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anti-HSBP1 antibody :: Rabbit anti-Human HSBP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS858043
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HSBP1, Polyclonal Antibody

 Also Known As   

HSBP1 Antibody

 Product Gene Name   

anti-HSBP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604553
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Lyophilized HSBP1 antibody purified by protein affinity column containing 1% BSA and 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal HSBP1 (1) antibody was raised against a recombinate human HSBP1 protein 1-76aa (BC007515).
 Reactivity Note    Predicted: Mouse, Rat; Not yet tested in other species.
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 Preparation and Storage    Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
 Other Notes    Small volumes of anti-HSBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-HSBP1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-HSBP1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-HSBP1 antibody    ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.
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 Testing Data of anti-HSBP1 antibody    anti-HSBP1 antibody Testing Data image
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 Testing Data #2 of anti-HSBP1 antibody    anti-HSBP1 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for HSBP1. It may not necessarily be applicable to this product.
 NCBI GI #    38197090
 NCBI GeneID    3281
 NCBI Accession #    BC007515 [Other Products]
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 UniProt Secondary Accession #    Q53XA8; Q7Z5Z3 [Other Products]
 UniProt Related Accession #    O75506 [Other Products]
 Molecular Weight    8,544 Da
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 NCBI Official Full Name    Homo sapiens heat shock factor binding protein 1, mRNA
 NCBI Official Synonym Full Names    heat shock factor binding protein 1
 NCBI Official Symbol    HSBP1 [Similar Products]
 NCBI Official Synonym Symbols   
NPC-A-13
[Similar Products]
 NCBI Protein Information    heat shock factor-binding protein 1; nasopharyngeal carcinoma-associated antigen 13
 UniProt Protein Name    Heat shock factor-binding protein 1
 UniProt Synonym Protein Names   
Nasopharyngeal carcinoma-associated antigen 13; NPC-A-13
 Protein Family    Heat shock factor-binding protein
 UniProt Gene Name    HSBP1 [Similar Products]
 UniProt Synonym Gene Names    HSF1BP; NPC-A-13 [Similar Products]
 UniProt Entry Name    HSBP1_HUMAN
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 NCBI Summary for HSBP1    The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HSBP1    HSBP1: Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process. Belongs to the HSBP1 family.

Chromosomal Location of Human Ortholog: 16q23.3

Cellular Component: nucleoplasm; cytoskeleton; nucleus

Molecular Function: transcription corepressor activity

Biological Process: muscle contraction; negative regulation of transcription from RNA polymerase II promoter
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 Research Articles on HSBP1    1. HspBP1 inhibited the cytotoxic activity of the Tag7-Hsp70 complex secreted by lymphocytes. HspBP1
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HSBP1 antibodyPathways associated with anti-HSBP1 antibody
 Reference Product  PubMed Publications
 HSF1 antibody  >12 publications with HSBP1 and HSF1
 HSPA1A antibody  >2 publications with HSBP1 and HSPA1A
 HSPA4 antibody  >1 publications with HSBP1 and HSPA4
 Products by Pathway  Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 HSF1 Activation Pathway antibodies  HSF1 Activation Pathway Diagram
 HSF1-dependent Transactivation Pathway antibodies  HSF1-dependent Transactivation Pathway Diagram
Diseases associated with anti-HSBP1 antibodyOrgans/Tissues associated with anti-HSBP1 antibody
 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >3 publications with HSBP1 and Neurodegenerative Diseases
 Lung Neoplasms Antibodies  >1 publications with HSBP1 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with HSBP1 and Neoplasm Metastasis
 Neurobehavioral Manifestations Antibodies  >1 publications with HSBP1 and Neurobehavioral Manifestations
 Abnormalities, Drug-Induced Antibodies  >1 publications with HSBP1 and Abnormalities, Drug-Induced
 Disease Models, Animal Antibodies  >1 publications with HSBP1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with HSBP1 and Brain
 Muscle Antibodies  >2 publications with HSBP1 and Muscle
 Embryonic Tissue Antibodies  >2 publications with HSBP1 and Embryonic Tissue
 Blood Antibodies  >2 publications with HSBP1 and Blood
 Cervix Antibodies  >1 publications with HSBP1 and Cervix
 Vascular Antibodies  >1 publications with HSBP1 and Vascular
 Skin Antibodies  >1 publications with HSBP1 and Skin
 Liver Antibodies  >1 publications with HSBP1 and Liver
 Kidney Antibodies  >1 publications with HSBP1 and Kidney
 Lymph Antibodies  >1 publications with HSBP1 and Lymph
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