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anti-HMOX2 antibody :: Goat HMOX2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422155
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HMOX2, Polyclonal Antibody

 Also Known As   

Goat anti-HMOX2 Antibody

 Product Synonym Names    HMOX2; heme oxygenase (decycling) 2; HO-2; heme oxygenase (decyclizing) 2; HMOX2 antibody; heme oxygenase (decycling) 2 antibody; HO-2 antibody; heme oxygenase (decyclizing) 2 antibody
 Product Gene Name   

anti-HMOX2 antibody

[Similar Products]
 Antibody/Peptide Pairs    HMOX2 peptide (MBS426969) is used for blocking the activity of HMOX2 antibody (MBS422155)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DQAGSTLARE TLED
 OMIM    141251
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DQAGSTLARETLED, from the internal region of the protein sequence according to NP_002125.3.
 Epitope    Internal region
 Note    Reported variants represent identical protein: NP_002125.3, NP_001120676.1, NP_001120678.1, NP_001120677.1
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-HMOX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HMOX2 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-HMOX2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Pancreas cancer shows increased staining of invading cancer cells. Recommended concentration, 2-4ug/ml.
Western Blot: Approx 37kDa band observed in lysates of cell line K562 (calculated MW of 36. 0kDa according to NP_002125.3). Recommended concentration: 0.3-1ug/ml.
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 Western Blot (WB) of anti-HMOX2 antibody    (0.3ug/ml) staining of K562 cell lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-HMOX2 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-HMOX2 antibody    (2ug/ml) staining of paraffin embedded Human Pancreas: cancer (left), adjacent to cancer (right). Steamed antigen retrieval with citrate buffer pH 6, Alexa594-staining.
anti-HMOX2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for HMOX2. It may not necessarily be applicable to this product.
 NCBI GI #    8051608
 NCBI GeneID    3163
 NCBI Accession #    NP_002125.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002134.3 [Other Products]
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 UniProt Secondary Accession #    O60605; A8MT35; D3DUD5; I3L430 [Other Products]
 UniProt Related Accession #    P30519 [Other Products]
 Molecular Weight    32,837 Da
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 NCBI Official Full Name    heme oxygenase 2 isoform b
 NCBI Official Synonym Full Names    heme oxygenase 2
 NCBI Official Symbol    HMOX2 [Similar Products]
 NCBI Official Synonym Symbols   
HO-2
[Similar Products]
 NCBI Protein Information    heme oxygenase 2
 UniProt Protein Name    Heme oxygenase 2
 UniProt Gene Name    HMOX2 [Similar Products]
 UniProt Synonym Gene Names    HO2; HO-2 [Similar Products]
 UniProt Entry Name    HMOX2_HUMAN
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 NCBI Summary for HMOX2    Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
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 UniProt Comments for HMOX2    HMOX2: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter. Belongs to the heme oxygenase family.

Protein type: Oxidoreductase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane

Molecular Function: heme oxygenase (decyclizing) activity; metal ion binding; protein binding

Biological Process: cellular iron ion homeostasis; heme catabolic process; heme oxidation; response to hypoxia
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 Research Articles on HMOX2    1. The same mechanism of heme hydroxylation to alpha-meso-hydroxyheme is employed by both isoforms HO-1 and HO-2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HMOX2 antibodyDiseases associated with anti-HMOX2 antibody
 Products by Pathway  Pathway Diagram
 Heme Degradation Pathway antibodies  Heme Degradation Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Porphyrins Pathway antibodies  Metabolism Of Porphyrins Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Porphyrin And Chlorophyll Metabolism Pathway antibodies  Porphyrin And Chlorophyll Metabolism Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Heme Degradation Pathway antibodies  Heme Degradation Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with HMOX2 and Nervous System Diseases
 Inflammation Antibodies  >2 publications with HMOX2 and Inflammation
 Necrosis Antibodies  >2 publications with HMOX2 and Necrosis
 Pain Antibodies  >1 publications with HMOX2 and Pain
 Cardiovascular Diseases Antibodies  >1 publications with HMOX2 and Cardiovascular Diseases
 Fatty Liver Antibodies  >1 publications with HMOX2 and Fatty Liver
 Hypertension Antibodies  >1 publications with HMOX2 and Hypertension
 Liver Diseases Antibodies  >1 publications with HMOX2 and Liver Diseases
Organs/Tissues associated with anti-HMOX2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with HMOX2 and Blood
 Liver Antibodies  >4 publications with HMOX2 and Liver
 Brain Antibodies  >3 publications with HMOX2 and Brain
 Muscle Antibodies  >2 publications with HMOX2 and Muscle
 Ear Antibodies  >1 publications with HMOX2 and Ear
 Eye Antibodies  >1 publications with HMOX2 and Eye
 Skin Antibodies  >1 publications with HMOX2 and Skin
 Testis Antibodies  >1 publications with HMOX2 and Testis
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