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anti-HNF4A antibody :: Rabbit HNF4A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2525846
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HNF4A, Polyclonal Antibody

 Also Known As   

HNF4A Antibody

 Product Synonym Names    HNF4A; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14
 Product Gene Name   

anti-HNF4A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    125850
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1mg/mL (lot specific)
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 Immunogen    A synthetic peptide of human HNF4A
 Observed Molecular Weight: 52kDa   
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6556 / sc-6557 / sc-8987
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-HNF4A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HNF4A antibody

   Hepatocyte nuclear factor 4alpha (HNF4alpha) is a transcription factor that belongs to the steroid hormone receptor superfamily and is enriched in liver (1). HNF4alpha, in association with PGC-1alpha, activates gluconeogenic genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase genes in fasted livers (2, 3). Conditional knockout of the HNF4alpha gene in the mouse liver destroys lipid homeostasis and leads to lipid accumulation in the liver and a reduction of serum cholesterol and triglyceride levels (4). Mutations in HNF4alpha have been linked to maturity-onset diabetes of the young (MODY) (5).
 Applications Tested/Suitable for anti-HNF4A antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Western Blot (WB) of anti-HNF4A antibody    Western blot analysis of extracts of various cell lines, using HNF4A antibody.
anti-HNF4A antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-HNF4A antibody    Immunofluorescence analysis of A549 cell using HNF4A antibody. Blue: DAPI for nuclear staining.
anti-HNF4A antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for HNF4A. It may not necessarily be applicable to this product.
 NCBI GI #    563407072
 NCBI GeneID    3172
 NCBI Accession #    NP_001274112.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001287183.1 [Other Products]
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 UniProt Secondary Accession #    O00659; O00723; Q14540; Q5QPB8; Q6B4V5; Q6B4V6; Q6B4V7; Q92653; Q92654; A5JW41; B2RPP8 [Other Products]
 UniProt Related Accession #    P41235 [Other Products]
 Molecular Weight    43,988 Da
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 NCBI Official Full Name    hepatocyte nuclear factor 4-alpha isoform HNF4alpha11
 NCBI Official Synonym Full Names    hepatocyte nuclear factor 4, alpha
 NCBI Official Symbol    HNF4A [Similar Products]
 NCBI Official Synonym Symbols   
TCF; HNF4; MODY; FRTS4; MODY1; NR2A1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; HNF4alpha
[Similar Products]
 NCBI Protein Information    hepatocyte nuclear factor 4-alpha; HNF4alpha10/11/12; TCF-14; hepatic nuclear factor 4 alpha; nuclear receptor subfamily 2 group A member 1; transcription factor 14; transcription factor HNF-4
 UniProt Protein Name    Hepatocyte nuclear factor 4-alpha
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4
 Protein Family    Hepatocyte nuclear factor
 UniProt Gene Name    HNF4A [Similar Products]
 UniProt Synonym Gene Names    HNF4; NR2A1; TCF14; HNF-4-alpha; TCF-14 [Similar Products]
 UniProt Entry Name    HNF4A_HUMAN
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 NCBI Summary for HNF4A    The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
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 UniProt Comments for HNF4A    HNF4 alpha: a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described.

Protein type: Transcription factor; DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; DNA binding; zinc ion binding; steroid hormone receptor activity; fatty acid binding; transcription factor activity; receptor binding

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of lipid metabolic process; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; lipid homeostasis; glucose homeostasis; endocrine pancreas development; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; regulation of gastrulation; xenobiotic metabolic process; response to glucose stimulus; ornithine metabolic process; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of cell growth; lipid metabolic process; blood coagulation; regulation of insulin secretion; sex differentiation; phospholipid homeostasis

Disease: Fanconi Renotubular Syndrome 4 With Maturity-onset Diabetes Of The Young; Maturity-onset Diabetes Of The Young, Type 1; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on HNF4A    1. Data suggest that HNF4A is involved in regulation of both cellular response to endoplasmic reticulum stress and cell function (glucose-stimulated insulin secretion) in pancreatic beta cells. [REVIEW]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HNF4A antibodyDiseases associated with anti-HNF4A antibody
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >203 publications with HNF4A and Diabetes Mellitus, Type 2
 Liver Diseases Antibodies  >91 publications with HNF4A and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >50 publications with HNF4A and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >50 publications with HNF4A and Liver Neoplasms
 Fatty Liver Antibodies  >39 publications with HNF4A and Fatty Liver
 Hyperglycemia Antibodies  >36 publications with HNF4A and Hyperglycemia
 Insulin Resistance Antibodies  >26 publications with HNF4A and Insulin Resistance
 Inflammation Antibodies  >24 publications with HNF4A and Inflammation
 Cardiovascular Diseases Antibodies  >17 publications with HNF4A and Cardiovascular Diseases
 Hepatitis Antibodies  >17 publications with HNF4A and Hepatitis
Organs/Tissues associated with anti-HNF4A antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >338 publications with HNF4A and Liver
 Kidney Antibodies  >44 publications with HNF4A and Kidney
 Intestine Antibodies  >41 publications with HNF4A and Intestine
 Stomach Antibodies  >11 publications with HNF4A and Stomach
 Lung Antibodies  >6 publications with HNF4A and Lung
 Placenta Antibodies  >4 publications with HNF4A and Placenta
 Mammary Gland Antibodies  >1 publications with HNF4A and Mammary Gland
 Uncharacterized Tissue Antibodies  >1 publications with HNF4A and Uncharacterized Tissue
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