114; D3DQK9; D3DQL0; E9PCS0 [Other Products]
 UniProt Related Accession #    O75330 [Other Products]
 Molecular Weight    74,495 Da
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 NCBI Official Full Name    hyaluronan mediated motility receptor isoform b
 NCBI Official Synonym Full Names    hyaluronan-mediated motility receptor (RHAMM)
 NCBI Official Symbol    HMMR [Similar Products]
 NCBI Official Synonym Symbols   
CD168; IHABP; RHAMM
[Similar Products]
 NCBI Protein Information    hyaluronan mediated motility receptor; receptor for hyaluronan-mediated motility; intracellular hyaluronic acid-binding protein
 UniProt Protein Name    Hyaluronan mediated motility receptor
 UniProt Synonym Protein Names   
Intracellular hyaluronic acid-binding protein; Receptor for hyaluronan-mediated motility; CD_antigen: CD168
 Protein Family    Hyaluronan mediated motility receptor
 UniProt Gene Name    HMMR [Similar Products]
 UniProt Synonym Gene Names    IHABP; RHAMM [Similar Products]
 UniProt Entry Name    HMMR_HUMAN
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 NCBI Summary for HMMR    The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]
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 UniProt Comments for HMMR    HMMR: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.

Chromosomal Location of Human Ortholog: 5q34

Cellular Component: cell surface; membrane; cytoplasm; plasma membrane

Molecular Function: hyaluronic acid binding

Biological Process: glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis; hyaluronan metabolic process; hyaluronan catabolic process

Disease: Breast Cancer
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 Research Articles on HMMR    1. stimulation of the E2F1-RHAMM axis in aggressive cancer cells is of high clinical significance
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HMMR antibodyPathways associated with anti-HMMR antibody
 Reference Product  PubMed Publications
 CD44 antibody  >22 publications with HMMR and CD44
 AURKA antibody  >4 publications with HMMR and AURKA
 DLGAP5 antibody  >3 publications with HMMR and DLGAP5
 CCNB1 antibody  >2 publications with HMMR and CCNB1
 TPX2 antibody  >2 publications with HMMR and TPX2
 ASPM antibody  >1 publications with HMMR and ASPM
 Products by Pathway  Pathway Diagram
 Defective B3GAT3 Causes JDSSDHD Pathway antibodies  Defective B3GAT3 Causes JDSSDHD Pathway Diagram
 Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway antibodies  Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway Diagram
 Defective B4GALT7 Causes EDS, Progeroid Type Pathway antibodies  Defective B4GALT7 Causes EDS, Progeroid Type Pathway Diagram
 Defective CHST14 Causes EDS, Musculocontractural Type Pathway antibodies  Defective CHST14 Causes EDS, Musculocontractural Type Pathway Diagram
 Defective CHST3 Causes SEDCJD Pathway antibodies  Defective CHST3 Causes SEDCJD Pathway Diagram
 Defective CHST6 Causes MCDC1 Pathway antibodies  Defective CHST6 Causes MCDC1 Pathway Diagram
 Defective CHSY1 Causes TPBS Pathway antibodies  Defective CHSY1 Causes TPBS Pathway Diagram
 Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway antibodies  Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway Diagram
 Defective EXT2 Causes Exostoses 2 Pathway antibodies  Defective EXT2 Causes Exostoses 2 Pathway Diagram
 Defective PAPSS2 Causes SEMD-PA Pathway antibodies  Defective PAPSS2 Causes SEMD-PA Pathway Diagram
Diseases associated with anti-HMMR antibodyOrgans/Tissues associated with anti-HMMR antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >10 publications with HMMR and Carcinoma
 Breast Neoplasms Antibodies  >9 publications with HMMR and Breast Neoplasms
 Adenocarcinoma Antibodies  >6 publications with HMMR and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >5 publications with HMMR and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >4 publications with HMMR and Nervous System Diseases
 Peripheral Nervous System Diseases Antibodies  >4 publications with HMMR and Peripheral Nervous System Diseases
 Disease Models, Animal Antibodies  >3 publications with HMMR and Disease Models, Animal
 Inflammation Antibodies  >2 publications with HMMR and Inflammation
 Carcinoma, Squamous Cell Antibodies  >2 publications with HMMR and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >2 publications with HMMR and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with HMMR and Blood
 Nerve Antibodies  >4 publications with HMMR and Nerve
 Prostate Antibodies  >4 publications with HMMR and Prostate
 Lung Antibodies  >4 publications with HMMR and Lung
 Bone Marrow Antibodies  >3 publications with HMMR and Bone Marrow
 Vascular Antibodies  >2 publications with HMMR and Vascular
 Skin Antibodies  >2 publications with HMMR and Skin
 Lymph Node Antibodies  >1 publications with HMMR and Lymph Node
 Salivary Gland Antibodies  >1 publications with HMMR and Salivary Gland
 Mouth Antibodies  >1 publications with HMMR and Mouth
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