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anti-HNF1 alpha antibody :: Rabbit anti-Human HNF1 alpha Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS835587
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HNF1 alpha, Polyclonal Antibody

 Also Known As   

HNF1 alpha antibody

 Product Synonym Names    Polyclonal HNF1 alpha; Anti-HNF1 alpha; HNF-1-alpha; MODY3; HNF1A; HNF-1A; albumin proximal factor; TCF1; TCF-1; LFB1; IDDM20; HNF1
 Product Gene Name   

anti-HNF1 alpha antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    142330
 3D Structure    ModBase 3D Structure for P20823
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    HNF1 alpha antibody was purified by antigen-affinity chromatography
 Form/Format    Supplied as a concentrated soloution containing 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH 7.0). 0.01% Thimerosal was added as a preservative.
 Concentration    1 mg/ml (lot specific)
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 Biological Significance    The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 and also can result in the appearance of hepatic adenomas.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-HNF1 alpha antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HNF1 alpha antibody

   Affinity purified Rabbit polyclonal HNF1 alpha antibody
 Product Categories/Family for anti-HNF1 alpha antibody    DNA & RNA; Purified Polyclonal Antibodies
 Applications Tested/Suitable for anti-HNF1 alpha antibody   

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

 Application Notes for anti-HNF1 alpha antibody    IHC-P: 1:100-1:250
WB: 1:500-1:3000
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 Immunohistochemistry (IHC) of anti-HNF1 alpha antibody    Immunohistochemical staining of paraffin-embedded A549 Xenograft using HNF1 alpha antibody at a dilution of 1:100
anti-HNF1 alpha antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-HNF1 alpha antibody    Western blot analysis of 30 ug of whole cell lysate (A: Hep G2) using a 7.5 % SDS PAGE gel and HNF1 alpha antibody at a dilution of 1:1000
anti-HNF1 alpha antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for HNF1 alpha. It may not necessarily be applicable to this product.
 NCBI GI #    256542297
 NCBI GeneID    6927
 NCBI Accession #    NP_000536.5 [Other Products]
 NCBI GenBank Nucleotide #    NM_000545.5 [Other Products]
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 UniProt Primary Accession #    P20823 [Other Products]
 UniProt Secondary Accession #    Q2M3H2; Q99861; A5Z2R8; E0YMJ5; E0YMK0; E0YMK1; E2I9R4; E2I9R5; F5H5U3 [Other Products]
 UniProt Related Accession #    P20823 [Other Products]
 Molecular Weight    67 kDa
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 NCBI Official Full Name    hepatocyte nuclear factor 1-alpha isoform 2
 NCBI Official Synonym Full Names    HNF1 homeobox A
 NCBI Official Symbol    HNF1A [Similar Products]
 NCBI Official Synonym Symbols   
HNF1; LFB1; TCF1; MODY3; TCF-1; HNF-1A; IDDM20
[Similar Products]
 NCBI Protein Information    hepatocyte nuclear factor 1-alpha
 UniProt Protein Name    Hepatocyte nuclear factor 1-alpha
 UniProt Synonym Protein Names   
Liver-specific transcription factor LF-B1; LFB1; Transcription factor 1; TCF-1
 UniProt Gene Name    HNF1A [Similar Products]
 UniProt Synonym Gene Names    TCF1; HNF-1-alpha; HNF-1A; LFB1; TCF-1 [Similar Products]
 UniProt Entry Name    HNF1A_HUMAN
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 NCBI Summary for HNF1 alpha    The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
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 UniProt Comments for HNF1 alpha    HNF1A: Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. Defects in HNF1A are a cause of hepatic adenomas familial (HEPAF). Hepatic adenomas are rare benign liver tumors of presumable epithelial origin that develop in an otherwise normal liver. Hepatic adenomas may be single or multiple. They consist of sheets of well-differentiated hepatocytes that contain fat and glycogen and can produce bile. Bile ducts or portal areas are absent. Kupffer cells, if present, are reduced in number and are non-functional. Conditions associated with adenomas are insulin-dependent diabetes mellitus and glycogen storage diseases (types 1 and 3). Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas. Defects in HNF1A are the cause of maturity-onset diabetes of the young type 3 (MODY3); also symbolized MODY-3. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Defects in HNF1A are the cause of susceptibility to diabetes mellitus insulin-dependent type 20 (IDDM20). IDDM20 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These features can result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Belongs to the HNF1 homeobox family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: nucleoplasm; protein complex; cytoplasm; nucleus

Molecular Function: protein dimerization activity; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; insulin secretion; glucose import; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; glucose homeostasis

Disease: Diabetes Mellitus, Insulin-dependent, 20; Diabetes Mellitus, Insulin-dependent; Hepatic Adenomas, Familial; Maturity-onset Diabetes Of The Young, Type 3; Renal Cell Carcinoma, Nonpapillary; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on HNF1 alpha    1. Low prevalence of HNF1A mutations in italian families in diabetes clinic.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HNF1 alpha antibodyPathways associated with anti-HNF1 alpha antibody
 Reference Product  PubMed Publications
 HNF4A antibody  >189 publications with HNF1 alpha and HNF4A
 CTNNB1 antibody  >109 publications with HNF1 alpha and CTNNB1
 PDX1 antibody  >16 publications with HNF1 alpha and PDX1
 ONECUT1 antibody  >14 publications with HNF1 alpha and ONECUT1
 SLC2A2 antibody  >9 publications with HNF1 alpha and SLC2A2
 HNF4G antibody  >7 publications with HNF1 alpha and HNF4G
 CREBBP antibody  >4 publications with HNF1 alpha and CREBBP
 PCBD1 antibody  >1 publications with HNF1 alpha and PCBD1
 HDAC1 antibody  >1 publications with HNF1 alpha and HDAC1
 DYRK1B antibody  >1 publications with HNF1 alpha and DYRK1B
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Diseases associated with anti-HNF1 alpha antibodyOrgans/Tissues associated with anti-HNF1 alpha antibody
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >420 publications with HNF1 alpha and Diabetes Mellitus, Type 2
 Liver Diseases Antibodies  >198 publications with HNF1 alpha and Liver Diseases
 Liver Neoplasms Antibodies  >153 publications with HNF1 alpha and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >91 publications with HNF1 alpha and Carcinoma, Hepatocellular
 Diabetes Mellitus, Type 1 Antibodies  >81 publications with HNF1 alpha and Diabetes Mellitus, Type 1
 Disease Models, Animal Antibodies  >65 publications with HNF1 alpha and Disease Models, Animal
 Inflammation Antibodies  >60 publications with HNF1 alpha and Inflammation
 Neoplasms, Experimental Antibodies  >44 publications with HNF1 alpha and Neoplasms, Experimental
 Adenoma, Liver Cell Antibodies  >43 publications with HNF1 alpha and Adenoma, Liver Cell
 Kidney Diseases Antibodies  >39 publications with HNF1 alpha and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >548 publications with HNF1 alpha and Liver
 Kidney Antibodies  >125 publications with HNF1 alpha and Kidney
 Intestine Antibodies  >88 publications with HNF1 alpha and Intestine
 Stomach Antibodies  >11 publications with HNF1 alpha and Stomach
 Mixed Antibodies  >6 publications with HNF1 alpha and Mixed
 Eye Antibodies  >6 publications with HNF1 alpha and Eye
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