Q9Y5N1.2
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,607 Da
NCBI Official Full Name
Histamine H3 receptor
NCBI Official Synonym Full Names
histamine receptor H3
NCBI Official Synonym Symbols
NCBI Protein Information
histamine H3 receptor; G protein-coupled receptor 97; G-protein coupled receptor 97; H3R
UniProt Protein Name
Histamine H3 receptor
UniProt Synonym Protein Names
G-protein coupled receptor 97
UniProt Synonym Gene Names
UniProt Entry Name
HRH3_HUMAN
NCBI Summary for HRH3
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
UniProt Comments for HRH3
H3R: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization. Belongs to the G-protein coupled receptor 1 family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: 20q13.33
Cellular Component: neuron projection; integral to plasma membrane; plasma membrane; myelin sheath
Molecular Function: drug binding; histamine receptor activity
Biological Process: negative regulation of glutamate secretion; eating behavior; neurotransmitter secretion; drinking behavior; negative regulation of gamma-aminobutyric acid secretion; negative regulation of adenylate cyclase activity; learning; regulation of norepinephrine secretion; response to organic cyclic substance; memory; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of serotonin secretion; elevation of cytosolic calcium ion concentration; brain development; negative regulation of blood pressure; positive regulation of epithelial cell proliferation
Research Articles on HRH3
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Pathways associated with anti-HRH3 antibody
Diseases associated with anti-HRH3 antibody
Organs/Tissues associated with anti-HRH3 antibody
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