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anti-HNRNPL antibody :: Rabbit anti-Human HNRNPL Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1491998
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HNRNPL, Polyclonal Antibody

★Popular Item★
 Also Known As   

HNRNPL Antibody

 Product Synonym Names    Heterogeneous nuclear ribonucleoprotein L; hnRNP L; HNRNPL; HNRPL; P/OKcl.14
 Product Gene Name   

anti-HNRNPL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164021
 3D Structure    ModBase 3D Structure for P14866
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Heterogeneous nuclear ribonucleoprotein L protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16550 / sc-30720 / sc-28726
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HNRNPL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HNRNPL antibody

   Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.
 Applications Tested/Suitable for anti-HNRNPL antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-HNRNPL antibody    Recommended dilution: IHC:1:20-1:200
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 Western Blot (WB) of anti-HNRNPL antibody    Western Blot
Positive WB detected in:HepG2 whole cell lysate,Mouse heart tissue,Mouse brain tissue,Mouse kidney tissue
All lanes: HNRNPL antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 65,51 kDa
Observed band size: 65 kDa

anti-HNRNPL antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HNRNPL antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS1491998 at dilution of 1:100
anti-HNRNPL antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HNRNPL. It may not necessarily be applicable to this product.
 NCBI GI #    52632385
 NCBI GeneID    3191
 NCBI Accession #    NP_001005335.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001005335.1 [Other Products]
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 UniProt Primary Accession #    P14866 [Other Products]
 UniProt Secondary Accession #    Q9H3P3; A6ND69; A6NIT8 [Other Products]
 UniProt Related Accession #    P14866 [Other Products]
 Molecular Weight    50,561 Da
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 NCBI Official Full Name    heterogeneous nuclear ribonucleoprotein L isoform b
 NCBI Official Synonym Full Names    heterogeneous nuclear ribonucleoprotein L
 NCBI Official Symbol    HNRNPL [Similar Products]
 NCBI Official Synonym Symbols   
HNRPL; hnRNP-L; P/OKcl.14
[Similar Products]
 NCBI Protein Information    heterogeneous nuclear ribonucleoprotein L
 UniProt Protein Name    Heterogeneous nuclear ribonucleoprotein L
 Protein Family    Heterogeneous nuclear ribonucleoprotein
 UniProt Gene Name    HNRNPL [Similar Products]
 UniProt Synonym Gene Names    HNRPL; hnRNP L [Similar Products]
 UniProt Entry Name    HNRPL_HUMAN
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 NCBI Summary for HNRNPL    Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HNRNPL    hnRNP L: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Is associated with most nascent transcripts including those of the landmark giant loops of amphibian lampbrush chromosomes. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus; ribonucleoprotein complex

Molecular Function: nucleotide binding; protein binding; RNA binding

Biological Process: gene expression; nuclear mRNA splicing, via spliceosome; RNA processing; RNA splicing
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 Research Articles on HNRNPL    1. The study presents the structural characterization of the RNA recognition motif domains of hnRNP-L and demonstrate their function in repressing exon 4 of SLC2A2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HNRNPL antibodyPathways associated with anti-HNRNPL antibody
 Reference Product  PubMed Publications
 HNRNPK antibody  >2 publications with HNRNPL and HNRNPK
 HNRNPA3 antibody  >2 publications with HNRNPL and HNRNPA3
 HNRNPA2B1 antibody  >2 publications with HNRNPL and HNRNPA2B1
 HNRNPD antibody  >1 publications with HNRNPL and HNRNPD
 HNRNPA1 antibody  >1 publications with HNRNPL and HNRNPA1
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Processing Of Capped Intron-Containing Pre-mRNA Pathway antibodies  Processing Of Capped Intron-Containing Pre-mRNA Pathway Diagram
 MRNA Splicing Pathway antibodies  MRNA Splicing Pathway Diagram
 MRNA Splicing - Major Pathway antibodies  MRNA Splicing - Major Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram
Diseases associated with anti-HNRNPL antibodyOrgans/Tissues associated with anti-HNRNPL antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >3 publications with HNRNPL and Brain Diseases
 Nervous System Diseases Antibodies  >3 publications with HNRNPL and Nervous System Diseases
 Necrosis Antibodies  >2 publications with HNRNPL and Necrosis
 Ataxia Antibodies  >1 publications with HNRNPL and Ataxia
 Breast Neoplasms Antibodies  >1 publications with HNRNPL and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Thymus Antibodies  >2 publications with HNRNPL and Thymus
 Brain Antibodies  >2 publications with HNRNPL and Brain
 Vascular Antibodies  >1 publications with HNRNPL and Vascular
 Lymph Antibodies  >1 publications with HNRNPL and Lymph
 Lymph Node Antibodies  >1 publications with HNRNPL and Lymph Node
 Blood Antibodies  >1 publications with HNRNPL and Blood
 Lung Antibodies  >1 publications with HNRNPL and Lung
 Embryonic Tissue Antibodies  >1 publications with HNRNPL and Embryonic Tissue
 Testis Antibodies  >1 publications with HNRNPL and Testis
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