Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow HTT rightarrow Polyclonal HTT  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Dihydropyrimidinase-related protein 2 (DPYSL2) Recombinant Protein
 • MPA ELISA Kit
 • PPAR Delta Antibody
 • Thyroxine, T4 ELISA Kit
 • 10 kDa chaperonin (groS) Recombinant Protein
 • Biotin Conjugated Mouse Anti-rabbit IgG Secondary Antibody
 • Immunodominant staphylococcal antigen B (isaB) Recombinant Protein
 • S100B Recombinant Protein
 • Carbonic Anhydrase IX (CA9) Antibody
 • 17-Beta-Hydroxysteroid Dehydrogenase Type 3 (HSD17b3) Recombinant Protein
 • Dermato-Pontin (DPT) ELISA Kit
 • Thrombospondin-2 (THBS2) ELISA Kit
 • ASK1 (MAP3K5) Blocking Peptide
 • AAC-rich mRNA clone AAC4 protein (AAC4) (DDB_G0267458) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetView Full DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-HTT antibody :: Rabbit anti-Human HTT / Huntingtin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240583
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HTT / Huntingtin, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Human HTT / Huntingtin

 Product Synonym Names    Anti-HTT / Huntingtin Antibody (phospho-Ser421) IHC-plus; HTT; Huntingtin; Huntington disease protein; IT15; HD; HD protein; Human HTT; Huntingtin
 Product Gene Name   

anti-HTT antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    phenotype 613004
 3D Structure    ModBase 3D Structure for P42858
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
Section Bar
 Specificity    Amino acids 416 to 424 of Human huntingtin protein phosphorylated at Ser421
 Purity/Purification    Immunoaffinity Purified
 Form/Format    0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
 Concentration    1 mg/ml (lot specific)
Section Bar
 Target Species    Human
 Immunogen Description    Synthetic peptide from human HTT / Huntingtin.
 Immunogen Type    Synthetic peptide
 Immunogen    HTT / Huntingtin antibody was raised against synthetic peptide from human HTT / Huntingtin.
 Antigen Modification    pSer421
Section Bar
 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-HTT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-HTT antibody

   Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological.
 Product Categories/Family for anti-HTT antibody    Family: Hungtintin
Section Bar
 Applications Tested/Suitable for anti-HTT antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-HTT antibody    ELISA (1:10000 - 1:40000), IHC-P (10 - 20 ug/ml), WB (1:500 - 1:3000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo...
Section Bar
 Immunohistochemistry (IHC) of anti-HTT antibody    Anti-HTT / Huntingtin antibody IHC of human brain cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
anti-HTT antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Western Blot (WB) of anti-HTT antibody    Anti-Huntingtin pS421 Antibody - Western Blot. Western blot analysis after AKT and phosphatase treatment is shown using Affinity Purified anti-Huntingtin pS421 antibody. In A) untreated lysates from N2A and 293A cells were stained directly using anti-Huntingtin pS421 antibody. Full length staining of Huntingtin is noted, albeit at low levels of expression, as well as a strongly staining band at 200 kD that may represent staining of truncated protein. In B) staining is shown after immunoprecipitation using a monoclonal antibody (Mab2166) followed by AKT treatment (to phosphorylate), along with untreated, and phosphatase (PP) treated (dephosphorylate) immunoprecipitated. Full length phosphorylated huntingtin is clearly detected in these immunopurified samples (except dephosphorylated). In C) lysates are treated directly with AKT or PP to alter the phosphorylation status of Htt. Personal communication, Simon Warby, CMMT, Vancouver, BC.
anti-HTT antibody Western Blot (WB) (WB) image
Section Bar
 Western Blot (WB) of anti-HTT antibody    Anti-Huntingtin pS421 Antibody - Western Blot. Western blot analysis is shown using Affinity Purified anti-Huntingtin pS421 antibody to detect endogenous protein present in an unstimulated human PC-3 whole cell lysate (arrowhead). Comparison to a molecular weight marker indicates a band of ~190 kD corresponding to truncated human Huntingtin protein. The blot was incubated with a 1:1000 dilution of the antibody at room temperature followed by detection using standard techniques. Personal communication,.
anti-HTT antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for HTT. It may not necessarily be applicable to this product.
 NCBI GI #    90903231
 NCBI GeneID    3064
 NCBI Accession #    NP_002102.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_002111.7 [Other Products]
Section Bar
 UniProt Primary Accession #    P42858 [Other Products]
 UniProt Secondary Accession #    Q9UQB7 [Other Products]
 UniProt Related Accession #    P42858 [Other Products]
 Molecular Weight    347,603 Da
Table BarTOPTable Bar
 NCBI Official Full Name    huntingtin
 NCBI Official Synonym Full Names    huntingtin
 NCBI Official Symbol    HTT [Similar Products]
 NCBI Official Synonym Symbols   
HD; IT15
[Similar Products]
 NCBI Protein Information    huntingtin; huntington disease protein
 UniProt Protein Name    Huntingtin
 UniProt Synonym Protein Names   
Huntington disease protein; HD protein
 Protein Family    HD protein
 UniProt Gene Name    HTT [Similar Products]
 UniProt Synonym Gene Names    HD; IT15; HD protein [Similar Products]
 UniProt Entry Name    HD_HUMAN
Section Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-HTT antibodyPathways associated with anti-HTT antibody
 Reference Product  PubMed Publications
 HAP1 antibody  >35 publications with HTT and HAP1
 HIP1 antibody  >24 publications with HTT and HIP1
 UBC antibody  >13 publications with HTT and UBC
 CREBBP antibody  >11 publications with HTT and CREBBP
 ZDHHC17 antibody  >8 publications with HTT and ZDHHC17
 GAPDH antibody  >6 publications with HTT and GAPDH
 SH3GL3 antibody  >4 publications with HTT and SH3GL3
 OPTN antibody  >4 publications with HTT and OPTN
 PACSIN1 antibody  >4 publications with HTT and PACSIN1
 PRPF40A antibody  >1 publications with HTT and PRPF40A
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
Diseases associated with anti-HTT antibodyOrgans/Tissues associated with anti-HTT antibody
 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >1541 publications with HTT and Neurodegenerative Diseases
 Huntington Disease Antibodies  >1528 publications with HTT and Huntington Disease
 Brain Diseases Antibodies  >1501 publications with HTT and Brain Diseases
 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Antibodies  >1425 publications with HTT and Congenital, Hereditary, and Neonatal Diseases and Abnormalities
 Cognition Disorders Antibodies  >1405 publications with HTT and Cognition Disorders
 Movement Disorders Antibodies  >1405 publications with HTT and Movement Disorders
 Nerve Degeneration Antibodies  >181 publications with HTT and Nerve Degeneration
 Anxiety Disorders Antibodies  >175 publications with HTT and Anxiety Disorders
 Atrophy Antibodies  >118 publications with HTT and Atrophy
 Cardiovascular Diseases Antibodies  >56 publications with HTT and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1393 publications with HTT and Brain
 Blood Antibodies  >324 publications with HTT and Blood
 Muscle Antibodies  >84 publications with HTT and Muscle
 Embryonic Tissue Antibodies  >80 publications with HTT and Embryonic Tissue
 Vascular Antibodies  >56 publications with HTT and Vascular
 Liver Antibodies  >41 publications with HTT and Liver
 Eye Antibodies  >40 publications with HTT and Eye
 Lung Antibodies  >34 publications with HTT and Lung
 Thyroid Antibodies  >33 publications with HTT and Thyroid
 Kidney Antibodies  >32 publications with HTT and Kidney
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions