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anti-HSPA1A antibody :: Rabbit HSPA1A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2520129
Immunohistochemistry (IHC)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HSPA1A, Polyclonal Antibody

★Popular Item★
 Also Known As   

HSPA1A Polyclonal Antibody

 Product Synonym Names    HSP72, HSPA1, HSP70I, HSP70-1, HSP70-1A
 Product Gene Name   

anti-HSPA1A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    140550
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    1mg/mL (lot specific)
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 Immunogen    Recombinant protein of human HSPA1A
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-HSPA1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HSPA1A antibody

   This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
 Applications Tested/Suitable for anti-HSPA1A antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-HSPA1A antibody    IHC: 1:50-1:100
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 Immunohistochemistry (IHC) of anti-HSPA1A antibody    Immunohistochemistry of paraffin-embedded Human colon cancer tissue using HSPA1A Polyclonal Antibody at dilution 1:40
anti-HSPA1A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HSPA1A. It may not necessarily be applicable to this product.
 NCBI GI #    194248072
 NCBI GeneID    3303
 NCBI Accession #    NP_005336.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005345.5 [Other Products]
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 UniProt Secondary Accession #    P19790; Q5JQI4; Q5SP17; Q9UQL9; Q9UQM0; B4E3B6 [Other Products]
 UniProt Related Accession #    P08107 [Other Products]
 Molecular Weight    63,937 Da
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 NCBI Official Full Name    heat shock 70 kDa protein 1A/1B
 NCBI Official Synonym Full Names    heat shock 70kDa protein 1A
 NCBI Official Symbol    HSPA1A [Similar Products]
 NCBI Official Synonym Symbols   
HSP72; HSPA1; HSP70I; HSP70-1; HSP70-1A; HEL-S-103
[Similar Products]
 NCBI Protein Information    heat shock 70 kDa protein 1A/1B; HSP70-1/HSP70-2; dnaK-type molecular chaperone HSP70-1; epididymis secretory protein Li 103; heat shock 70 kDa protein 1/2; heat shock 70kD protein 1A; heat shock-induced protein
 UniProt Protein Name    Heat shock 70 kDa protein 1A/1B
 UniProt Synonym Protein Names   
Heat shock 70 kDa protein 1/2; HSP70-1/HSP70-2; HSP70.1/HSP70.2
 Protein Family    Heat shock 70 kDa protein
 UniProt Gene Name    HSPA1A [Similar Products]
 UniProt Synonym Gene Names    HSPA1; HSX70; HSP70-1/HSP70-2; HSP70.1/HSP70.2 [Similar Products]
 UniProt Entry Name    HSP71_HUMAN
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 NCBI Summary for HSPA1A    This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HSPA1A    HSP70: a critical chaperone protein that has a high affinity for unfolded polypeptide chains. It binds extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In cooperation with other chaperones, hsp70 stabilizes preexistent proteins against aggregation and mediates the folding of newly translated polypeptides in the cytosol as well as within organelles. Mitochondrial HSP70 is crucial to the import process: mutant forms of HSP70 fail to import precursor proteins. Is anti-apoptotic in sympathetic neurones and mediates this effect primarily by suppressing c-Jun transcriptional signalling. Interacts with tau protein and mediates proper folding of tau. Can promote the degradation of tau protein. Triptolide, a potential therapeutic agent for progression/metastasis of pancreatic cancer, causes pancreatic cancer cell death by induction of apoptosis, an effect mediated by the inhibition of HSP70.

Protein type: Motility/polarity/chemotaxis; Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: signalosome; focal adhesion; mitochondrion; endoplasmic reticulum; inclusion body; cytosol; ribonucleoprotein complex; centriole; nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nuclear speck; nucleus; vesicle; ubiquitin ligase complex

Molecular Function: viral receptor activity; protein binding; enzyme binding; G-protein-coupled receptor binding; heat shock protein binding; ubiquitin protein ligase binding; ATPase activity; double-stranded RNA binding; unfolded protein binding; protein N-terminus binding; ATPase activity, coupled; ATP binding

Biological Process: negative regulation of cell proliferation; entry of virus into host cell; protein stabilization; positive regulation of erythrocyte differentiation; mRNA catabolic process; negative regulation of protein ubiquitination; protein refolding; gene expression; negative regulation of cell growth; response to unfolded protein; negative regulation of apoptosis
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 Research Articles on HSPA1A    1. Given no translocation of cytosolic HSP72, these findings suggest eccentric contractions, unlike other forms of stress such as heat, do not trigger tight binding of HSP72 to its primary membrane-bound target proteins, in particular SERCA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HSPA1A antibodyPathways associated with anti-HSPA1A antibody
 Reference Product  PubMed Publications
 DNAJB1 antibody  >20 publications with HSPA1A and DNAJB1
 HSF1 antibody  >14 publications with HSPA1A and HSF1
 BAG3 antibody  >6 publications with HSPA1A and BAG3
 HSPBP1 antibody  >4 publications with HSPA1A and HSPBP1
 STIP1 antibody  >3 publications with HSPA1A and STIP1
 BAG1 antibody  >3 publications with HSPA1A and BAG1
 TP53 antibody  >2 publications with HSPA1A and TP53
 STUB1 antibody  >1 publications with HSPA1A and STUB1
 Products by Pathway  Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
Diseases associated with anti-HSPA1A antibodyOrgans/Tissues associated with anti-HSPA1A antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >27 publications with HSPA1A and Cardiovascular Diseases
 Inflammation Antibodies  >23 publications with HSPA1A and Inflammation
 Nervous System Diseases Antibodies  >14 publications with HSPA1A and Nervous System Diseases
 Disease Models, Animal Antibodies  >13 publications with HSPA1A and Disease Models, Animal
 Heart Diseases Antibodies  >12 publications with HSPA1A and Heart Diseases
 Necrosis Antibodies  >10 publications with HSPA1A and Necrosis
 Atherosclerosis Antibodies  >9 publications with HSPA1A and Atherosclerosis
 Brain Diseases Antibodies  >9 publications with HSPA1A and Brain Diseases
 Liver Diseases Antibodies  >9 publications with HSPA1A and Liver Diseases
 Lung Diseases Antibodies  >7 publications with HSPA1A and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >44 publications with HSPA1A and Blood
 Brain Antibodies  >21 publications with HSPA1A and Brain
 Liver Antibodies  >19 publications with HSPA1A and Liver
 Kidney Antibodies  >12 publications with HSPA1A and Kidney
 Vascular Antibodies  >12 publications with HSPA1A and Vascular
 Heart Antibodies  >11 publications with HSPA1A and Heart
 Skin Antibodies  >10 publications with HSPA1A and Skin
 Muscle Antibodies  >10 publications with HSPA1A and Muscle
 Nerve Antibodies  >9 publications with HSPA1A and Nerve
 Lung Antibodies  >8 publications with HSPA1A and Lung
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