Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow HGS rightarrow Polyclonal HGS  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • neurocan (NCAN) ELISA Kit
 • ERalpha ELISA Kit
 • Beta-crystallin B2 (CRYBB2) Recombinant Protein
 • IgG (H&L) (FCGR1A) Secondary Antibody
 • IgG3, Kappa Immunoglobulin
 • CD92 Antibody
 • Aspartic proteinase nepenthesin-1 Recombinant Protein
 • C1QTNF3 ELISA Kit
 • HMGA1 cDNA Clone
 • Factor X Antibody
 • Smad7-MADH7 ELISA Kit
 • Hemoglobin H (HBH) ELISA Kit
 • EGFL7 Antibody
 • tachykinin 4 (hemokinin) (TAC4) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-HGS antibody :: Goat HRS/HGS Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420850
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HRS/HGS, Polyclonal Antibody

 Also Known As   

Goat anti-HRS/HGS Antibody

 Product Synonym Names    HGS; hepatocyte growth factor-regulated tyrosine kinase substrate; HGNC: 4897; HRS; ZFYVE8; human growth factor-regulated tyrosine kinase substrate; HGS antibody; hepatocyte growth factor-regulated tyrosine kinase substrate antibody; HGNC: 4897 antibody; HRS antibody; ZFYVE8 antibody; human growth factor-regulated tyrosine kinase substrate antibody; HRS / HGS
 Product Gene Name   

anti-HGS antibody

[Similar Products]
 Product Synonym Gene Name    HRS [Similar Products]
 Antibody/Peptide Pairs    HRS / HGS peptide (MBS425584) is used for blocking the activity of HRS/HGS antibody (MBS420850)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Immunogen Sequence    NRNYWEKKQE EARK
 OMIM    604375
Section Bar
 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
Section Bar
 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
Section Bar
 Immunogen    Peptide with sequence C-NRNYWEKKQEEARK, from the internal region of the protein sequence according to NP_004703.1.
 Epitope    Internal region
Section Bar
 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-HGS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-HGS antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-HGS antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Testis shows strong staining of Leydig cells. Recommended concentration, 1-2ug/ml.
Western Blot: Preliminary experiments gave bands at approx 140kDa and 26kDa in Human lysates of monocytic leukemia cell line U937 after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 86.2kDa according to NP_004703.1. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
Section Bar
 Immunohistochemistry (IHC) of anti-HGS antibody    (2.5ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-HGS antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for HGS. It may not necessarily be applicable to this product.
 NCBI GI #    4758528
 NCBI GeneID    9146
 NCBI Accession #    NP_004703.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004712.4 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q9NR36 [Other Products]
 UniProt Related Accession #    O14964 [Other Products]
 Molecular Weight    76,376 Da
Table BarTOPTable Bar
 NCBI Official Full Name    hepatocyte growth factor-regulated tyrosine kinase substrate
 NCBI Official Synonym Full Names    hepatocyte growth factor-regulated tyrosine kinase substrate
 NCBI Official Symbol    HGS [Similar Products]
 NCBI Official Synonym Symbols   
HRS
[Similar Products]
 NCBI Protein Information    hepatocyte growth factor-regulated tyrosine kinase substrate
 UniProt Protein Name    Hepatocyte growth factor-regulated tyrosine kinase substrate
 UniProt Synonym Protein Names   
Hrs
 Protein Family    Hepatocyte growth factor-regulated tyrosine kinase substrate
 UniProt Gene Name    HGS [Similar Products]
 UniProt Synonym Gene Names    HRS [Similar Products]
 UniProt Entry Name    HGS_HUMAN
Section Bar
 NCBI Summary for HGS    The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]
Section Bar
 UniProt Comments for HGS    Hrs: a zinc finger protein which is rapidly tyrosine phosphorylated in cells stimulated with various growth factors. Hrs mRNA is expressed in all the human adult and fetal tissues tested.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: cytoplasm; cytosol; early endosome; early endosome membrane; endosome; intracellular membrane-bound organelle

Molecular Function: metal ion binding; protein binding; protein domain specific binding

Biological Process: autophagy; endosome transport; membrane invagination; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of JAK-STAT cascade; protein targeting to lysosome; regulation of MAP kinase activity; regulation of protein catabolic process; signal transduction
Table BarTOPTable Bar
 Research Articles on HGS    1. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-HGS antibodyPathways associated with anti-HGS antibody
 Reference Product  PubMed Publications
 EGFR antibody  >6 publications with HGS and EGFR
 TSG101 antibody  >4 publications with HGS and TSG101
 EPS15 antibody  >1 publications with HGS and EPS15
 STAM2 antibody  >1 publications with HGS and STAM2
 UBC antibody  >1 publications with HGS and UBC
 Products by Pathway  Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 EGFR Downregulation Pathway antibodies  EGFR Downregulation Pathway Diagram
 ESCRT-0 Complex Pathway antibodies  ESCRT-0 Complex Pathway Diagram
 ESCRT-0 Complex Pathway antibodies  ESCRT-0 Complex Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endosomal Sorting Complex Required For Transport (ESCRT) Pathway antibodies  Endosomal Sorting Complex Required For Transport (ESCRT) Pathway Diagram
 Internalization Of ErbB1 Pathway antibodies  Internalization Of ErbB1 Pathway Diagram
 Lysosome Vesicle Biogenesis Pathway antibodies  Lysosome Vesicle Biogenesis Pathway Diagram
Diseases associated with anti-HGS antibodyOrgans/Tissues associated with anti-HGS antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >37 publications with HGS and Nervous System Diseases
 Necrosis Antibodies  >33 publications with HGS and Necrosis
 Liver Diseases Antibodies  >27 publications with HGS and Liver Diseases
 Inflammation Antibodies  >26 publications with HGS and Inflammation
 Kidney Diseases Antibodies  >25 publications with HGS and Kidney Diseases
 Cardiovascular Diseases Antibodies  >24 publications with HGS and Cardiovascular Diseases
 Renal Insufficiency Antibodies  >15 publications with HGS and Renal Insufficiency
 Weight Loss Antibodies  >14 publications with HGS and Weight Loss
 Hypertension Antibodies  >14 publications with HGS and Hypertension
 Brain Diseases Antibodies  >12 publications with HGS and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >114 publications with HGS and Muscle
 Blood Antibodies  >109 publications with HGS and Blood
 Brain Antibodies  >56 publications with HGS and Brain
 Kidney Antibodies  >42 publications with HGS and Kidney
 Liver Antibodies  >42 publications with HGS and Liver
 Bone Antibodies  >34 publications with HGS and Bone
 Lung Antibodies  >19 publications with HGS and Lung
 Heart Antibodies  >18 publications with HGS and Heart
 Nerve Antibodies  >18 publications with HGS and Nerve
 Skin Antibodies  >14 publications with HGS and Skin
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions