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anti-HSD17B1 antibody :: Rabbit HSD17B1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS177074
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HSD17B1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-HSD17B1 antibody

 Product Synonym Names    Estradiol 17-beta-dehydrogenase 1; hydroxysteroid(17-beta) dehydrogenase 1; 17 beta HSD 1 antibody; 17 beta hydroxysteroid dehydrogenase type 1 antibody; 17-beta-HSD 1 antibody; 17-beta-hydroxysteroid dehydrogenase type 1 antibody; 20 alpha-hydroxysteroid dehydrogenase antibody; 20-alpha-HSD antibody; DHB1_HUMAN antibody; E17KSR antibody; E2DH antibody; EDH17B1 antibody; EDH17B2 antibody; EDHB17 antibody; Estradiol 17 beta dehydrogenase 1 antibody; Estradiol 17-beta-dehydrogenase 1 antibody; HSD17 antibody; HSD17B1 antibody; Hydroxysteroid(17 beta) dehydrogenase 1 antibody; MGC13814 antibody; Placental 17 beta hydroxysteroid dehydrogenase antibody; Placental 17-beta-hydroxysteroid dehydrogenase antibody; SDR28C1 antibody; Short chain dehydrogenase/reductase family 28CE,member 1 antibody
 Product Gene Name   

anti-HSD17B1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109684
 3D Structure    ModBase 3D Structure for P14061
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Reacts with: Human, Rat
Predicted Species: Mouse
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 Specificity    No Cross reactivity with other proteins.
 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human HSD17B1 (29-43aa QSFKVYATLRDLKTQ), different from the related rat and mouse sequences by one amino acid.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HSD17B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HSD17B1 antibody

   Description: Rabbit IgG polyclonal antibody for Estradiol 17-beta-dehydrogenase 1(HSD17B1) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.
Background: HSD17B1(17-BETA-HYDROXYSTEROID DEHYDROGENASE I), also known as 17-beta-hydroxysteroid dehydrogenase or 17-ketosteroid reductase, is an enzyme that is responsible for the interconversion of estrone(E1) and estradiol(E2) as well as the interconversion of androstenedione and testosterone. Its cytogenetic location is 17q21.2. HSD17B1 gene expression is detected in 34 of 42(81%) adenomas in all tumor subtypes; HSD17B2 mRNA is detected in 18 of 42(43%) adenomas but not in prolactinomas. Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies. All 4 HSD17B isoforms are variably expressed in human anterior pituitary adenomas, which also show HSD17B enzyme activity, suggesting that HSD17B may play an important role in regulating the local cellular levels of estradiol.
 Applications Tested/Suitable for anti-HSD17B1 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

 Application Notes for anti-HSD17B1 antibody    Western Blot:
Concentration: 0.1-0.5ug/ml
Tested Species: Hu, Rat
Predicted Species: Ms

Immunohistochemistry (Paraffin-embedded Section):
Concentration: 0.5-1ug/ml
Tested Species: Hu, Rat
Predicted Species: Ms
Antigen Retrieval: By Heat

Immunocytochemistry:
Concentration: 0.5-1ug/ml
Tested Species: Hu
Predicted Species: Rat, Ms

Tested Species: In-house tested species with positive results.
Predicted Species: Species predicted to be fit for the product based on sequence similarities.
By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
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 Immunocytochemistry (ICC) of anti-HSD17B1 antibody    Anti-HSD17B1 antibody, MBS177074, ICC
ICC: HELA Cell
anti-HSD17B1 antibody Immunocytochemistry (ICC) (ICC) image
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 Western Blot (WB) of anti-HSD17B1 antibody    Anti-HSD17B1 antibody, MBS177074, Western blotting
Lane 1: Rat Kidney Tissue Lysate
Lane 2: Rat Liver Tissue Lysate
Lane 3: 293T Cell Lysate
Lane 4: HELA Cell Lysate

