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anti-HTR6 antibody :: Rabbit HTR6 / 5-HT6 Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS244405
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HTR6 / 5-HT6 Receptor, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human HTR6 / 5-HT6 Receptor

 Product Synonym Names    Anti-HTR6 / 5-HT6 Receptor Antibody (C-Terminus) IHC-plus; HTR6; 5-HT6; 5-HT6R; 5-HT-6; 5-hydroxytryptamine receptor 6; 5-HT6 receptor; 5-HT6 serotonin receptor; 5-hydroxytryptamine 6 receptor; Serotonin 6 receptor; Serotonin receptor 6; Serotonin 5-HT-6 receptor; Serotonin type 6 receptor; Human HTR6; 5-HT6 Receptor
 Product Gene Name   

anti-HTR6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601109
 3D Structure    ModBase 3D Structure for P50406
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gibbon, Chimpanzee, Dog, Gorilla, Hamster, Horse, Human, Monkey, Rat
Predicted Reactivity: Mouse, Bat, Bovine, Rabbit (at least 90% immunogen sequence identity)
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 Specificity    Human HTR6 / 5-HT36. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    0.7 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 17 amino acid peptide from C-terminus of human HTR6 / 5-HT36. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Rat, Hamster, Panda, Dog, Horse (100%).
 Immunogen Type    Synthetic peptide
 Immunogen    HTR6 / 5-HT6 Receptor antibody was raised against synthetic 17 amino acid peptide from C-terminus of human HTR6 / 5-HT36. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Monkey, Marmoset, Rat, Hamster, Panda, Dog, Horse (100%); Mouse, Elephant, Bovine, Bat, Rabbit (94%); Stickleback, Pufferfish (88%); Turkey, Chicken, Xenopus, Zebrafish (82%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-HTR6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-HTR6 antibody

   5-HT6, a Serotonin Receptor, appears to regulate cholinergic neurotransmission in the brain rather than the expected interaction as a modulator of dopaminergic transmission. This interaction predicts a possible role for 5-HT6 Receptor antagonists in the treatment of learning and memory disorders. The 5-HT6 Receptor is abundant in limbic areas, which participate in the control of mood and emotion.
 Product Categories/Family for anti-HTR6 antibody    Family: GPCR
Subfamily: Serotonin
 Applications Tested/Suitable for anti-HTR6 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-HTR6 antibody    IHC-P (10 - 20 ug/ml)
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 Immunohistochemistry (IHC) of anti-HTR6 antibody    Human, Brain, Cerebellum: Formalin-Fixed Paraffin-Embedded (FFPE)
anti-HTR6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HTR6. It may not necessarily be applicable to this product.
 NCBI GI #    4504545
 NCBI GeneID    3362
 NCBI Accession #    NP_000862.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000871.2 [Other Products]
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 UniProt Primary Accession #    P50406 [Other Products]
 UniProt Secondary Accession #    Q13640; Q5TGZ1 [Other Products]
 UniProt Related Accession #    P50406 [Other Products]
 Molecular Weight    46,954 Da
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 NCBI Official Full Name    5-hydroxytryptamine receptor 6
 NCBI Official Synonym Full Names    5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
 NCBI Official Symbol    HTR6 [Similar Products]
 NCBI Official Synonym Symbols   
5-HT6; 5-HT6R
[Similar Products]
 NCBI Protein Information    5-hydroxytryptamine receptor 6; serotonin receptor 6
 UniProt Protein Name    5-hydroxytryptamine receptor 6
 UniProt Synonym Protein Names   
Serotonin receptor 6
 Protein Family    Transducer protein
 UniProt Gene Name    HTR6 [Similar Products]
 UniProt Synonym Gene Names    5-HT-6; 5-HT6 [Similar Products]
 UniProt Entry Name    5HT6R_HUMAN
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 NCBI Summary for HTR6    This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
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 UniProt Comments for HTR6    5-HT(6): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 1p36-p35

Cellular Component: integral to plasma membrane; dendrite; plasma membrane; cilium

Molecular Function: protein binding; serotonin receptor activity; histamine receptor activity

Biological Process: response to drug; G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of dopamine secretion; synaptic transmission; cerebral cortex cell migration; negative regulation of glutamate secretion; negative regulation of gamma-aminobutyric acid secretion; negative regulation of acetylcholine secretion; learning; serotonin receptor signaling pathway; response to estradiol stimulus; positive regulation of TOR signaling pathway; positive regulation of gamma-aminobutyric acid secretion
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 Research Articles on HTR6    1. Studies indicate that serotonin 5-HT6 receptor (5-HT6R) has been proposed as a promising drug target for cognition enhancement in Alzheimer's disease (AD).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HTR6 antibodyPathways associated with anti-HTR6 antibody
 Reference Product  PubMed Publications
 HTR7 antibody  >8 publications with HTR6 and HTR7
 HTR4 antibody  >6 publications with HTR6 and HTR4
 DRD5 antibody  >1 publications with HTR6 and DRD5
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
Diseases associated with anti-HTR6 antibodyOrgans/Tissues associated with anti-HTR6 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >16 publications with HTR6 and Mental Disorders
 Schizophrenia Antibodies  >6 publications with HTR6 and Schizophrenia
 Nervous System Diseases Antibodies  >5 publications with HTR6 and Nervous System Diseases
 Poisoning Antibodies  >2 publications with HTR6 and Poisoning
 Movement Disorders Antibodies  >1 publications with HTR6 and Movement Disorders
 Hallucinations Antibodies  >1 publications with HTR6 and Hallucinations
 Cognition Disorders Antibodies  >1 publications with HTR6 and Cognition Disorders
 Dyskinesia, Drug-Induced Antibodies  >1 publications with HTR6 and Dyskinesia, Drug-Induced
 Seizures Antibodies  >1 publications with HTR6 and Seizures
 Amphetamine-Related Disorders Antibodies  >1 publications with HTR6 and Amphetamine-Related Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with HTR6 and Brain
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