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anti-HSP27 antibody :: Rabbit HSP27 / Heat Shock Protein 27 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242332
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HSP27 / Heat Shock Protein 27, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human HSP27 / Heat Shock Protein 27

 Product Synonym Names    Anti-HSP27 / Heat Shock Protein 27 Antibody IHC-plus; Heat Shock Protein 27; Human HSP27; Heat Shock Protein 27
 Product Gene Name   

anti-HSP27 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 608634
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Monkey
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 Purity/Purification    Protein A Purified
 Form/Format    PBS, 0.09% azide, 50% glycerol
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 Target Species    Human
 Immunogen Description    Recombinant human Hsp27 protein.
 Immunogen Type    Recombinant protein
 Immunogen    Recombinant human Hsp27 protein.
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 Preparation and Storage    Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-HSP27 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HSP27 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-HSP27 antibody    IHC-P (10 ug/ml), IP (10 ug/ml), WB (1:11000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-HSP27 antibody    Anti-HSP27 / Heat Shock Protein 27 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-HSP27 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-HSP27 antibody    Anti-HSP27 / Heat Shock Protein 27 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-HSP27 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HSP27. It may not necessarily be applicable to this product.
 NCBI GI #    11036357
 NCBI GeneID    3315
 NCBI Accession #    BAB17232.1 [Other Products]
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 UniProt Secondary Accession #    Q6FI47; Q96C20; Q96EI7; Q9UC31; Q9UC34; Q9UC35; Q9UC36; B2R4N8 [Other Products]
 UniProt Related Accession #    P04792 [Other Products]
 Molecular Weight    22,783 Da
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 NCBI Official Full Name    HSP27
 NCBI Official Synonym Full Names    heat shock 27kDa protein 1
 NCBI Official Symbol    HSPB1 [Similar Products]
 NCBI Official Synonym Symbols   
CMT2F; HMN2B; HSP27; HSP28; Hsp25; SRP27; HS.76067; HEL-S-102
[Similar Products]
 NCBI Protein Information    heat shock protein beta-1; HSP 27; 28 kDa heat shock protein; heat shock 27 kDa protein; heat shock 27kD protein 1; stress-responsive protein 27; estrogen-regulated 24 kDa protein; epididymis secretory protein Li 102
 UniProt Protein Name    Heat shock protein beta-1
 UniProt Synonym Protein Names   
28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27
 Protein Family    Heat shock protein
 UniProt Gene Name    HSPB1 [Similar Products]
 UniProt Synonym Gene Names    HSP27; HSP28; HspB1; HSP 27; SRP27 [Similar Products]
 UniProt Entry Name    HSPB1_HUMAN
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 NCBI Summary for HSP27    The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008]
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 UniProt Comments for HSP27    HSP27: a small heat shock protein that is regulated both transcriptionally and posttranslationally. Modulates actin polymerization and reorganization. Its expression level increases several-fold in response to stress and is phosphorylated by MAPKAP kinase 2. Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock.

Protein type: Heat shock protein; Chaperone; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: proteasome complex; extracellular space; focal adhesion; cytoskeleton; cytoplasm; plasma membrane; spindle; Z disc; cytosol; nucleus

Molecular Function: identical protein binding; protein kinase C inhibitor activity; ubiquitin binding; protein binding; protein kinase C binding; protein kinase binding

Biological Process: positive regulation of tumor necrosis factor biosynthetic process; response to virus; positive regulation of blood vessel endothelial cell migration; response to unfolded protein; positive regulation of interleukin-1 beta production; retinal homeostasis; positive regulation of angiogenesis; negative regulation of protein kinase activity; gene expression; cell motility; regulation of I-kappaB kinase/NF-kappaB cascade; vascular endothelial growth factor receptor signaling pathway; regulation of translational initiation; negative regulation of apoptosis

Disease: Neuronopathy, Distal Hereditary Motor, Type Iib; Charcot-marie-tooth Disease, Axonal, Type 2f
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 Research Articles on HSP27    1. Hsp27 protein was found to be commonly expressed in cervical epithelial cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HSP27 antibodyDiseases associated with anti-HSP27 antibody
 Products by Pathway  Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >121 publications with HSP27 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >94 publications with HSP27 and Disease Models, Animal
 Necrosis Antibodies  >69 publications with HSP27 and Necrosis
 Inflammation Antibodies  >66 publications with HSP27 and Inflammation
 Breast Neoplasms Antibodies  >61 publications with HSP27 and Breast Neoplasms
 Heart Diseases Antibodies  >60 publications with HSP27 and Heart Diseases
 Liver Diseases Antibodies  >42 publications with HSP27 and Liver Diseases
 Reperfusion Injury Antibodies  >35 publications with HSP27 and Reperfusion Injury
 Kidney Diseases Antibodies  >31 publications with HSP27 and Kidney Diseases
 Lung Neoplasms Antibodies  >30 publications with HSP27 and Lung Neoplasms
Organs/Tissues associated with anti-HSP27 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >229 publications with HSP27 and Muscle
 Blood Antibodies  >155 publications with HSP27 and Blood
 Brain Antibodies  >154 publications with HSP27 and Brain
 Heart Antibodies  >115 publications with HSP27 and Heart
 Nerve Antibodies  >109 publications with HSP27 and Nerve
 Vascular Antibodies  >97 publications with HSP27 and Vascular
 Liver Antibodies  >81 publications with HSP27 and Liver
 Lung Antibodies  >72 publications with HSP27 and Lung
 Kidney Antibodies  >72 publications with HSP27 and Kidney
 Skin Antibodies  >44 publications with HSP27 and Skin
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