anti-HSD17B1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-HSD17B1 antibody    Anti-HSD17B1 antibody, MBS177074, IHC(P)
IHC(P): Rat Liver Tissue
anti-HSD17B1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-HSD17B1 antibody    Anti-HSD17B1 antibody, MBS177074, IHC(P)
IHC(P): Rat Ovary Tissue
anti-HSD17B1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-HSD17B1 antibody    Anti-HSD17B1 antibody, MBS177074, IHC(P)
IHC(P): Human Placenta Tissue
anti-HSD17B1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HSD17B1. It may not necessarily be applicable to this product.
 NCBI GI #    313104233
 NCBI GeneID    3292
 NCBI Accession #    P14061.3 [Other Products]
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 UniProt Primary Accession #    P14061 [Other Products]
 UniProt Secondary Accession #    Q2M2L8; B3KXS1 [Other Products]
 UniProt Related Accession #    P14061 [Other Products]
 Molecular Weight    34,950 Da
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 NCBI Official Full Name    Estradiol 17-beta-dehydrogenase 1
 NCBI Official Synonym Full Names    hydroxysteroid (17-beta) dehydrogenase 1
 NCBI Official Symbol    HSD17B1 [Similar Products]
 NCBI Official Synonym Symbols   
HSD17; EDHB17; EDH17B2; SDR28C1
[Similar Products]
 NCBI Protein Information    estradiol 17-beta-dehydrogenase 1; E2DH; 20-alpha-HSD; 17-beta-HSD 1; estradiol 17-beta-dehydrogenase-1; 20 alpha-hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase type 1; placental 17-beta-hydroxysteroid dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 1 isoform; short chain dehydrogenase/reductase family 28CE, member 1
 UniProt Protein Name    Estradiol 17-beta-dehydrogenase 1
 UniProt Synonym Protein Names   
17-beta-hydroxysteroid dehydrogenase type 1; 17-beta-HSD 1; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; E2DH; Placental 17-beta-hydroxysteroid dehydrogenase
 Protein Family    Estradiol 17-beta-dehydrogenase
 UniProt Gene Name    HSD17B1 [Similar Products]
 UniProt Synonym Gene Names    E17KSR; EDH17B1; EDH17B2; EDHB17; 17-beta-HSD 1; 20-alpha-HSD [Similar Products]
 UniProt Entry Name    DHB1_HUMAN
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 UniProt Comments for HSD17B1    HSD17B1: Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: Lipid Metabolism - androgen and estrogen; EC 1.1.1.62; Oxidoreductase

Chromosomal Location of Human Ortholog: 17q11-q21

Cellular Component: nucleoplasm; nuclear membrane; cytoplasm; cytosol

Molecular Function: estradiol 17-beta-dehydrogenase activity; catalytic activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity

Biological Process: steroid metabolic process; estrogen metabolic process; steroid biosynthetic process; estrogen biosynthetic process
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 Research Articles on HSD17B1    1. Onset of epileptiform discharges is modestly delayed in slices from ovariectomized rats replaced with physiologically relevant doses of EB, but the number of discharges is not affected.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HSD17B1 antibodyPathways associated with anti-HSD17B1 antibody
 Reference Product  PubMed Publications
 CYP19A1 antibody  >49 publications with HSD17B1 and CYP19A1
 CYP1A1 antibody  >19 publications with HSD17B1 and CYP1A1
 CYP1B1 antibody  >18 publications with HSD17B1 and CYP1B1
 SULT1E1 antibody  >4 publications with HSD17B1 and SULT1E1
 UGT2B15 antibody  >3 publications with HSD17B1 and UGT2B15
 CYP3A4 antibody  >3 publications with HSD17B1 and CYP3A4
 UGT2B17 antibody  >2 publications with HSD17B1 and UGT2B17
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Estrogen Biosynthesis Pathway antibodies  Estrogen Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
Diseases associated with anti-HSD17B1 antibodyOrgans/Tissues associated with anti-HSD17B1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >35 publications with HSD17B1 and Breast Neoplasms
 Endometriosis Antibodies  >16 publications with HSD17B1 and Endometriosis
 Genital Diseases, Male Antibodies  >11 publications with HSD17B1 and Genital Diseases, Male
 Adenocarcinoma Antibodies  >9 publications with HSD17B1 and Adenocarcinoma
 Prostatic Diseases Antibodies  >7 publications with HSD17B1 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >7 publications with HSD17B1 and Prostatic Neoplasms
 Congenital Abnormalities Antibodies  >6 publications with HSD17B1 and Congenital Abnormalities
 Urogenital Abnormalities Antibodies  >5 publications with HSD17B1 and Urogenital Abnormalities
 Disorders of Sex Development Antibodies  >4 publications with HSD17B1 and Disorders of Sex Development
 Ovarian Diseases Antibodies  >4 publications with HSD17B1 and Ovarian Diseases
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >15 publications with HSD17B1 and Placenta
 Brain Antibodies  >7 publications with HSD17B1 and Brain
 Uterus Antibodies  >5 publications with HSD17B1 and Uterus
 Embryonic Tissue Antibodies  >5 publications with HSD17B1 and Embryonic Tissue
 Testis Antibodies  >5 publications with HSD17B1 and Testis
 Mammary Gland Antibodies  >4 publications with HSD17B1 and Mammary Gland
 Stomach Antibodies  >3 publications with HSD17B1 and Stomach
 Bone Antibodies  >2 publications with HSD17B1 and Bone
 Intestine Antibodies  >1 publications with HSD17B1 and Intestine
 Kidney Antibodies  >1 publications with HSD17B1 and Kidney
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