NP_055121.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,210 Da
NCBI Official Full Name
tRNA-splicing ligase RtcB homolog
NCBI Official Synonym Full Names
RNA 2',3'-cyclic phosphate and 5'-OH ligase
NCBI Official Synonym Symbols
FAAP; HSPC117; C22orf28; DJ149A16.6 [Similar Products]
NCBI Protein Information
tRNA-splicing ligase RtcB homolog
UniProt Protein Name
tRNA-splicing ligase RtcB homolog
UniProt Entry Name
RTCB_HUMAN
UniProt Comments for C22orf28
RTCB: Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs. Belongs to the RtcB family.
Protein type: EC 6.5.1.3
Chromosomal Location of Human Ortholog: 22q12
Cellular Component: cytoplasm; endoplasmic reticulum membrane; nuclear envelope; nucleoplasm; nucleus
Molecular Function: ATP binding; metal ion binding; protein binding; RNA ligase (ATP) activity; vinculin binding
Biological Process: in utero embryonic development; placenta development; tRNA splicing
Research Articles on C22orf28
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Pathways associated with anti-C22orf28 antibody
Diseases associated with anti-C22orf28 antibody
Organs/Tissues associated with anti-C22orf28 antibody
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